Crystal structure of the tyrosine kinase domain of the human insulin receptor

Nature ◽  
1994 ◽  
Vol 372 (6508) ◽  
pp. 746-754 ◽  
Author(s):  
Stevan R. Hubbard ◽  
Lei Wei ◽  
Wayne A. Hendrickson
Keyword(s):  
Crystal Structure ◽  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Human Insulin Receptor

N.m.r. structural studies on the tyrosine kinase domain of the human insulin receptor

1989 ◽  
Vol 17 (5) ◽  
pp. 899-899
Author(s):  
ROBERT A. ATKINSON ◽  
WAYNE J. FAIRBROTHER ◽  
BARRY A. LEVINE ◽  
JEREMY TAVARÈ ◽  
BEA CLACK ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Structural Studies ◽  
Human Insulin Receptor

scholarly journals Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.

1986 ◽  
Vol 6 (8) ◽  
pp. 3000-3004 ◽  
Author(s):  
H Matsushime ◽  
L H Wang ◽  
M Shibuya
Keyword(s):  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Transmembrane Domain ◽  
Human Gene ◽  
Kinase Domain ◽  
Glycosylation Site ◽  
Tyrosine Kinase Domain ◽  
Base Pairs ◽  
Human Insulin Receptor ◽  
Sarcoma Virus

We isolated a human gene (designated c-ros-1) homologous to the v-ros sequence of UR2 sarcoma virus. Ten exons, 1,414 base pairs spanning 26 kilobases, contained a tyrosine kinase domain, a transmembrane domain, and a part of an extracellular domain carrying an N glycosylation site which was not acquired by UR2 sarcoma virus. The predicted structure of c-ros-1 is unique among the src family and clearly distinct from the human insulin receptor.

Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule

1986 ◽  
Vol 6 (8) ◽  
pp. 3000-3004
Author(s):  
H Matsushime ◽  
L H Wang ◽  
M Shibuya
Keyword(s):  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Transmembrane Domain ◽  
Human Gene ◽  
Kinase Domain ◽  
Glycosylation Site ◽  
Tyrosine Kinase Domain ◽  
Base Pairs ◽  
Human Insulin Receptor ◽  
Sarcoma Virus

We isolated a human gene (designated c-ros-1) homologous to the v-ros sequence of UR2 sarcoma virus. Ten exons, 1,414 base pairs spanning 26 kilobases, contained a tyrosine kinase domain, a transmembrane domain, and a part of an extracellular domain carrying an N glycosylation site which was not acquired by UR2 sarcoma virus. The predicted structure of c-ros-1 is unique among the src family and clearly distinct from the human insulin receptor.

NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene

Diabetes ◽  
1992 ◽  
Vol 41 (4) ◽  
pp. 521-526 ◽  
Author(s):  
S. Cocozza ◽  
A. Porcellini ◽  
G. Riccardi ◽  
A. Monticelli ◽  
G. Condorelli ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Receptor Gene ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Insulin Receptor Gene

Hyperinsulinemia but No Diabetes in Transgenic Mice Homozygously Expressing the Tyrosine Kinase-Deficient Human Insulin Receptor

1997 ◽  
Vol 240 (2) ◽  
pp. 446-451 ◽  
Author(s):  
Lihong Wang ◽  
Naoko Muromoto ◽  
Hideki Hayashi ◽  
Yasumasa Mitani ◽  
Hisanori Uehara ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Human Insulin Receptor
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