scholarly journals Erratum: wingless refines its own expression domain on the Drosophila wing margin

Nature ◽  
1996 ◽  
Vol 384 (6609) ◽  
pp. 597-597
Author(s):  
Eric J. Rulifson ◽  
Craig A. Micchelli ◽  
Jeffrey D. Axelrod ◽  
Norbert Perrimon ◽  
Seth S. Blair
Keyword(s):  
Wing Margin ◽  
Expression Domain ◽  
Drosophila Wing

wingless refines its own expression domain on the Drosophila wing margin

Nature ◽  
1996 ◽  
Vol 384 (6604) ◽  
pp. 72-74 ◽  
Author(s):  
Eric J. Rulifson ◽  
Craig A. Micchelli ◽  
Jeffrey D. Axelrod ◽  
Norbert Perrimon ◽  
Seth S. Blair
Keyword(s):  
Wing Margin ◽  
Expression Domain ◽  
Drosophila Wing

scholarly journals Effect of wing scalloping mutations on cut expression and sense organ differentiation in the Drosophila wing margin.

Genetics ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 353-363 ◽  
Author(s):  
J Jack ◽  
Y DeLotto
Keyword(s):  
Sense Organ ◽  
Epidermal Cells ◽  
Additive Effect ◽  
Mutant Phenotype ◽  
Wing Margin ◽  
Transcriptional Enhancer ◽  
Organ Differentiation ◽  
Notch Activity ◽  
Neural Fate ◽  
Drosophila Wing

Abstract A number of wing scalloping mutations have been examined to determine their effects on the mutant phenotype of cut mutations and on the expression of the Cut protein. The mutations fall into two broad classes, those which interact synergistically with weak cut wing mutations to produce a more extreme wing phenotype than either mutation alone and those that have a simple additive effect with weak cut wing mutations. The synergistically interacting mutations are alleles of the Notch, Serrate and scalloped genes. These mutations affect development of the wing margin in a manner similar to the cut wing mutations. The mutations inactivate the cut transcriptional enhancer for the wing margin mechanoreceptors and noninnervated bristles and prevent differentiation of the organs. Surprisingly, reduction of Notch activity in the wing margin does not have the effect of converting epidermal cells to a neural fate as it does in other tissues of ectodermal origin. Rather, it prevents the differentiation of the wing margin mechanoreceptors and noninnervated bristles.

scholarly journals SNARE-Dependent Signaling at the Drosophila Wing Margin

2001 ◽  
Vol 234 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Bryan A. Stewart ◽  
Mahmood Mohtashami ◽  
Lily Zhou ◽  
William S. Trimble ◽  
Gabrielle L. Boulianne
Keyword(s):  
Wing Margin ◽  
Drosophila Wing

scholarly journals Identification of Genetic Loci That Interact WithcutDuring Drosophila Wing-Margin Development

Genetics ◽  
2005 ◽  
Vol 170 (4) ◽  
pp. 1775-1795 ◽  
Author(s):  
Joshua J. Krupp ◽  
Lauren E. Yaich ◽  
Robert J. Wessells ◽  
Rolf Bodmer
Keyword(s):  
Wing Margin ◽  
Genetic Loci ◽  
Drosophila Wing

scholarly journals A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles

2016 ◽  
Vol 36 (44) ◽  
pp. 11275-11282 ◽  
Author(s):  
Jiefu Li ◽  
Wei Zhang ◽  
Zhenhao Guo ◽  
Sophia Wu ◽  
Lily Yeh Jan ◽  
...  
Keyword(s):  
Mechanical Stimuli ◽  
Wing Margin ◽  
Drosophila Wing

Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc

Development ◽  
1997 ◽  
Vol 124 (15) ◽  
pp. 2973-2981 ◽  
Author(s):  
R.J. Fleming ◽  
Y. Gu ◽  
N.A. Hukriede
Keyword(s):  
Imaginal Disc ◽  
Ectopic Expression ◽  
Wing Disc ◽  
Specific Response ◽  
Wing Margin ◽  
Drosophila Wing ◽  
Imaginal Wing Disc ◽  
Dorsoventral Boundary ◽  
Drosophila Cells ◽  
Notch Ligands

In the developing imaginal wing disc of Drosophila, cells at the dorsoventral boundary require localized Notch activity for specification of the wing margin. The Notch ligands Serrate and Delta are required on opposite sides of the presumptive wing margin and, even though activated forms of Notch generate responses on both sides of the dorsoventral boundary, each ligand generates a compartment-specific response. In this report we demonstrate that Serrate, which is expressed in the dorsal compartment, does not signal in the dorsal regions due to the action of the fringe gene product. Using ectopic expression, we show that regulation of Serrate by fringe occurs at the level of protein and not Serrate transcription. Furthermore, replacement of the N-terminal region of Serrate with the corresponding region of Delta abolishes the ability of fringe to regulate Serrate without altering Serrate-specific signaling.

scholarly journals Arf6 is necessary for senseless expression in response to Wingless signalling during Drosophila wing development

Biology Open ◽  
2021 ◽  
Author(s):  
Julien Marcetteau ◽  
Tamàs Matusek ◽  
Frédéric Luton ◽  
Pascal P. Thérond
Keyword(s):  
Signal Transduction ◽  
Developmental Model ◽  
Wing Development ◽  
Wing Margin ◽  
Drosophila Wing ◽  
Gtp Binding ◽  
Wide Range ◽  
High Level

Wnt signalling is a core pathway involved in a wide range of developmental processes throughout the metazoa. In vitro studies have suggested that the small GTP binding protein Arf6 regulates upstream steps of Wnt transduction, by promoting the phosphorylation of the Wnt co-receptor, LRP6, and the release of β-catenin from the adherens junctions. To assess the relevance of these previous findings in vivo, we analysed the consequence of the absence of Arf6 activity on Drosophila wing patterning, a developmental model of Wnt/Wingless signalling. We observed a dominant loss of wing margin bristles and Senseless expression in Arf6 mutant flies, phenotypes characteristic of a defect in high level Wingless signalling. In contrast to previous findings, we show that Arf6 is required downstream of Armadillo/β-catenin stabilisation in Wingless signal transduction. Our data suggest that Arf6 modulates the activity of a downstream nuclear regulator of Pangolin activity in order to control the induction of high level Wingless signalling. Our findings represent a novel regulatory role for Arf6 in Wingless signalling.

scholarly journals The Ecdysone receptor constrains wingless expression to pattern cell cycle across the Drosophila wing margin in a cyclin B-dependent manner

2013 ◽  
Vol 13 (1) ◽  
pp. 28 ◽  
Author(s):  
Naomi C Mitchell ◽  
Jane I Lin ◽  
Olga Zaytseva ◽  
Nicola Cranna ◽  
Amanda Lee ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cyclin B ◽  
Dependent Manner ◽  
Wing Margin ◽  
Ecdysone Receptor ◽  
Drosophila Wing
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