Familial dementia caused by polymerization of mutant neuroserpin

Nature ◽  
10.1038/43894 ◽  
1999 ◽  
Vol 401 (6751) ◽  
pp. 376-379 ◽  
Author(s):  
Richard L. Davis ◽  
Antony E. Shrimpton ◽  
Peter D. Holohan ◽  
Charles Bradshaw ◽  
David Feiglin ◽  
...  
Keyword(s):  
Familial Dementia

Role of tau in non-familial dementia

2000 ◽  
Vol 21 ◽  
pp. 285
Author(s):  
Kirk C. Wilhelmsen ◽  
Daniel Geschwind ◽  
Lorraine N. Clark ◽  
Maria J. Sobrido ◽  
Sietske N. Heyn ◽  
...  
Keyword(s):  
Familial Dementia

scholarly journals The complex relationship between genotype, pathology and phenotype in familial dementia

2020 ◽  
Vol 145 ◽  
pp. 105082
Author(s):  
John B. Kwok ◽  
Clement T. Loy ◽  
Carol Dobson-Stone ◽  
Glenda M. Halliday
Keyword(s):  
Complex Relationship ◽  
Familial Dementia

scholarly journals Familial dementia due to a frameshift mutation in the caeruloplasmin gene

QJM ◽  
1996 ◽  
Vol 89 (5) ◽  
pp. 355-360 ◽  
Author(s):  
Z.L. Harris ◽  
M.C. Migas ◽  
A.E. Hughes ◽  
J.I. Logan ◽  
J.D. Gitlin
Keyword(s):  
Frameshift Mutation ◽  
Familial Dementia

scholarly journals Immunological Associations in Familial and Non-Familial Alzheimer Patients and Their Families

1994 ◽  
Vol 21 (2) ◽  
pp. 112-119 ◽  
Author(s):  
M.F. Frecker ◽  
W.E.M. Pryse-Philli ◽  
H.R. Strong
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Alzheimer Disease ◽  
Autoimmune Diseases ◽  
Alzheimer Type ◽  
The Family ◽  
Sporadic Disease ◽  
Hla Dr3 ◽  
Adult Exposure ◽  
Familial Dementia

Abstract:A number of autoimmune diseases and immune-related conditions were investigated in a series of 100 Alzheimer patients and their families. The group was divided into those who had familial dementia of the Alzheimer type and non-familial dementia of the Alzheimer type. HLA DR3 was associated with the familial dementia of the Alzheimer type patients. Adult exposure to tuberculosis appeared to be a risk factor for familial dementia of the Alzheimer type patients. Autoimmune diseases clustered among the non-familial dementia of the Alzheimer type patients, and also among their relatives. Asthma and infertility were also significantly increased among non-familial dementia of the Alzheimer type relatives. The analysis showed that (1) autoimmunity may be important in the sporadic form of Alzheimer disease; (2) it may be possible to confer a decreased risk for Alzheimer disease among relatives when many autoimmune diseases occur in the family; (3) it may be important to assess environmental risk factors for Alzheimer disease separately in patients with familial and sporadic disease; and (4) the efficacy of drug therapies may be dependent on whether the patients have a familial or sporadic form of Alzheimer disease.

Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia

2005 ◽  
Vol 332 (3) ◽  
pp. 808-816 ◽  
Author(s):  
Laura Morelli ◽  
Ramiro E. Llovera ◽  
Leonardo G. Alonso ◽  
Blas Frangione ◽  
Gonzalo de Prat-Gay ◽  
...  
Keyword(s):  
Insulin Degrading Enzyme ◽  
Amyloid Peptides ◽  
Degrading Enzyme ◽  
Familial Dementia

IMMUNOLOCALIZATION OF HEPARAN SULFATE PROTEOSLYCANS TO ???PRIMITIVE PLAQUES??? AND MULTI-CORE PRION POSITIVE PLAQUES IN FAMILIAL DEMENTIA

