Somatic control over the germline stem cell lineage during Drosophila spermatogenesis

Nature ◽  
2000 ◽  
Vol 407 (6805) ◽  
pp. 754-757 ◽  
Author(s):  
John Tran ◽  
Tamara J. Brenner ◽  
Stephen DiNardo
Keyword(s):  
Stem Cell ◽  
Cell Lineage ◽  
Germline Stem Cell ◽  
Stem Cell Lineage

scholarly journals Three RNA Binding Proteins Form a Complex to Promote Differentiation of Germline Stem Cell Lineage in Drosophila

PLoS Genetics ◽  
2014 ◽  
Vol 10 (11) ◽  
pp. e1004797 ◽  
Author(s):  
Di Chen ◽  
Chan Wu ◽  
Shaowei Zhao ◽  
Qing Geng ◽  
Yu Gao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Cell Lineage ◽  
Germline Stem Cell ◽  
Stem Cell Lineage

scholarly journals Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways

Cell Reports ◽  
2015 ◽  
Vol 13 (7) ◽  
pp. 1366-1379 ◽  
Author(s):  
Ziwen Fu ◽  
Cuiyun Geng ◽  
Hui Wang ◽  
Zhihao Yang ◽  
Changjiang Weng ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Lineage ◽  
Germline Stem Cell ◽  
Stem Cell Lineage

scholarly journals Stem Cells, Diet, and Physiology

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-740
Author(s):  
Daniela Drummond-Barbosa
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Lineage ◽  
Germline Stem Cell ◽  
Stem Cell Regulation ◽  
Stem Cell Lineage ◽  
Sensor Control ◽  
Nutrient Signaling ◽  
Multicellular Organisms

Abstract Nutrient availability, stresses, and aging affect tissue stem cells in multicellular organisms; yet, the underlying physiological mechanisms in vivo remains largely unexplored. Dr. Drummond-Barbosa pioneered using Drosophila to study the physiology of tissue stem cell regulation. Her laboratory played a major role in delineating how diet, brain insulin-like peptides, and the TOR nutrient sensor control the germline stem cell (GSC) lineage. They also discovered that adipocyte-specific disruption of amino acid transport, other nutrient signaling, and metabolic pathways causes distinct germline phenotypes. They also showed that nuclear receptors act in multiple tissues to affect the GSC lineage through direct and indirect mechanisms. More recently, her group has been exploring how other physiological stresses affect the GSC lineage. Her group’s studies point to extensive communication between the brain, adipocytes, hepatocyte-like cells, and the germline, and underscore the complexity of the physiological network that modulates stem cell lineage behavior.

bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis

Development ◽  
1997 ◽  
Vol 124 (21) ◽  
pp. 4361-4371 ◽  
Author(s):  
P. Gonczy ◽  
E. Matunis ◽  
S. DiNardo
Keyword(s):  
Stem Cell ◽  
Germ Cells ◽  
Daughter Cell ◽  
Cell Lineage ◽  
Germline Stem Cell ◽  
Cell Lineages ◽  
Male Germline ◽  
Stem Cell Lineage ◽  
Cell Neoplasm ◽  
Bag Of Marbles

Stem cells divide asymmetrically, regenerating a parental stem cell and giving rise to a daughter cell with a distinct fate. In many stem cell lineages, this daughter cell undergoes several amplificatory mitoses, thus generating more cells that embark on the differentiation program specific for the given lineage. Spermatogenesis in Drosophila is a model system to identify molecules regulating stem cell lineages. Mutations at two previously identified loci, bag-of-marbles (bam) and benign gonial cell neoplasm (bgcn), prevent progression through spermatogenesis and oogenesis, resulting in the overproliferation of undifferentiated germ cells. Here we investigate how bam and bgcn regulate the male germline stem cell lineage. By generating FLP-mediated clones, we demonstrate that both bam and bgcn act autonomously in the germline to restrict proliferation during spermatogenesis. By using enhancer trap lines, we find that the overproliferating germ cells express markers specific to amplifying germ cells, while at the same time retaining the expression of some markers of stem cell and primary spermatogonial cell fate. However, we find that germ cells accumulating in bam or bgcn mutant testes most resemble amplifying germ cells, because they undergo incomplete cytokinesis and progress through the cell cycle in synchrony within a cyst, which are two characteristics of amplifying germ cells, but not of stem cells. Taken together, our results suggest that bam and bgcn regulate progression through the male germline stem cell lineage by cell-intrinsically restricting the proliferation of amplifying germ cells.

scholarly journals Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in Drosophila melanogaster

Genetics ◽  
2017 ◽  
Vol 206 (2) ◽  
pp. 953-971 ◽  
Author(s):  
Shinya Matsuoka ◽  
Alissa R. Armstrong ◽  
Leesa L. Sampson ◽  
Kaitlin M. Laws ◽  
Daniela Drummond-Barbosa
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Metabolic Pathways ◽  
Cell Lineage ◽  
Germline Stem Cell ◽  
Stem Cell Lineage ◽  
Diet Control ◽  
Female Germline

scholarly journals Single-cyst transcriptome analysis of Drosophila male germline stem cell lineage

Development ◽  
2020 ◽  
Vol 147 (8) ◽  
pp. dev184259 ◽  
Author(s):  
Zhen Shi ◽  
Cindy Lim ◽  
Vuong Tran ◽  
Kairong Cui ◽  
Keji Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcriptome Analysis ◽  
Cell Lineage ◽  
Germline Stem Cell ◽  
Single Cyst ◽  
Male Germline ◽  
Stem Cell Lineage
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