Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

Nature ◽  
1993 ◽  
Vol 364 (6439) ◽  
pp. 723-725 ◽  
Author(s):  
Patriclo T. Huerta ◽  
John E. Lisman
Keyword(s):  
Synaptic Plasticity ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1

scholarly journals Syntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shan Shi ◽  
Ke Ma ◽  
Na-Ryum Bin ◽  
Hidekiyo Harada ◽  
Xiaoyu Xie ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1 ◽  
Syntaxin 3

scholarly journals Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Sang Hun Lee ◽  
Vadim Y. Bolshakov ◽  
Jie Shen
Keyword(s):  
Synaptic Plasticity ◽  
Calcium Homeostasis ◽  
Hippocampal Slices ◽  
Field Potential ◽  
Long Term Potentiation ◽  
Ca1 Neurons ◽  
Paired Pulse ◽  
Inhibitory Neurotransmission ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1

AbstractMutations in the Presenilin genes are the major genetic cause of Alzheimer's disease (AD). Presenilin (PS) is highly expressed in the hippocampus, which is particularly vulnerable in AD. Previous studies of PS function in the hippocampus, however, focused exclusively on excitatory neurons. Whether PS regulates inhibitory neuronal function remained unknown. In the current study, we investigate PS function in GABAergic neurons by performing whole-cell and field-potential electrophysiological recordings using acute hippocampal slices from inhibitory neuron-specific PS conditional double knockout (IN-PS cDKO) mice at 2 months of age, before the onset of age-dependent loss of interneurons. We found that the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) is reduced in hippocampal CA1 neurons of IN-PS cDKO mice, whereas the amplitude of sIPSCs is normal. Moreover, the efficacy of inhibitory neurotransmission as assessed with synaptic input/output relations for evoked mono- and di-synaptic IPSCs is markedly lowered in hippocampal CA1 neurons of IN-PS cDKO mice. Consistent with these findings, IN-PS cDKO mice display enhanced paired-pulse facilitation, frequency facilitation and long-term potentiation in the Schaffer collateral-CA1 pathway. Interestingly, depletion of intracellular Ca2+ stores by inhibition of sarcoendoplasmic reticulum Ca2+ ATPase results in a reduction of IPSC amplitude in control hippocampal neurons but not in IN-PS cDKO neurons, suggesting that impaired intracellular calcium homeostasis in the absence of PS may contribute to the deficiencies in inhibitory neurotransmission. Furthermore, the amplitude of IPSCs induced by short trains of presynaptic stimulation and paired-pulse ratio are decreased in IN-PS cDKO mice. These findings show that inactivation of PS in interneurons results in decreased GABAergic responses and enhanced synaptic plasticity in the hippocampus, providing additional evidence for the importance of PS in the regulation of synaptic plasticity and calcium homeostasis.

scholarly journals Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons

Cell Reports ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2955-2966 ◽  
Author(s):  
Na-Ryum Bin ◽  
Ke Ma ◽  
Hidekiyo Harada ◽  
Chi-Wei Tien ◽  
Fiona Bergin ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Crucial Role ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1 ◽  
Syntaxin 4

Changes in [Ca2+]i during adenosine triphosphate-induced synaptic plasticity in hippocampal CA1 neurons of the guinea pig

2002 ◽  
Vol 324 (1) ◽  
pp. 65-68 ◽  
Author(s):  
Yoshihiko Yamazaki ◽  
Satoshi Fujii ◽  
Takeshi Nakamura ◽  
Hiroyoshi Miyakawa ◽  
Yoshihisa Kudo ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Guinea Pig ◽  
Adenosine Triphosphate ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1

scholarly journals Synaptic plasticity in hippocampal CA1 neurons and learning behavior in transient ischemia-loaded gerbils

2013 ◽  
Vol 34 (2) ◽  
pp. 75-85 ◽  
Author(s):  
Jianmin LI ◽  
Hiroshi SASAKI ◽  
Hiroki FUJIWARA ◽  
Hiroshi KATO ◽  
Kenya KANEKO ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Learning Behavior ◽  
Transient Ischemia ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1
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