Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

Nature ◽  
1995 ◽  
Vol 375 (6534) ◽  
pp. 761-766 ◽  
Author(s):  
Ajay Chitnis ◽  
Domingos Henrique ◽  
Julian Lewis ◽  
David Ish-Horowicz ◽  
Chris Kintner
Keyword(s):  
Xenopus Embryos ◽  
Primary Neurogenesis

The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis

Development ◽  
1997 ◽  
Vol 124 (3) ◽  
pp. 693-702 ◽  
Author(s):  
D.A. Wettstein ◽  
D.L. Turner ◽  
C. Kintner
Keyword(s):  
Dna Binding ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Cell Interaction ◽  
Notch Signaling Pathway ◽  
Notch 1 ◽  
Xenopus Embryos ◽  
Suppressor Of Hairless ◽  
Primary Neurogenesis ◽  
Enhancer Of Split

The X-Notch-1 receptor, and its putative ligand, X-Delta-1, are thought to mediate an inhibitory cell-cell interaction, called lateral inhibition, that limits the number of primary neurons that form in Xenopus embryos. The expression of Xenopus ESR-1, a gene related to Drosophila Enhancer of split, appears to be induced by Notch signaling during this process. To determine how the activation of X-Notch-1 induces ESR-1 expression and regulates primary neurogenesis, we isolated the Xenopus homolog of Suppressor of Hairless (X-Su(H)), a component of the Notch signaling pathway in Drosophila. Using animal cap assays, we show that X-Su(H) induces ESR-1 expression, perhaps directly, when modified by the addition of ankyrin repeats. Using a DNA binding mutant of X-Su(H), we show that X-Su(H) activity is required for induction of ESR-1. Finally, expression of the DNA binding mutant in embryos leads to a neurogenic phenotype as well as increased expression of both X-Delta-1 and XNGNR1, a proneural gene expressed during primary neurogenesis. These results suggest that activation of X-Su(H) is a key step in the Notch signaling pathway during primary neurogenesis in Xenopus embryos.

Deep Cytoplasmic Rearrangements in Axis-Respecified Xenopus Embryos

1993 ◽  
Vol 160 (1) ◽  
pp. 157-164 ◽  
Author(s):  
J.M. Denegre ◽  
M.V. Danilchik
Keyword(s):  
Xenopus Embryos

scholarly journals 4-Methylcyclohexane methanol (MCHM) affects viability, development, and movement of Xenopus embryos

2021 ◽  
Vol 8 ◽  
pp. 38-43
Author(s):  
Mark Perfetto ◽  
Scotia G. Kirkham ◽  
Michael C. Ayers ◽  
Shuo Wei ◽  
Jennifer E.G. Gallagher
Keyword(s):  
Xenopus Embryos

scholarly journals xSyndecan-1 and dorsal–ventral patterning of Xenopus embryos

2007 ◽  
Vol 306 (1) ◽  
pp. 409
Author(s):  
Gonzalo H. Olivares ◽  
Hector Carrasco ◽  
Francisco Aroca ◽  
Juan Larrain
Keyword(s):  
Xenopus Embryos

scholarly journals Frizzled-10 promotes sensory neuron development in Xenopus embryos

2009 ◽  
Vol 335 (1) ◽  
pp. 143-155 ◽  
Author(s):  
Carla Garcia-Morales ◽  
Chiung-Hui Liu ◽  
Muhammad Abu-Elmagd ◽  
Mohammad K. Hajihosseini ◽  
Grant N. Wheeler
Keyword(s):  
Sensory Neuron ◽  
Neuron Development ◽  
Xenopus Embryos
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