scholarly journals Compound Q

Nature ◽  
1990 ◽  
Vol 343 (6256) ◽  
pp. 304-304
Author(s):  
MICHAEL S. MCGRATH ◽  
JEFFREY D. LIFSON
Keyword(s):  
Compound Q

scholarly journals Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast Candida albicans

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 638
Author(s):  
M. Joana F. Pinheiro ◽  
Joana P. Costa ◽  
Fernanda Marques ◽  
Nuno P. Mira ◽  
M. Fernanda N. N. Carvalho ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Medical Devices ◽  
Mammalian Cells ◽  
Surface Engineering ◽  
Pathogenic Yeast ◽  
Bioactive Coatings ◽  
Clinical Strains ◽  
Persistent Infections ◽  
Compound Q ◽  
Significant Step

Currently there is a gap between the rate of new antifungal development and the emergence of resistance among Candida clinical strains, particularly threatened by the extreme adhesiveness of C. albicans to indwelling medical devices. Two silver camphorimine complexes, [Ag(OH){OC10H14N(C6H4)2NC10H14O}] (compound P) and [{Ag(OC10H14NC6H4CH3-p)}2(μ-O)] (compound Q), are herein demonstrated as having high inhibiting activity towards the growth of Candida albicans and Candida glabrata clinical strains resistant to azoles, the frontline antifungals used in clinical practice. Compounds P and Q were also explored as bioactive coatings to prevent colonization by C. albicans and colonize the surface of indwelling medical devices, resulting in persistent infections. Functionalization of stainless steel with polycaprolactone (PCL) matrix embedded with compounds P or Q was reported for the first time to inhibit the colonization of C. albicans by 82% and 75%, respectively. The coating of PCL loaded with Q or P did not cause cytotoxic effects in mammalian cells, demonstrating the biocompatibility of the explored approach. The identification and further exploration of new approaches for surface engineering based on new molecules that can sensitize resistant strains, as herein demonstrated for complexes P and Q, is a significant step forward to improve the successful treatment of candidiasis.

Effects of certain quinones on renal excretion of sodium

1963 ◽  
Vol 205 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Stephen W. Weinstein ◽  
Richard H. Kessler
Keyword(s):  
Electron Transport ◽  
Transport System ◽  
Renal Excretion ◽  
Coenzyme Q ◽  
Electron Transport System ◽  
Sodium Reabsorption ◽  
Moderate Increase ◽  
Compound Q ◽  
Sodium Load ◽  
Renal Clearances

Coenzyme Q (Q10), an essential of the electron transport system, is located between flavoprotein and the cytochromes. Coenzyme Q consists of a benzoquinone nucleus, having one methyl, an aliphatic and two methoxy constituents. We have attempted to inhibit renal coenzyme Q by the administration of several structural variants directly into one renal artery. Ureteral urines were collected separately for measurement of sodium excretion and renal clearances. Unilateral natriuresis was observed only with aqueous soluble benzoquinones in the oxidized state. The infusion of .001 mmole of one such compound (Q0) was sufficient to block reabsorption of 17% of the filtered sodium load. Natriuresis did not occur with either reduced quinones or those having a long-chain aliphatic constituent. A moderate increase in the renal clearances of creatinine and PAH was typically, but not invariably, observed. These results suggest that Q0 blocks the electron transport system and, therefore, some fraction of sodium reabsorption by competitively inhibiting coenzyme Q. This effect may be mediated through energy metabolism.

Methane monooxygenase and compound Q: lessons in oxygen activation

2002 ◽  
Vol 1233 ◽  
pp. 205-212 ◽  
Author(s):  
John D Lipscomb ◽  
Brian J Brazeau ◽  
Bradley J Wallar
Keyword(s):  
Methane Monooxygenase ◽  
Oxygen Activation ◽  
Compound Q

Compound Q

1990 ◽  
Vol 15 (6) ◽  
pp. 566
Author(s):  
J. Prous ◽  
J. Castañer
Keyword(s):  
Compound Q

COMPOUND Q CLINICAL TESTS BEGIN

1989 ◽  
Vol 89 (7) ◽  
pp. 916
Author(s):  
Louise Katzin
Keyword(s):  
Clinical Tests ◽  
Compound Q

scholarly journals Compound Q is finally deciphered

2015 ◽  
Vol 2 (9) ◽  
pp. 824-826 ◽  
Author(s):  
Ambika Bhagi-Damodaran ◽  
Yi Lu
Keyword(s):  
Methane Monooxygenase ◽  
Compound Q

The elusive compound Q in methane monooxygenase has been characterised and firmly established as a diamond-core bis-μ-oxo FeIV FeIV cluster.

Book Reviews: Two Recent Books on Traditional Chinese Medicine and AIDS

1991 ◽  
Vol 19 (02) ◽  
pp. 177-188
Author(s):  
Shiu Ying Hu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Harvard University ◽  
Herbal Products ◽  
Chinese Herbal ◽  
Extensive Field ◽  
Compound Q ◽  
Future Improvement ◽  
The Usa

The development of a purified and crystallized protein called trichosanthin, used in China for inducing abortion, and imported into the USA for curing AIDS infection under the name "compound Q," is carefully reviewed. Another book on the use of the principles and practices of traditional Chinese medicine for the health care of AIDS patients is critically reviewed with a few suggestions for future improvement in respect to Chinese herbal products. The reviewer has worked on the medicinal plants of China since 1935, with extensive field experience of botanization throughout China, from the coastal provinces to the Qinghai-Tibetan Plateau, and from Heilungjian to Yunnan; and with the herbaria and library facilities of Harvard University since 1945.

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