Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells

Nature ◽  
10.1038/40166 ◽  
1997 ◽  
Vol 389 (6654) ◽  
pp. 978-981 ◽  
Author(s):  
Robert C. Fuhlbrigge ◽  
J. David Kieffer ◽  
Dieter Armerding ◽  
Thomas S. Kupper
Keyword(s):  
T Cells ◽  
Lymphocyte Antigen ◽  
Skin Homing ◽  
Specialized Form ◽  
Cutaneous Lymphocyte Antigen

Neutrophils, Monocytes, and Dendritic Cells Express the Same Specialized Form of PSGL-1 as Do Skin-Homing Memory T Cells: Cutaneous Lymphocyte Antigen

2001 ◽  
Vol 285 (3) ◽  
pp. 577-587 ◽  
Author(s):  
J.David Kieffer ◽  
Robert C. Fuhlbrigge ◽  
Dieter Armerding ◽  
Caroline Robert ◽  
Katalin Ferenczi ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Memory T Cells ◽  
Lymphocyte Antigen ◽  
Skin Homing ◽  
Specialized Form ◽  
Cutaneous Lymphocyte Antigen

IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis

2006 ◽  
Vol 117 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Janine Bilsborough ◽  
Donald Y.M. Leung ◽  
Mark Maurer ◽  
Michael Howell ◽  
Mark Boguniewcz ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Positive Skin ◽  
Lymphocyte Antigen ◽  
Skin Homing ◽  
Cutaneous Lymphocyte Antigen

scholarly journals Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

1994 ◽  
Vol 127 (5) ◽  
pp. 1485-1495 ◽  
Author(s):  
R Alon ◽  
H Rossiter ◽  
X Wang ◽  
T A Springer ◽  
T S Kupper
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
Cell Surface ◽  
Antigen Expression ◽  
Lymphocyte Antigen ◽  
Selectin Ligands ◽  
Distinct Cell ◽  
Cutaneous Lymphocyte Antigen

Memory T lymphocytes extravasate at sites of inflammation, but the mechanisms employed by these cells to initiate contact and tethering with endothelium are incompletely understood. An important part of leukocyte extravasation is the initiation of rolling adhesions on endothelial selectins; such events have been studied in monocytes and neutrophils but not lymphocytes. In this study, the potential of T lymphocytes to adhere and roll on endothelial selectins in vitro was investigated. We demonstrate that T cells can form tethers and rolling adhesions on P selectin and E selectin under physiologic flow conditions. Tethering and rolling on P selectin was independent of cell-surface cutaneous lymphocyte antigen (CLA) expression, which correlated strictly with the capacity of T cells to form rolling adhesions under flow on E selectin. T cell tethering to P selectin was abolished by selective removal of cell surface sialomucins by a P. haemolytica O-glycoprotease, while cutaneous lymphocyte antigen expression was unaffected. A sialomucin molecule identical or closely related to P selectin glycoprotein ligand-1 (PSGL-1), the major P selectin ligand on neutrophils and HL-60 cells, appears to be a major T cell ligand for P selectin. P selectin glycoprotein ligand-1 does not appear to support T cell rolling on E selectin. In turn, E selectin ligands do not appear to be associated with sialomucins. These data demonstrate the presence of structurally distinct ligands for P or E selectins on T cells, provide evidence that both ligands can be coexpressed on a single T cell, and mediate tethering and rolling on the respective selectins in a mutually exclusive fashion.

Milk-induced urticaria is associated with the expansion of T cells expressing cutaneous lymphocyte antigen

2002 ◽  
Vol 109 (4) ◽  
pp. 688-693 ◽  
Author(s):  
Kirsten Beyer ◽  
Russell Castro ◽  
Carolyn Feidel ◽  
Hugh A. Sampson
Keyword(s):  
T Cells ◽  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen

scholarly journals The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1.

1991 ◽  
Vol 174 (6) ◽  
pp. 1461-1466 ◽  
Author(s):  
E L Berg ◽  
T Yoshino ◽  
L S Rott ◽  
M K Robinson ◽  
R A Warnock ◽  
...  
Keyword(s):  
T Cells ◽  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Leukocyte Adhesion ◽  
Lymphocyte Homing ◽  
Neuraminidase Treatment ◽  
Leukocyte Adhesion Molecule ◽  
Homing Receptor ◽  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen

A skin-associated population of memory T lymphocytes, defined by expression of the cutaneous lymphocyte antigen (CLA), binds selectively and avidly to the vascular lectin endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), an interaction that may be involved in targeting of CLA+ T cells to cutaneous sites of chronic inflammation. Here we present evidence that CLA itself is the (or a) lymphocyte homing receptor for ELAM-1. Antigen isolated with anti-CLA monoclonal antibody HECA-452 from human tonsillar lysates avidly binds ELAM-1 transfected mouse cells. Anti-CLA antibody blocks T lymphocyte binding to ELAM-1 transfectants. HECA-452 and ELAM-1 binding to lymphocytes or to isolated tonsillar HECA-452 antigen is abrogated by neuraminidase treatment implying a prominent role for sialic acid in CLA structure and function. The dominant form of CLA on T cells is immunologically distinct from the major neutrophil ELAM-1 ligand, the sialyl Lewis x (sLex) antigen (NeuAc alpha 2-3Gal beta 1-4[Fuc alpha 1-3]GlcNAc), which is absent, weakly expressed, or masked on T cells. However, neuraminidase treatment of CLA+ T cells, but not of CLA- T cells, reveals Lewis x (CD15) structures. In combination with the known requirement for terminal NeuAc alpha 2-3Gal and fucose residues attached to N-acetylglucosamine for ELAM-1 and HECA-452 binding, this finding suggests that CLA may comprise an additionally sialylated or otherwise modified form of sLex. The identification of a lymphocyte homing receptor for skin may permit novel approaches to the diagnosis and therapy of cutaneous and inflammatory disorders.

scholarly journals Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen.

1995 ◽  
Vol 95 (2) ◽  
pp. 913-918 ◽  
Author(s):  
K J Abernathy-Carver ◽  
H A Sampson ◽  
L J Picker ◽  
D Y Leung
Keyword(s):  
T Cells ◽  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen
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