scholarly journals Animal mitochondrial DNA recombination

Nature ◽  
1997 ◽  
Vol 387 (6630) ◽  
pp. 247-247 ◽  
Author(s):  
David H. Lunt ◽  
Bradley C. Hyman
Keyword(s):  
Mitochondrial Dna ◽  
Dna Recombination ◽  
Mitochondrial Dna Recombination

Animal mitochondrial DNA recombination revisited

2003 ◽  
Vol 18 (8) ◽  
pp. 411-417 ◽  
Author(s):  
Antonis Rokas ◽  
Emmanuel Ladoukakis ◽  
Eleftherios Zouros
Keyword(s):  
Mitochondrial Dna ◽  
Dna Recombination ◽  
Mitochondrial Dna Recombination

Mitochondria and the success of somatic cell nuclear transfer cloning: from nuclear - mitochondrial interactions to mitochondrial complementation and mitochondrial DNA recombination

2005 ◽  
Vol 17 (2) ◽  
pp. 69 ◽  
Author(s):  
Stefan Hiendleder ◽  
Valeri Zakhartchenko ◽  
Eckhard Wolf
Keyword(s):  
Mitochondrial Dna ◽  
Somatic Cell ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Dna Recombination ◽  
Epigenetic Reprogramming ◽  
Research Activities ◽  
Mitochondrial Functions ◽  
New Findings ◽  
Mitochondrial Dna Recombination

The overall success of somatic cell nuclear transfer (SCNT) cloning is rather unsatisfactory, both in terms of efficacy and from an animal health and welfare point of view. Most research activities have concentrated on epigenetic reprogramming problems as one major cause of SCNT failure. The present review addresses the limited success of mammalian SCNT from yet another viewpoint, the mitochondrial perspective. Mitochondria have a broad range of critical functions in cellular energy supply, cell signalling and programmed cell death and, thus, affect embryonic and fetal development, suggesting that inadequate or perturbed mitochondrial functions may adversely affect SCNT success. A survey of perinatal clinical data from human subjects with deficient mitochondrial respiratory chain activity has revealed a plethora of phenotypes that have striking similarities with abnormalities commonly encountered in SCNT fetuses and offspring. We discuss the limited experimental data on nuclear–mitochondrial interaction effects in SCNT and explore the potential effects in the context of new findings about the biology of mitochondria. These include mitochondrial fusion/fission, mitochondrial complementation and mitochondrial DNA recombination, processes that are likely to be affected by and impact on SCNT cloning. Furthermore, we indicate pathways that could link epigenetic reprogramming and mitochondria effects in SCNT and address questions and perspectives for future research.

scholarly journals Heterologous mitochondrial DNA recombination in human cells

2004 ◽  
Vol 13 (24) ◽  
pp. 3171-3179 ◽  
Author(s):  
Marilena D'Aurelio ◽  
Carl D. Gajewski ◽  
Michael T. Lin ◽  
William M. Mauck ◽  
Leon Z. Shao ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Recombination ◽  
Human Cells ◽  
Mitochondrial Dna Recombination

scholarly journals Mitochondrial DNA recombination in a free-ranging Australian lizard

2007 ◽  
Vol 3 (2) ◽  
pp. 189-192 ◽  
Author(s):  
Beata Ujvari ◽  
Mark Dowton ◽  
Thomas Madsen
Keyword(s):  
Mitochondrial Dna ◽  
Dna Recombination ◽  
Hybrid Zones ◽  
Mitochondrial Recombination ◽  
Widespread Occurrence ◽  
Mitochondrial Haplotypes ◽  
Frequent Use ◽  
Molecular Machinery ◽  
Mitochondrial Dna Recombination ◽  
Free Ranging

Mitochondrial DNA (mtDNA) is the traditional workhorse for reconstructing evolutionary events. The frequent use of mtDNA in such analyses derives from the apparent simplicity of its inheritance: maternal and lacking bi-parental recombination. However, in hybrid zones, the reproductive barriers are often not completely developed, resulting in the breakdown of male mitochondrial elimination mechanisms, leading to leakage of paternal mitochondria and transient heteroplasmy, resulting in an increased possibility of recombination. Despite the widespread occurrence of heteroplasmy and the presence of the molecular machinery necessary for recombination, we know of no documented example of recombination of mtDNA in any terrestrial wild vertebrate population. By sequencing the entire mitochondrial genome (16 761 bp), we present evidence for mitochondrial recombination in the hybrid zone of two mitochondrial haplotypes in the Australian frillneck lizard ( Chlamydosaurus kingii ).

scholarly journals A Genome-Wide Map of Mitochondrial DNA Recombination in Yeast

Genetics ◽  
2014 ◽  
Vol 198 (2) ◽  
pp. 755-771 ◽  
Author(s):  
Emilie S. Fritsch ◽  
Christophe D. Chabbert ◽  
Bernd Klaus ◽  
Lars M. Steinmetz
Keyword(s):  
Mitochondrial Dna ◽  
Dna Recombination ◽  
Genome Wide ◽  
A Genome ◽  
Mitochondrial Dna Recombination

scholarly journals A Properly Configured Ring Structure Is Critical for the Function of the Mitochondrial DNA Recombination Protein, Mgm101

2012 ◽  
Vol 287 (44) ◽  
pp. 37259-37268 ◽  
Author(s):  
Jonathan D. Nardozzi ◽  
Xiaowen Wang ◽  
MacMillan Mbantenkhu ◽  
Stephan Wilkens ◽  
Xin Jie Chen
Keyword(s):  
Mitochondrial Dna ◽  
Dna Recombination ◽  
Ring Structure ◽  
Recombination Protein ◽  
Mitochondrial Dna Recombination

Mitochondrial DNA recombination in Brassica campestris

Plant Science ◽  
2009 ◽  
Vol 177 (6) ◽  
pp. 629-635 ◽  
Author(s):  
Medha Manchekar ◽  
Karyn D. Scissum-Gunn ◽  
Lisa A. Hammett ◽  
Steffen Backert ◽  
Brent L. Nielsen
Keyword(s):  
Mitochondrial Dna ◽  
Brassica Campestris ◽  
Dna Recombination ◽  
Mitochondrial Dna Recombination
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