Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

Nature ◽  
1994 ◽  
Vol 371 (6499) ◽  
pp. 674-680 ◽  
Author(s):  
Barbara Ensoli ◽  
Rita Gendelman ◽  
Phillip Markham ◽  
Valeria Fiorelli ◽  
Sandra Colombini ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Fibroblast Growth ◽  
Tat Protein ◽  
Hiv 1

scholarly journals Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Cecilia Sgadari ◽  
Giovanni Barillari ◽  
Clelia Palladino ◽  
Stefania Bellino ◽  
Brunella Taddeo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Vascular Tumor ◽  
Fibroblast Growth ◽  
Tat Protein ◽  
Immunodeficiency Virus ◽  
Hiv 1

Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV-) 1-infected individuals. Our previous work indicated that the angiogenic fibroblast growth factor (FGF)-2 and the Tat protein of HIV-1, both expressed in KS lesions of HIV-infected patients, synergize at inducing angioproliferative, KS-like lesions in mice. Here we show that the development of angioproliferative lesions promoted in mice by combined Tat and FGF-2 associates with an increase in the levels of expression of the antiapoptotic Bcl-2 protein. Upregulation of Bcl-2 expression by combined FGF-2 and Tat occurs alsoin vitro, and this protects human primary endothelial cells from programmed cell death. As Bcl-2 is expressed in human KS lesions in a fashion paralleling the progression of the disease, these findings suggest a molecular mechanism by which Tat and FGF-2 cooperate in KS maintenance and progression in HIV-infected individuals.

Fibroblast growth factor 6 gene expression in AIDS-associated Kaposi's sarcoma

The Lancet ◽  
1992 ◽  
Vol 339 (8801) ◽  
pp. 1110-1111 ◽  
Author(s):  
Yao Qi Huang ◽  
Jian Jpun Li ◽  
Alexander Nicolaides ◽  
WeiGuo Zhang ◽  
AlvinE Freidman-Kien
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Fibroblast Growth

scholarly journals The HIV-1 TAT Protein Induces the Expression and Extracellular Appearance of Acidic Fibroblast Growth Factor

1995 ◽  
Vol 270 (29) ◽  
pp. 17457-17467 ◽  
Author(s):  
Susan R. Opalenik ◽  
Jordan T. Shin ◽  
John N. Wehby ◽  
Vinit K. Mahesh ◽  
John A. Thompson
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Tat Protein ◽  
Acidic Fibroblast Growth Factor ◽  
Hiv 1
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