1988 ◽  
Vol 2 (3) ◽  
pp. 232 ◽  
Author(s):  
ALAN D. SNOW ◽  
DAVID NOCHLIN ◽  
S. M. SUMI ◽  
THOMAS D. BIRD ◽  
THOMAS N. WIGHT
Keyword(s):  
Heparan Sulfate ◽  
Familial Dementia

scholarly journals The Familial Dementia BRI2 Gene Binds the Alzheimer Gene Amyloid-β Precursor Protein and Inhibits Amyloid-β Production

2005 ◽  
Vol 280 (32) ◽  
pp. 28912-28916 ◽  
Author(s):  
Shuji Matsuda ◽  
Luca Giliberto ◽  
Yukiko Matsuda ◽  
Peter Davies ◽  
Eileen McGowan ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Precursor Protein ◽  
Familial Dementia

Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type

1987 ◽  
Vol 4 (1) ◽  
pp. 97-108 ◽  
Author(s):  
Gerard D. Schellenberg ◽  
Samir S. Deeb ◽  
Michael Boehnke ◽  
Eileen M. Bryant ◽  
George M. Martin ◽  
...  
Keyword(s):  
Alzheimer Type ◽  
Familial Dementia

Abstract 074: Familial Dementia Versus Healthy Lifestyle On The Risk Of Dementia

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Angelique Brellenthin ◽  
Duck-chul Lee ◽  
Elizabeth Lefferts ◽  
Bong kil Song ◽  
Youngwon Kim
Keyword(s):  
Fruits And Vegetables ◽  
Cox Regression ◽  
Healthy Lifestyle ◽  
Vigorous Physical Activity ◽  
Joint Analysis ◽  
Hospital Inpatient ◽  
Degree Relative ◽  
Healthy Behaviors ◽  
The Uk ◽  
Familial Dementia

Introduction: Familial dementia (FD) is one of the strongest risk factors for dementia. Little is known about the independent and combined associations of having FD and following a healthy lifestyle with the risk of dementia. Hypothesis: We hypothesized that FD and a healthy lifestyle would be independently associated with the risk of dementia and that a healthy lifestyle would attenuate the risk of dementia among those with FD. Methods: Participants were 302,239 men and women aged 60±5 years who completed a baseline examination between 2006-2010 as part of the UK Biobank study. Participants with dementia at baseline were excluded. FD was defined as dementia in a first-degree relative (i.e., mother, father, or siblings). For healthy behaviors, participants were given one point for each of the following: not having obesity (body mass index <30 kg/m 2 ); ≥150 min/wk of moderate-to-vigorous physical activity; sleep duration between 6-9 hr; drinking in moderation (>0 to ≤14 or 7 drinks/wk for men or women, respectively); not smoking; and following a healthy diet (e.g., more fruits and vegetables; less processed meats and refined grains). Participants were categorized on whether they had ≤2 (reference), 3, 4, 5, or 6 healthy behaviors. Cox regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) of incident dementia (according to hospital inpatient records and death registry) by FD and number of healthy behaviors. In a joint analysis, participants were categorized based on reporting FD and following ≥3 behaviors. Models were adjusted for age, sex, race, education, socioeconomic status (Townsend deprivation index), hypertension, hypercholesterolemia, diabetes, and depression, with mutual adjustment for healthy behaviors and FD. Results: During an average follow-up of 8 years, 1698 (0.6%) participants developed dementia. Compared to ≤2 healthy behaviors, the HRs (95% CI) were 0.70 (0.57-0.86), 0.58 (0.48-0.70), 0.58 (0.48-0.70) and 0.49 (0.39-0.60) for 3, 4, 5, or 6 behaviors, respectively, after adjusting for the confounders including FD. Compared to no FD, HR (95% CI) of dementia was 1.72 (1.53-1.93) among those with FD after adjusting for the confounders including healthy behaviors. In the joint analysis, compared to those with “FD and ≤2 healthy behaviors”, the HRs (95% CI) for dementia were 0.65 (0.42-0.99), 0.74 (0.47-1.15), and 0.37 (0.25-0.56) for those with “FD and ≥3 behaviors”, “no FD and ≤2 behaviors”, and “no FD and ≥3 behaviors”, respectively. Conclusions: Adopting more healthy behaviors was associated with reduced risk of dementia, independent of FD. In those with FD, adopting at least 3 healthy behaviors may help reduce the risk of developing dementia.

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