Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment

Nature ◽  
1994 ◽  
Vol 369 (6476) ◽  
pp. 160-163 ◽  
Author(s):  
Thilo Stehle ◽  
Youwei Yan ◽  
Thomas L. Benjamin ◽  
Stephen C. Harrison
1992 ◽  
Vol 40 (2) ◽  
pp. 121
Author(s):  
A Cauvin ◽  
M Svoboda ◽  
J Christophe

2004 ◽  
Vol 279 (40) ◽  
pp. 41573-41579 ◽  
Author(s):  
Michaela Cavaldesi ◽  
Maddalena Caruso ◽  
Olga Sthandier ◽  
Paolo Amati ◽  
Marie Isabelle Garcia

2019 ◽  
Vol 38 (5) ◽  
pp. 1467-1478 ◽  
Author(s):  
Tristan Richard ◽  
Eva Petit ◽  
Laurent Pouységu ◽  
Jean-Pierre Monti ◽  
Arnaud Bondon ◽  
...  

1996 ◽  
Vol 271 (1) ◽  
pp. R101-R108 ◽  
Author(s):  
S. Takahashi ◽  
L. Kapas ◽  
J. Fang ◽  
J. M. Seyer ◽  
Y. Wang ◽  
...  

Interleukin-1 (IL-1) is hypothesized to be involved in physiological sleep regulation and in sleep responses occurring during infectious disease. If this hypothesis is correct, then inhibition of endogenous IL-1 should reduce both normal sleep and N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP)-induced sleep. MDP is a somnogenic substance derived from bacterial cell walls. We report here the effects of a synthetic IL-1 receptor fragment corresponding to amino acid residues 86-95 of the human type I IL-1 receptor (IL-1RF) on spontaneous sleep and IL-1 beta- and MDP-induced sleep and fever in rabbits. Two doses of the IL-1RF (25 and 50 micrograms) were injected into normal rabbits intracerebroventricularly (icv). Both doses significantly decreased spontaneous non-rapid eye movement sleep (NREMS) across a 22-h recording period. Pretreatment of rabbits with 25 micrograms of IL-1RF blocked the somnogenic actions of 10 ng icv IL-1. Similarly, central pretreatment of animals with 25 micrograms IL-1RF significantly attenuated the NREMS-promoting and REMS-suppressive actions of 150 pmol MDP injected centrally. The increase in NREMS and decrease in REMS induced by systemic injection of 12.5 micrograms/kg MDP were also significantly suppressed by central administration of 50 micrograms IL-1RF. In contrast, the febrile response induced by either intracerebroventricularly or intravenously injected MDP were not significantly affected by IL-1RF. These results support the hypothesis that endogenous, brain-derived IL-1 contributes to the maintenance of normal sleep and may mediate sleep responses to systemic as well as central bacterial infections.


FEBS Letters ◽  
2003 ◽  
Vol 555 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Alicia E Smith ◽  
Hauke Lilie ◽  
Ari Helenius

1994 ◽  
Vol 10 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Giorgio Fassina ◽  
Antonio Verdoliva ◽  
Giovanni Cassani ◽  
Marialuisa Melli

1992 ◽  
Vol 41 (3-8) ◽  
pp. 273-282 ◽  
Author(s):  
E.B. Thompson ◽  
L.V. Nazareth ◽  
R. Thulasi ◽  
J. Ashraf ◽  
D. Harbour ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document