Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

Nature ◽  
1994 ◽  
Vol 372 (6505) ◽  
pp. 432-438 ◽  
Author(s):  
Chris Oubridge ◽  
Nobutoshi Ito ◽  
Philip R. Evans ◽  
C.-Hiang Teo ◽  
Kiyoshi Nagai
Keyword(s):  
Crystal Structure ◽  
Rna Binding ◽  
Binding Domain ◽  
Spliceosomal Protein ◽  
Rna Binding Domain ◽  
Rna Hairpin

Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein

1997 ◽  
Vol 4 (11) ◽  
pp. 896-899 ◽  
Author(s):  
Jinsong Liu ◽  
Patricia A. Lynch ◽  
Chen-ya Chien ◽  
Gaetano T. Montelione ◽  
Robert M. Krug ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Influenza Virus ◽  
Rna Binding ◽  
Binding Domain ◽  
Ns1 Protein ◽  
Rna Binding Domain

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

Nature ◽  
1990 ◽  
Vol 348 (6301) ◽  
pp. 515-520 ◽  
Author(s):  
Kiyoshi Nagai ◽  
Chris Oubridge ◽  
Timm H. Jessen ◽  
Jade Li ◽  
Philip R. Evans
Keyword(s):  
Crystal Structure ◽  
Rna Binding ◽  
Binding Domain ◽  
Small Nuclear Ribonucleoprotein ◽  
Rna Binding Domain ◽  
Nuclear Ribonucleoprotein

scholarly journals Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

2020 ◽  
Author(s):  
Sisi Kang ◽  
Mei Yang ◽  
Zhongsi Hong ◽  
Liping Zhang ◽  
Zhaoxia Huang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Nucleocapsid Protein ◽  
Rna Binding ◽  
Structural Information ◽  
Antiviral Drug ◽  
Binding Domain ◽  
Binding Studies ◽  
Terminal Domain ◽  
Rna Binding Domain

AbstractThe outbreak of coronavirus disease (COVID-19) in China caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. It is currently no specific viral protein targeted therapeutics yet. Viral nucleocapsid protein is a potential antiviral drug target, serving multiple critical functions during the viral life cycle. However, the structural information of SARS-CoV-2 nucleocapsid protein is yet to be clear. Herein, we have determined the 2.7 Å crystal structure of the N-terminal RNA binding domain of SARS-CoV-2 nucleocapsid protein. Although overall structure is similar with other reported coronavirus nucleocapsid protein N-terminal domain, the surface electrostatic potential characteristics between them are distinct. Further comparison with mild virus type HCoV-OC43 equivalent domain demonstrates a unique potential RNA binding pocket alongside the β-sheet core. Complemented by in vitro binding studies, our data provide several atomic resolution features of SARS-CoV-2 nucleocapsid protein N-terminal domain, guiding the design of novel antiviral agents specific targeting to SARS-CoV-2.

Crystal structure of the RNA-binding domain from transcription termination factor rho

1998 ◽  
Vol 5 (5) ◽  
pp. 352-356 ◽  
Author(s):  
Timothy J. Allison ◽  
Todd C. Wood ◽  
Deborah M. Briercheck ◽  
Fraydoon Rastinejad ◽  
John P. Richardson ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Rna Binding ◽  
Transcription Termination ◽  
Binding Domain ◽  
Termination Factor ◽  
Transcription Termination Factor ◽  
Rna Binding Domain

scholarly journals Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

2020 ◽  
Vol 10 (7) ◽  
pp. 1228-1238 ◽  
Author(s):  
Sisi Kang ◽  
Mei Yang ◽  
Zhongsi Hong ◽  
Liping Zhang ◽  
Zhaoxia Huang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Nucleocapsid Protein ◽  
Drug Targeting ◽  
Rna Binding ◽  
Binding Domain ◽  
Rna Binding Domain
Sign in / Sign up

Export Citation Format

Share Document