The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

Nature ◽  
1991 ◽  
Vol 349 (6304) ◽  
pp. 84-87 ◽  
Author(s):  
D. P. Barlow ◽  
R. Stöger ◽  
B. G. Herrmann ◽  
K. Saito ◽  
N. Schweifer
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor Type

Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2: a rare entity

2014 ◽  
Vol 14 (2) ◽  
pp. 170-180 ◽  
Author(s):  
R. Finotello ◽  
L. Ressel ◽  
M. Arvigo ◽  
G. Baroni ◽  
V. Marchetti ◽  
...  
Keyword(s):  
Growth Factor ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Insulin Like Growth Factor ◽  
Rare Entity ◽  
Pancreatic Islet Cell ◽  
Islet Cell Tumours ◽  
Factor Type

Regional distribution of messenger RNA encoding the insulin-like growth factor type 2 receptor in the rat lower brainstem

1995 ◽  
Vol 32 (1) ◽  
pp. 14-24 ◽  
Author(s):  
Takashi Nagano ◽  
Makoto Sato ◽  
Yasutake Mori ◽  
Yanjun Du ◽  
Hiroshi Takagi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Messenger Rna ◽  
Regional Distribution ◽  
Insulin Like Growth Factor ◽  
Factor Type

scholarly journals Identification of cation-independent mannose 6-phosphate receptor/insulin-like growth factor type-2 receptor as a novel target of autoantibodies

Immunology ◽  
1999 ◽  
Vol 98 (4) ◽  
pp. 652-662 ◽  
Author(s):  
D. Tarrago ◽  
I. Aguilera ◽  
J. Melero ◽  
I. Wichmann ◽  
A. Nunez-roldan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Mannose 6 Phosphate ◽  
Factor Type ◽  
Novel Target

scholarly journals Cooperative Repression of Insulin-Like Growth Factor Type 2 Receptor Translation by MicroRNA 195 and RNA-Binding Protein CUGBP1

2017 ◽  
Vol 37 (19) ◽  
Author(s):  
Yuan Zhang ◽  
Yun Zhang ◽  
Lan Xiao ◽  
Ting-Xi Yu ◽  
Jun-Zhe Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mammalian Cells ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Type ◽  
Mucosal Adaptation ◽  
The Stability

ABSTRACT Insulin-like growth factor type 2 (IGF2) receptor (IGF2R) recognizes mannose 6-phosphate-containing molecules and IGF2 and plays an important role in many pathophysiological processes, including gut mucosal adaptation. However, the mechanisms that control cellular IGF2R abundance are poorly known. MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) critically regulate gene expression programs in mammalian cells by modulating the stability and translation of target mRNAs. Here we report that miRNA 195 (miR-195) and RBP CUG-binding protein 1 (CUGBP1) jointly regulate IGF2R expression at the posttranscriptional level in intestinal epithelial cells. Both miR-195 and CUGBP1 interacted with the 3′ untranslated region (3′-UTR) of Igf2r mRNA, and the association of CUGBP1 with Igf2r mRNA enhanced miR-195 binding to Igf2r mRNA. Ectopically expressed CUGBP1 and miR-195 repressed IGF2R translation cooperatively without altering the stability of Igf2r mRNA. Importantly, the miR-195- and CUGBP1-repressed levels of cellular IGF2R led to a disruption in the structure of the trans-Golgi network. These findings indicate that IGF2R expression is controlled posttranscriptionally by two factors that associate with Igf2r mRNA and suggest that miR-195 and CUGBP1 dampen IGF signaling by inhibiting IGF2R translation.

The insulin–like growth factor type–2 receptor gene is imprinted in the mouse but not in humans

1993 ◽  
Vol 5 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Vera M. Kalscheuer ◽  
Edwin C. Mariman ◽  
Marga T. Schepens ◽  
Helga Rehder ◽  
Hans-Hilger Ropers
Keyword(s):  
Growth Factor ◽  
Receptor Gene ◽  
Insulin Like Growth Factor ◽  
Factor Type

1559-P: Differential Effects of Type 1 (T1D) and Type 2 Diabetes (T2D) on the Growth Hormone (GH)-Insulin-Like Growth Factor (IGF) Axis in Youth

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1559-P
Author(s):  
JANET K. SNELL-BERGEON ◽  
JANE E.B. REUSCH ◽  
AMY D. BAUMGARTNER ◽  
MELANIE CREE-GREEN ◽  
KRISTEN J. NADEAU
Keyword(s):  
Type 2 Diabetes ◽  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Differential Effects
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