Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6

Nature ◽  
1991 ◽  
Vol 349 (6309) ◽  
pp. 533-535 ◽  
Author(s):  
Paolo Lusso ◽  
Andrea De Maria ◽  
Mauro Malnati ◽  
Franco Lori ◽  
Susan E. DeRocco ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Cd8 T Lymphocytes ◽  
Herpesvirus 6 ◽  
Hiv 1

scholarly journals In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6).

1988 ◽  
Vol 167 (5) ◽  
pp. 1659-1670 ◽  
Author(s):  
P Lusso ◽  
P D Markham ◽  
E Tschachler ◽  
F di Marzo Veronese ◽  
S Z Salahuddin ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Cell Population ◽  
Mononuclear Cells ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Infected Cells ◽  
Cellular Tropism ◽  
Herpesvirus 6

We investigated the cellular tropism of human B-lymphotropic virus (HBLV) (also designated Human Herpesvirus-6) in vitro by infecting fresh MN cells from normal human adult peripheral blood, umbilical cord blood, bone marrow, tonsil, and thymus. Cultures from all the sources examined contained infectable cells, as shown by the appearance of characteristic enlarged, round-shaped, short-lived cells expressing HBLV-specific markers. Detailed immunological analysis demonstrated that the vast majority of these cells expressed T cell-associated antigens (i.e., CD7, CD5, CD2, CD4, and to a lesser extent, CD8). The CD3 antigen and the TCR-alpha/beta heterodimer were not detectable on the surface membrane, but were identified within the cytoplasm of HBLV-infected cells, by both immunofluorescence and radioimmunoprecipitation assay. A proportion of the HBLV-infected cell population also expressed the CD15 and class II MHC DR antigens. By means of immunoselection procedures it was possible to show that a consistent proportion of HBLV-infectable cells were contained within the CD3-depleted immature T cell population, while the depletion of CD2+ cells completely abrogated the infectability of the cultures. Northern blot analysis confirmed the T cell origin of HBLV-infected cells, demonstrating the expression of full size TCR-alpha and -beta chain mRNA. In addition to fresh T cells, HBLV was able to infect normal T lymphocytes expanded in vitro with IL-2 for greater than 30 d. These results indicate that HBLV is selectively T cell tropic in the course of the in vitro infection of normal mononuclear cells and may therefore be directly involved in the pathogenesis of T cell related hematological disorders. In particular, in light of the cytopathic effect exerted in vitro on CD4+ T lymphocytes, a possible role of HBLV in immune deficiency conditions should be considered.

Human herpesvirus-6 reactivation in a longitudinal study of two HIV-1 infected patients

1997 ◽  
Vol 51 (4) ◽  
pp. 259-264 ◽  
Author(s):  
Rodolfo Iuliano ◽  
Raffaella Trovato ◽  
Salvatore Lico ◽  
Mario Luppi ◽  
Giuseppe Forastieri ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Hiv 1

scholarly journals Phenotypic and Functional Alterations of Dendritic Cells Induced by Human Herpesvirus 6 Infection

2002 ◽  
Vol 76 (20) ◽  
pp. 10338-10345 ◽  
Author(s):  
Miki Kakimoto ◽  
Atsuhiko Hasegawa ◽  
Shigeru Fujita ◽  
Masaki Yasukawa
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Antigen Processing ◽  
Human Herpesvirus ◽  
Hla Class I ◽  
Class Ii ◽  
Human Herpesvirus 6 ◽  
Antigen Capture ◽  
Processing Pathways ◽  
Herpesvirus 6

ABSTRACT Human herpesvirus 6 (HHV-6) has a tropism for T lymphocytes and monocytes/macrophages, suggesting that HHV-6 infection affects the immunosurveillance system. In the present study, we investigated the HHV-6-induced phenotypic and functional alterations of dendritic cells (DCs), which are professional antigen-presenting cells. HHV-6 infection of monocyte-derived immature DCs appeared to induce the up-regulation of CD80, CD83, CD86, and HLA class I and class II molecules, suggesting that HHV-6 infection induces the maturation of DCs. In addition, the antigen capture capacity of DCs was found to decrease following infection with HHV-6. In contrast to up-regulation of mature-DC-associated surface molecules on HHV-6-infected DCs, their capacity for presentation of alloantigens and exogenous virus antigens to T lymphocytes decreased significantly from that of uninfected DCs. In contrast, there appeared to be no reduction in the capacity for presentation of an HLA class II-binding peptide to the peptide-specific CD4+ T lymphocytes. These data indicate that HHV-6 infection induces phenotypic alterations and impairs the antigen presentation capacity of DCs. The present data also suggest that the dysfunction of HHV-6-infected DCs is attributable mainly to impairment of the antigen capture and intracellular antigen-processing pathways.

ANTIBODY TO HUMAN HERPESVIRUS 6 IN HIV-1 POSITIVE AND NEGATIVE HOMOSEXUAL MEN

The Lancet ◽  
1988 ◽  
Vol 332 (8607) ◽  
pp. 396-397 ◽  
Author(s):  
Julie Fox ◽  
Moya Briggs ◽  
R.S. Tedder
Keyword(s):  
Human Herpesvirus ◽  
Homosexual Men ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Hiv 1

scholarly journals In Vitro and In Vivo Transactivation of HIV-1 by Human Herpesvirus 6

10.5772/19778 ◽  
2011 ◽  
Author(s):  
Ongradi Joseph ◽  
Kovesdi Valeria ◽  
Nagy Karoly ◽  
Matteoli Barbara ◽  
Ceccherini-Nelli Luca ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Hiv 1

scholarly journals Coinfection of SCID-hu Thy/Liv Mice with Human Herpesvirus 6 and Human Immunodeficiency Virus Type 1

2000 ◽  
Vol 74 (18) ◽  
pp. 8726-8731 ◽  
Author(s):  
Alberto Gobbi ◽  
Cheryl A. Stoddart ◽  
Giuseppe Locatelli ◽  
Fabio Santoro ◽  
Christopher Bare ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Immunodeficiency Virus ◽  
Herpesvirus 6 ◽  
Hiv 1

ABSTRACT Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.

Transcriptional Activation of Minimal HIV-1 Promoter by ORF-1 Protein Expressed from the SalI-L Fragment of Human Herpesvirus 6

Virology ◽  
1994 ◽  
Vol 201 (1) ◽  
pp. 95-106 ◽  
Author(s):  
Fatah Kashanchi ◽  
Jerry Thompson ◽  
M.Reza Sadaie ◽  
Jay Doniger ◽  
Janet Duvall ◽  
...  
Keyword(s):  
Transcriptional Activation ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Hiv 1

Reciprocal in vitro interactions between human herpesvirus-6 and HIV-1 Tat

AIDS ◽  
1991 ◽  
Vol 5 (9) ◽  
pp. 1095-1098 ◽  
Author(s):  
Dario Di Luca ◽  
Paola Secchiero ◽  
Pasqualina Bovenzi ◽  
Antonella Rotola ◽  
Antonella Caputo ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Hiv 1 ◽  
In Vitro Interactions
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