Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Martine Clozel; Volker Breu; Kaspar Burri; Jean-Marie Cassal; Walter Fischli; Gillian A. Gray; Georges Hirth; Bernd-Michael Löffier; Marcel Müller; Werner Neidhart; Henri Ramuz

doi:10.1038/365759a0

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Nature ◽

10.1038/365759a0 ◽

1993 ◽

Vol 365 (6448) ◽

pp. 759-761 ◽

Cited By ~ 390

Author(s):

Martine Clozel ◽

Volker Breu ◽

Kaspar Burri ◽

Jean-Marie Cassal ◽

Walter Fischli ◽

...

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pathophysiological Role ◽

Orally Active

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Faculty Opinions recommendation of Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.8282963.8711064 ◽

2011 ◽

Author(s):

David Welsh

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Tissue Targeting ◽

Orally Active

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Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: A role of hyperphosphorylation of PKCε

European Journal of Pharmacology ◽

10.1016/j.ejphar.2008.06.080 ◽

2008 ◽

Vol 591 (1-3) ◽

pp. 211-218 ◽

Cited By ~ 16

Author(s):

Na Li ◽

Nan Jia ◽

De-Zai Dai ◽

Yin Dai

Keyword(s):

Vitamin E ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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The Discovery ofN-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm3009103 ◽

2012 ◽

Vol 55 (17) ◽

pp. 7849-7861 ◽

Cited By ~ 89

Author(s):

Martin H. Bolli ◽

Christoph Boss ◽

Christoph Binkert ◽

Stephan Buchmann ◽

Daniel Bur ◽

...

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Orally Active

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Chronic Effects of a Novel, Orally Active Endothelin Receptor Antagonist, T-0201, in Dogs with Congestive Heart Failure

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199800001-00066 ◽

1998 ◽

Vol 31 ◽

pp. S236-S238 ◽

Cited By ~ 9

Author(s):

Masato Ohnishi ◽

Atsuyuki Wada ◽

Takayoshi Tsutamoto ◽

Daisuke Fukai ◽

Masahide Sawaki ◽

...

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Chronic Effects ◽

Orally Active

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Pharmacological Characterization of PABSA, an Orally Active and Highly Potent Endothelin-Receptor Antagonist

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199907000-00022 ◽

1999 ◽

Vol 34 (1) ◽

pp. 139-147 ◽

Cited By ~ 8

Author(s):

Takanori Iwasaki ◽

Shin-ichi Mihara ◽

Toshitake Shimamura ◽

Masaru Kawakami ◽

Yoko Hayasaki-Kajiwara ◽

...

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Pharmacological Characterization ◽

Orally Active

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Role of endothelin receptor antagonist in preventing small artery hypertrophy induced by exogenous administration of noradrenaline

Journal of Hypertension ◽

10.1097/00004872-199917060-00043 ◽

1999 ◽

Vol 17 (6) ◽

pp. 859-860

Author(s):

H H. Dao ◽

F M.A.C. Martens ◽

A Zaor ◽

J de Champlain ◽

P Moreau

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Small Artery

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Role of Endogenous Endothelin in the Extension of Myocardial Infarct Size Studied with the Endothelin Receptor Antagonist, TAK-044

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199526003-00109 ◽

1995 ◽

Vol 26 ◽

pp. S365-368 ◽

Cited By ~ 18

Author(s):

Masatoyo Kojima ◽

Keiji Kusumoto ◽

Shuji Fujiwara ◽

Toshifumi Watanabe ◽

Masahiko Fujino

Keyword(s):

Infarct Size ◽

Receptor Antagonist ◽

Myocardial Infarct ◽

Endothelin Receptor Antagonist ◽

Myocardial Infarct Size ◽

Endothelin Receptor

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ROLE OF ENDOTHELIN RECEPTOR ANTAGONIST IN PULMONARY HYPERTENSION ASSOCIATED WITH DIET PILLS AND/OR STIMULANTS

CHEST Journal ◽

10.1378/chest.130.4_meetingabstracts.256s-a ◽

2006 ◽

Vol 130 (4) ◽

pp. 256S

Author(s):

Uma M. Mohanasundaram ◽

Roham Zamanian ◽

Ramona Doyle

Keyword(s):

Pulmonary Hypertension ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Diet Pills

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Role of Endothelin in the Circulatory Changes Associated with Small Bowel Strangulation Obstruction in Pigs: Effects of the Endothelin Receptor Antagonist Bosentan

Journal of Surgical Research ◽

10.1006/jsre.2000.6066 ◽

2001 ◽

Vol 96 (2) ◽

pp. 224-232 ◽

Cited By ~ 5

Author(s):

J. Fevang ◽

K. Øvrebø ◽

O. Myking ◽

K. Grong ◽

K. Svanes

Keyword(s):

Small Bowel ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Small Bowel Strangulation ◽

Bowel Strangulation

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Defining the role of endothelins in renal pathophysiology on the basis of selective and unselective endothelin receptor antagonist studies

Current Opinion in Nephrology & Hypertension ◽

10.1097/00041552-199507000-00011 ◽

1995 ◽

Vol 4 (4) ◽

pp. 349-353 ◽

Cited By ~ 19

Author(s):

Ariela Benigni

Keyword(s):

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor

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