Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction

Nature ◽  
1993 ◽  
Vol 363 (6424) ◽  
pp. 76-79 ◽  
Author(s):  
Bai Lu ◽  
Wen-mei Fu ◽  
Paul Greengard ◽  
Mu-ming Poo
Keyword(s):  
Neuromuscular Junction ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Synaptic Responses

Actions of calcitonin gene-related peptide in guinea pig gallbladder ganglia

1996 ◽  
Vol 271 (5) ◽  
pp. G876-G883 ◽  
Author(s):  
A. P. Gokin ◽  
L. J. Jennings ◽  
G. M. Mawe
Keyword(s):  
Reversal Potential ◽  
Input Resistance ◽  
Calcitonin Gene Related Peptide ◽  
Reflex Response ◽  
Bathing Solution ◽  
Axon Reflex ◽  
Related Peptide ◽  
Bath Application ◽  
Calcitonin Gene ◽  
Synaptic Responses

The actions of calcitonin gene-related peptide (CGRP) have been determined from intracellular recordings obtained from gallbladder neurons in intact whole mount preparations. In most cells, pressure microejection of CGRP elicited a slow, monophasic depolarization, 4 mV in amplitude, that was associated with a decrease in input resistance and increased excitability. The CGRP-induced depolarization was attenuated in a low-Na+ solution and had a reversal potential of -8 mV. In 10% of the cells, microejection of CGRP elicited a biphasic response that was composed of a rapid transient depolarization followed by a slow depolarization that was similar to the monophasic response. Addition of CGRP (1–10 nM) to the bathing solution elicited a monophasic depolarization and desensitized the cells to applications of CGRP by microejection. Forskolin, applied either by microejection or bath application, also depolarized gallbladder neurons and produced cross-desensitization to CGRP. Responses to substance P were not enhanced by CGRP, and CGRP did not affect fast synaptic responses. It is concluded that CGRP may contribute to a local axon reflex response in gallbladder ganglia.

Distribution of calcitonin gene-related peptide at the neuromuscular junction ofmdxmice

2004 ◽  
Vol 279A (2) ◽  
pp. 798-803 ◽  
Author(s):  
Maria Julia Marques ◽  
Elaine Minatel ◽  
Alessandra Oliveira Guimarães ◽  
Humberto Santo Neto
Keyword(s):  
Neuromuscular Junction ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene
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