Programmed cell death, mitochondria and the plant hypersensitive response

Nature ◽  
2001 ◽  
Vol 411 (6839) ◽  
pp. 848-853 ◽  
Author(s):  
Eric Lam ◽  
Naohiro Kato ◽  
Michael Lawton
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Hypersensitive Response

Pathogen-induced programmed cell death in tobacco

1997 ◽  
Vol 110 (11) ◽  
pp. 1333-1344 ◽  
Author(s):  
R. Mittler ◽  
L. Simon ◽  
E. Lam
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Tobacco Mosaic Virus ◽  
Chloroplast Dna ◽  
Mosaic Virus ◽  
Hypersensitive Response ◽  
Nuclear Periphery ◽  
Death Process ◽  
Tobacco Plants ◽  
Systemic Spread

Sacrificing an infected cell or cells in order to prevent systemic spread of a pathogen appears to be a conserved strategy in both plants and animals. We studied some of the morphological and biochemical events that accompany programmed cell death during the hypersensitive response of tobacco plants infected with tobacco mosaic virus. Certain aspects of this cell death process appeared to be similar to those that take place during apoptosis in animal cells. These included condensation and vacuolization of the cytoplasm and cleavage of nuclear DNA to 50 kb fragments. In contrast, internucleosomal fragmentation, condensation of chromatin at the nuclear periphery and apoptotic bodies were not observed in tobacco plants during tobacco mosaic virus-induced hypersensitive response. A unique aspect of programmed cell death during the hypersensitive response of tobacco to tobacco mosaic virus involved an increase in the amount of monomeric chloroplast DNA. Morphological changes to the chloroplast and cytosol of tobacco cells and increase in monomeric chloroplast DNA occurred prior to gross changes in nuclear morphology and significant chromatin cleavage. Our findings suggest that certain aspects of programmed cell death may have been conserved during the evolution of plants and animals.

scholarly journals A Connected Set of Genes Associated with Programmed Cell Death Implicated in Controlling the Hypersensitive Response in Maize

Genetics ◽  
2012 ◽  
Vol 193 (2) ◽  
pp. 609-620 ◽  
Author(s):  
Bode A. Olukolu ◽  
Adisu Negeri ◽  
Rahul Dhawan ◽  
Bala P. Venkata ◽  
Pankaj Sharma ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Hypersensitive Response ◽  
Connected Set

scholarly journals Lazarus1, a DUF300 Protein, Contributes to Programmed Cell Death Associated with Arabidopsis acd11 and the Hypersensitive Response

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12586 ◽  
Author(s):  
Frederikke G. Malinovsky ◽  
Peter Brodersen ◽  
Berthe Katrine Fiil ◽  
Lea Vig McKinney ◽  
Stephan Thorgrimsen ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Hypersensitive Response

scholarly journals Cytoplasmic and Nuclear Localizations Are Important for the Hypersensitive Response Conferred by Maize Autoactive Rp1-D21 Protein

2015 ◽  
Vol 28 (9) ◽  
pp. 1023-1031 ◽  
Author(s):  
Guan-Feng Wang ◽  
Peter J. Balint-Kurti
Keyword(s):  
Cell Death ◽  
Disease Resistance ◽  
Programmed Cell Death ◽  
Hypersensitive Response ◽  
Nicotiana Benthamiana ◽  
Coiled Coil ◽  
Intragenic Recombination ◽  
R Genes ◽  
Leucine Rich Repeat ◽  
Functional Roles

Disease resistance (R) genes have been isolated from many plant species. Most encode nucleotide binding leucine-rich repeat (NLR) proteins that trigger a rapid localized programmed cell death called the hypersensitive response (HR) upon pathogen recognition. Despite their structural similarities, different NLR are distributed in a range of subcellular locations, and analogous domains play diverse functional roles. The autoactive maize NLR gene Rp1-D21 derives from an intragenic recombination between two NLR genes, Rp1-D and Rp1-dp2, and confers a HR independent of the presence of a pathogen. Rp1-D21 and its N-terminal coiled coil (CC) domain (CCD21) confer autoactive HR when transiently expressed in Nicotiana benthamiana. Rp1-D21 was predominantly localized in cytoplasm with a small amount in the nucleus, while CCD21 was localized in both nucleus and cytoplasm. Targeting of Rp1-D21 or CCD21 predominantly to either the nucleus or the cytoplasm abolished HR-inducing activity. Coexpression of Rp1-D21 or CCD21 constructs confined, respectively, to the nucleus and cytoplasm did not rescue full activity, suggesting nucleocytoplasmic movement was important for HR induction. This work emphasizes the diverse structural and subcellular localization requirements for activity found among plant NLR R genes.

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