Activation of facilitation calcium channels in chromaffin cells by D1 dopamine receptors through a cAMP/protein kinase A-dependent mechanism

Nature ◽  
1990 ◽  
Vol 348 (6298) ◽  
pp. 239-242 ◽  
Author(s):  
Cristina R. Artalejo ◽  
Marjorie A. Ariano ◽  
Robert L. Perlman ◽  
Aaron P. Fox
Keyword(s):  
Protein Kinase ◽  
Calcium Channels ◽  
Protein Kinase A ◽  
Dopamine Receptors ◽  
Chromaffin Cells ◽  
D1 Dopamine Receptors ◽  
Kinase A ◽  
Dependent Mechanism

A cyclic AMP protein kinase A-dependent mechanism by which rotavirus impairs the expression and enzyme activity of brush border-associated sucrase-isomaltase in differentiated intestinal Caco-2 cells

2004 ◽  
Vol 6 (8) ◽  
pp. 719-731 ◽  
Author(s):  
Sandra Martin-Latil ◽  
Jacqueline Cotte-Laffitte ◽  
Isabelle Beau ◽  
Anne-Marie Quéro ◽  
Monique Géniteau-Legendre ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Protein Kinase A ◽  
Brush Border ◽  
Kinase A ◽  
Dependent Mechanism

scholarly journals Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A

2014 ◽  
Vol 307 (3) ◽  
pp. C266-C277 ◽  
Author(s):  
Shaima Salman ◽  
Alison C. Holloway ◽  
Colin A. Nurse
Keyword(s):  
Protein Kinase ◽  
Carbonic Anhydrase ◽  
Protein Kinase A ◽  
Chromaffin Cells ◽  
Time Course ◽  
Molecular Mechanisms ◽  
Hypoxia Inducible Factor ◽  
Neonatal Rat ◽  
Pcr Analysis ◽  
Kinase A

At birth, asphyxial stressors such as hypoxia and hypercapnia are important physiological stimuli for adrenal catecholamine release that is critical for the proper transition to extrauterine life. We recently showed that chronic opioids blunt chemosensitivity of neonatal rat adrenomedullary chromaffin cells (AMCs) to hypoxia and hypercapnia. This blunting was attributable to increased ATP-sensitive K+ (KATP) channel and decreased carbonic anhydrase (CA) I and II expression, respectively, and involved μ- and δ-opioid receptor signaling pathways. To address underlying molecular mechanisms, we first exposed an O2- and CO2-sensitive, immortalized rat chromaffin cell line (MAH cells) to combined μ {[d-Arg2,Ly4]dermorphin-(1–4)-amide}- and δ ([d-Pen2,5,P-Cl-Phe4]enkephalin)-opioid agonists (2 μM) for ∼7 days. Western blot and quantitative real-time PCR analysis revealed that chronic opioids increased KATP channel subunit Kir6.2 and decreased CAII expression; both effects were blocked by naloxone and were absent in hypoxia-inducible factor (HIF)-2α-deficient MAH cells. Chronic opioids also stimulated HIF-2α accumulation along a time course similar to Kir6.2. Chromatin immunoprecipitation assays on opioid-treated cells revealed the binding of HIF-2α to a hypoxia response element in the promoter region of the Kir6.2 gene. The opioid-induced regulation of Kir6.2 and CAII was dependent on protein kinase A, but not protein kinase C or calmodulin kinase, activity. Interestingly, a similar pattern of HIF-2α, Kir6.2, and CAII regulation (including downregulation of CAI) was replicated in chromaffin tissue obtained from rat pups born to dams exposed to morphine throughout gestation. Collectively, these data reveal novel mechanisms by which chronic opioids blunt asphyxial chemosensitivity in AMCs, thereby contributing to abnormal arousal responses in the offspring of opiate-addicted mothers.

Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells

2015 ◽  
Vol 93 (3) ◽  
pp. 362-369 ◽  
Author(s):  
Karl-Friedrich Beck ◽  
Johannes Euler ◽  
Florian Eisel ◽  
Martina Beck ◽  
Yvette Köhler ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Mesangial Cells ◽  
Kinase A ◽  
Dependent Mechanism

scholarly journals Protein kinase A modulation of CaV1.4 calcium channels

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Lingjie Sang ◽  
Ivy E. Dick ◽  
David T. Yue
Keyword(s):  
Protein Kinase ◽  
Calcium Channels ◽  
Protein Kinase A ◽  
Kinase A

scholarly journals Up-regulation ofpermRNA Expression by Parathyroid Hormone through a Protein Kinase A-CREB-dependent Mechanism in Chondrocytes

2006 ◽  
Vol 281 (33) ◽  
pp. 23632-23642 ◽  
Author(s):  
Eiichi Hinoi ◽  
Taichi Ueshima ◽  
Hironori Hojo ◽  
Mika Iemata ◽  
Takeshi Takarada ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Kinase A ◽  
Dependent Mechanism
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