AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Nature ◽  
2000 ◽  
Vol 404 (6779) ◽  
pp. 782-787 ◽  
Author(s):  
René H. Medema ◽  
Geert J. P. L. Kops ◽  
Johannes L. Bos ◽  
Boudewijn M. T. Burgering
Keyword(s):  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Forkhead Transcription Factors ◽  
Mediate Cell ◽  
Cycle Regulation

scholarly journals 14-3-3 proteins: a family of versatile molecular regulators

2008 ◽  
pp. S11-S21
Author(s):  
V Obšilová ◽  
J Šilhan ◽  
E Bouřa ◽  
J Teisinger ◽  
T Obšil
Keyword(s):  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Molecular Scaffolds ◽  
Forkhead Transcription Factors ◽  
Binding Partners ◽  
Wide Range ◽  
Functional Modulation ◽  
Cycle Regulation ◽  
And Control

The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.

scholarly journals Phosphorylation-Dependent Protein Interactions at the Spindle Midzone Mediate Cell Cycle Regulation of Spindle Elongation

2009 ◽  
Vol 17 (2) ◽  
pp. 244-256 ◽  
Author(s):  
Anton Khmelinskii ◽  
Johanna Roostalu ◽  
Helio Roque ◽  
Claude Antony ◽  
Elmar Schiebel
Keyword(s):  
Cell Cycle ◽  
Protein Interactions ◽  
Cell Cycle Regulation ◽  
Spindle Midzone ◽  
Dependent Protein ◽  
Spindle Elongation ◽  
Mediate Cell ◽  
Cycle Regulation

scholarly journals G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1

2003 ◽  
Vol 23 (14) ◽  
pp. 5064-5077 ◽  
Author(s):  
Michael Costanzo ◽  
Oliver Schub ◽  
Brenda Andrews
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Cycle ◽  
Transcription Factors ◽  
Transcriptional Activation ◽  
Chromatin Immunoprecipitation ◽  
Cell Cycle Regulation ◽  
Binding Protein ◽  
Microarray Studies ◽  
Cycle Regulation ◽  
Integral Feature

ABSTRACT Stage-specific transcriptional programs are an integral feature of cell cycle regulation. In the budding yeast Saccharomyces cerevisiae, over 120 genes are coordinately induced in late G1 phase by two heterodimeric transcription factors called SBF and MBF. Activation of SBF and MBF is an upstream initiator of key cell cycle events, including budding and DNA replication. SBF and MBF regulation is complex and genetically redundant, and the precise mechanism of G1 transcriptional activation is unclear. Assays using SBF- and MBF-specific reporter genes revealed that the STB1 gene specifically affected MBF-dependent transcription. STB1 encodes a known Swi6-binding protein, but an MBF-specific function had not been previously suspected. Consistent with a specific role in regulating MBF, a STB1 deletion strain requires SBF for viability and microarray studies show a decrease in MBF-regulated transcripts in a swi4Δ mutant following depletion of Stb1. Chromatin immunoprecipitation experiments confirm that Stb1 localizes to promoters of MBF-regulated genes. Our data indicate that, contrary to previous models, MBF and SBF have unique components and might be distinctly regulated.

FOXO Transcription Factors in Cell-Cycle Regulation and the Response to Oxidative Stress

2005 ◽  
Vol 7 (5-6) ◽  
pp. 752-760 ◽  
Author(s):  
Yoko Furukawa-Hibi ◽  
Yosuke Kobayashi ◽  
Chen Chen ◽  
Noboru Motoyama
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Foxo Transcription Factors ◽  
Cycle Regulation

scholarly journals Kinase Regulation of HOX Transcription Factors

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 508 ◽  
Author(s):  
Monika Primon ◽  
Keith D. Hunter ◽  
Hardev S. Pandha ◽  
Richard Morgan
Keyword(s):  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Hox Genes ◽  
Integration Site ◽  
Cell Leukaemia ◽  
Early Event ◽  
Cell Renewal ◽  
Hox Proteins ◽  
Cycle Regulation

The HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is frequently re-established as an early event in tumour formation and supports an oncogenic phenotype. HOX transcription factors are also involved in cell cycle regulation and DNA repair, along with normal adult physiological process including stem cell renewal. There have been extensive studies on the mechanism by which HOX proteins regulate transcription, with particular emphasis on their interaction with cofactors such as Pre-B-cell Leukaemia Homeobox (PBX) and Myeloid Ecotropic Viral Integration Site 1 (MEIS). However, significantly less is known of how the activity of HOX proteins is regulated. There is growing evidence that phosphorylation may play an important role in this context, and in this review, we draw together a number of important studies published over the last 20 years, and discuss the relevance of phosphorylation in the regulation and function of HOX proteins in development, evolution, cell cycle regulation, and cancer.

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