Neural progenitor cell engraftment corrects lysosomal storage throughout the MRS VII mouse brain

Nature ◽  
1995 ◽  
Vol 374 (6520) ◽  
pp. 367-370 ◽  
Author(s):  
Evan Y. Snyder ◽  
Rosanne M. Taylor ◽  
John H. Wolfe
Keyword(s):  
Mouse Brain ◽  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Lysosomal Storage ◽  
Cell Engraftment

scholarly journals Human Neural Progenitor Cell Engraftment Increases Neurogenesis and Microglial Recruitment in the Brain of Rats with Stroke

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50444 ◽  
Author(s):  
Zahra Hassani ◽  
Joanna O'Reilly ◽  
Yewande Pearse ◽  
Paul Stroemer ◽  
Ellen Tang ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Cell Engraftment ◽  
Human Neural Progenitor Cell ◽  
The Brain

MRI visualization of endogenous neural progenitor cell migration along the RMS in the adult mouse brain: Validation of various MPIO labeling strategies

NeuroImage ◽  
2010 ◽  
Vol 49 (3) ◽  
pp. 2094-2103 ◽  
Author(s):  
Ruth Vreys ◽  
Greetje Vande Velde ◽  
Olga Krylychkina ◽  
Michiel Vellema ◽  
Marleen Verhoye ◽  
...  
Keyword(s):  
Cell Migration ◽  
Mouse Brain ◽  
Progenitor Cell ◽  
Adult Mouse ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Adult Mouse Brain ◽  
Labeling Strategies

scholarly journals Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development

2008 ◽  
Vol 106 (2) ◽  
pp. 718-733 ◽  
Author(s):  
Guanghu Wang ◽  
Kannan Krishnamurthy ◽  
Ying-Wei Chiang ◽  
Somsankar Dasgupta ◽  
Erhard Bieberich
Keyword(s):  
Brain Development ◽  
Cell Motility ◽  
Mouse Brain ◽  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Mouse Brain Development

scholarly journals Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin

2017 ◽  
Vol 216 (7) ◽  
pp. 1975-1992 ◽  
Author(s):  
Yanxin Li ◽  
Jianwei Jiao
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Progenitor Cell ◽  
Neural Progenitor Cells ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Histone Chaperone ◽  
Epigenetic Mechanism ◽  
Progenitor Cell Proliferation ◽  
Early Neurogenesis

Histone cell cycle regulator (HIRA) is a histone chaperone and has been identified as an epigenetic regulator. Subsequent studies have provided evidence that HIRA plays key roles in embryonic development, but its function during early neurogenesis remains unknown. Here, we demonstrate that HIRA is enriched in neural progenitor cells, and HIRA knockdown reduces neural progenitor cell proliferation, increases terminal mitosis and cell cycle exit, and ultimately results in premature neuronal differentiation. Additionally, we demonstrate that HIRA enhances β-catenin expression by recruiting H3K4 trimethyltransferase Setd1A, which increases H3K4me3 levels and heightens the promoter activity of β-catenin. Significantly, overexpression of HIRA, HIRA N-terminal domain, or β-catenin can override neurogenesis abnormities caused by HIRA defects. Collectively, these data implicate that HIRA, cooperating with Setd1A, modulates β-catenin expression and then regulates neurogenesis. This finding represents a novel epigenetic mechanism underlying the histone code and has profound and lasting implications for diseases and neurobiology.

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