scholarly journals Ice-binding structure and mechanism of an antifreeze protein from winter flounder

Nature ◽  
1995 ◽  
Vol 375 (6530) ◽  
pp. 427-431 ◽  
Author(s):  
F. Sicheri ◽  
D. S. C. Yang
Keyword(s):  
Antifreeze Protein ◽  
Winter Flounder ◽  
Ice Binding ◽  
Binding Structure

Why ice-binding type I antifreeze protein acts as a gas hydrate crystal inhibitor

2015 ◽  
Vol 17 (15) ◽  
pp. 9984-9990 ◽  
Author(s):  
S. Alireza Bagherzadeh ◽  
Saman Alavi ◽  
John A. Ripmeester ◽  
Peter Englezos
Keyword(s):  
Gas Hydrate ◽  
Antifreeze Protein ◽  
Winter Flounder ◽  
Methyl Groups ◽  
Type I ◽  
Cooperative Action ◽  
Ice Binding ◽  
Hydrate Crystal ◽  
Binding Type

The winter flounder antifreeze protein (wf-AFP) acts as a gas hydrate crystal inhibitor by binding to the empty-half cages at the hydrate surfaceviathe cooperative action between methyl groups of threonine and alanine residues.

Induction of Winter Flounder Antifreeze Protein Messenger RNA at 4 C in vivo and in vitro

1986 ◽  
Vol 59 (6) ◽  
pp. 679-695 ◽  
Author(s):  
Jeffrey L. Price ◽  
Brian B. Gourlie ◽  
Yuan Lin ◽  
Ru Chih C. Huang
Keyword(s):  
Messenger Rna ◽  
Antifreeze Protein ◽  
Winter Flounder

Structures and ice-binding faces of the alanine-rich type I antifreeze proteinsThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

2010 ◽  
Vol 88 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Shruti N. Patel ◽  
Steffen P. Graether
Keyword(s):  
Analytical Ultracentrifugation ◽  
Peer Review Process ◽  
Winter Flounder ◽  
Type I ◽  
Ice Binding ◽  
Shorthorn Sculpin ◽  
High Resolution Structure ◽  
Dimerization Interface ◽  
Α Helix ◽  
Almost All

Antifreeze proteins (AFPs) protect cold-blooded organisms from the damage caused by freezing through their ability to inhibit ice growth. The type I AFP family, found in several fish species, contains proteins that have a high alanine content (>60% of the sequence) and structures that are almost all α-helical. We examine the structure of the type I AFP isoforms HPLC6 from winter flounder, shorthorn sculpin 3, and the winter flounder hyperactive type I AFP. The HPLC6 isoform structure consists of a single α-helix that is 37 residues long, whereas the shorthorn sculpin 3 isoform consists of two helical regions separated by a kink. The high-resolution structure of the hyperactive type I AFP has yet to be determined, but circular dichroism data and analytical ultracentrifugation suggest that the 195 residue protein is a side-by-side dimer of two α-helices. The alanine-rich ice-binding faces of HPLC6 and hyperactive type I AFP are discussed, and we propose that the ice-binding face of the shorthorn sculpin 3 AFP contains Ala14, Ala19, and Ala25. We also propose that the denaturation of hyperactive type I AFP at room temperature is explained by the stabilization of the dimerization interface through hydrogen bonds.

Winter Flounder Antifreeze Protein Improves the Cold Hardiness of Plant Tissues

1989 ◽  
Vol 135 (3) ◽  
pp. 351-354 ◽  
Author(s):  
Adrian J. Cutler ◽  
M. Saleem ◽  
Edward Kendall ◽  
Lawrence V. Gusta ◽  
F. Georges ◽  
...  
Keyword(s):  
Cold Hardiness ◽  
Antifreeze Protein ◽  
Winter Flounder ◽  
Plant Tissues

Investigation of the Ice-Binding Site of an Insect Antifreeze Protein Using Sum-Frequency Generation Spectroscopy

2015 ◽  
Vol 6 (7) ◽  
pp. 1162-1167 ◽  
Author(s):  
Konrad Meister ◽  
Stephan Lotze ◽  
Luuk L. C. Olijve ◽  
Arthur L. DeVries ◽  
John G. Duman ◽  
...  
Keyword(s):  
Binding Site ◽  
Antifreeze Protein ◽  
Sum Frequency Generation ◽  
Sum Frequency ◽  
Sum Frequency Generation Spectroscopy ◽  
Ice Binding ◽  
Frequency Generation

Antifreeze Protein from Freeze-Tolerant Grass Has a Beta-Roll Fold with an Irregularly Structured Ice-Binding Site

2012 ◽  
Vol 416 (5) ◽  
pp. 713-724 ◽  
Author(s):  
Adam J. Middleton ◽  
Christopher B. Marshall ◽  
Frédérick Faucher ◽  
Maya Bar-Dolev ◽  
Ido Braslavsky ◽  
...  
Keyword(s):  
Binding Site ◽  
Antifreeze Protein ◽  
Ice Binding ◽  
Freeze Tolerant
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