Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

Nature ◽  
2001 ◽  
Vol 411 (6837) ◽  
pp. 613-617 ◽  
Author(s):  
Tetsuya Ohtaki ◽  
Yasushi Shintani ◽  
Susumu Honda ◽  
Hirokazu Matsumoto ◽  
Akira Hori ◽  
...  
Keyword(s):  
G Protein ◽  
Suppressor Gene ◽  
Peptide Ligand ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

2001 ◽  
Vol 276 (37) ◽  
pp. 34631-34636 ◽  
Author(s):  
Masato Kotani ◽  
Michel Detheux ◽  
Ann Vandenbogaerde ◽  
David Communi ◽  
Jean-Marie Vanderwinden ◽  
...  
Keyword(s):  
G Protein ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene ◽  
G Protein Coupled Receptor ◽  
Natural Ligands ◽  
G Protein Coupled

Mechanochemical Activation of Class-B G-Protein-Coupled Receptor upon Peptide–Ligand Binding

Nano Letters ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 5575-5582 ◽  
Author(s):  
Cristina Lo Giudice ◽  
Haonan Zhang ◽  
Beili Wu ◽  
David Alsteens
Keyword(s):  
Ligand Binding ◽  
G Protein ◽  
Mechanochemical Activation ◽  
Peptide Ligand ◽  
G Protein Coupled Receptor ◽  
Class B ◽  
G Protein Coupled

scholarly journals Cross‐Linking of a DOPA‐Containing Peptide Ligand into its G Protein‐Coupled Receptor

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
George E. Umanah ◽  
Cagdas D Son ◽  
FaXiang Ding ◽  
Fred Naider ◽  
Jeffrey M Becker
Keyword(s):  
G Protein ◽  
Cross Linking ◽  
Peptide Ligand ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms

2015 ◽  
Vol 6 (8) ◽  
pp. 872-876 ◽  
Author(s):  
Mònica Rosa ◽  
Gianluigi Caltabiano ◽  
Katy Barreto-Valer ◽  
Verónica Gonzalez-Nunez ◽  
José C. Gómez-Tamayo ◽  
...  
Keyword(s):  
G Protein ◽  
Peptide Ligand ◽  
G Protein Coupled Receptor ◽  
Halogen Atoms ◽  
G Protein Coupled

scholarly journals Identification and Characterization of a Novel RF-amide Peptide Ligand for Orphan G-protein-coupled Receptor SP9155

2003 ◽  
Vol 278 (30) ◽  
pp. 27652-27657 ◽  
Author(s):  
Ying Jiang ◽  
Lin Luo ◽  
Eric L. Gustafson ◽  
Deepmala Yadav ◽  
Maureen Laverty ◽  
...  
Keyword(s):  
G Protein ◽  
Peptide Ligand ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Identification And Characterization

scholarly journals Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand

2007 ◽  
Vol 104 (12) ◽  
pp. 4858-4863 ◽  
Author(s):  
C. R. R. Grace ◽  
M. H. Perrin ◽  
J. Gulyas ◽  
M. R. DiGruccio ◽  
J. P. Cantle ◽  
...  
Keyword(s):  
G Protein ◽  
Peptide Ligand ◽  
G Protein Coupled Receptor ◽  
Terminal Domain ◽  
G Protein Coupled

scholarly journals Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells Migration through Casein kinase 2α intronless gene

2019 ◽  
Author(s):  
Adhikarimayum Lakhikumar Sharma ◽  
Puyam Milan Meitei ◽  
Naorem Tarundas Singh ◽  
Thiyam Ramsing Singh ◽  
Lisam Shanjukumar Singh
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
G Protein ◽  
A549 Cells ◽  
Casein Kinase ◽  
Metastasis Suppressor ◽  
G Protein Coupled Receptor ◽  
Intronless Gene ◽  
First Time ◽  
G Protein Coupled

AbstractWe have previously reported that ovarian cancer G protein-coupled receptor 1 (OGR1) is a new metastasis suppressor gene. We have also reported for the first time that a new intronless gene for casein kinase 2α (CSNK2A3) is expressed in human cells. The promoter of the well-known casein kinase 2α (CSNK2A1) displays characteristics of housekeeping gene whereas CSNK2A3 has a characteristic of a regulated promoter with two TATA boxes and a CAAT box. In this study, we found that OGR1 up-regulates expression of CSNK2A3 by about 3 folds in A549 cells but not CSNK2A1. OGR1 also up-regulates expression of neutral endopeptidase (NEP). The OGR1 induced inhibition of A549 cell migration is completely abrogated by inhibition of casein kinase 2α activity, whereas partial abrogation (~ 30%) was observed in the presence of NEP inhibition. The results also revealed that OGR1 regulates CSNK2A3 via activation of Rac1/cdc42 and MAPKs pathways. CK2 is ubiquitously expressed and in contrast it is believed to be a constitutively active enzyme and its regulation appears to be independent of known second messengers. There is no previous report on how expression of CK2α in cancer cells is regulated although many studies have report of aberrant expression of the kinase in cancer. In the current study, we are reporting for the first time the regulation of intronless casein kinase 2α gene, CSNK2A3 in cancer cells. Our findings suggest that the aberrantly casein kinase 2α expression found in various cancer cells may the due to CSNK2A3 expression which is potentially regulated by several master regulators of the developmental pathways rather than well-known casein kinase 2α gene, CSNK2A1.

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