Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

Nature ◽  
1987 ◽  
Vol 329 (6139) ◽  
pp. 539-541 ◽  
Author(s):  
Masatsugu Ohta ◽  
Joel S. Greenberger ◽  
Pervin Anklesaria ◽  
Anna Bassols ◽  
Joan Massagué
Keyword(s):  
Growth Factor ◽  
Progenitor Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Human telomerase is regulated by erythropoietin and transforming growth factor-β in human erythroid progenitor cells

Leukemia ◽  
2007 ◽  
Vol 21 (11) ◽  
pp. 2304-2310 ◽  
Author(s):  
N Prade-Houdellier ◽  
E Frébet ◽  
C Demur ◽  
E-F Gautier ◽  
F Delhommeau ◽  
...  
Keyword(s):  
Growth Factor ◽  
Progenitor Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Erythroid Progenitor ◽  
Erythroid Progenitor Cells ◽  
Human Telomerase

scholarly journals BF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners

2000 ◽  
Vol 20 (17) ◽  
pp. 6201-6211 ◽  
Author(s):  
Changlin Dou ◽  
Jun Lee ◽  
Bo Liu ◽  
Fang Liu ◽  
Joan Massague ◽  
...  
Keyword(s):  
Growth Factor ◽  
Dna Binding ◽  
Growth Inhibition ◽  
Progenitor Cells ◽  
Transcriptional Activation ◽  
Transforming Growth Factor ◽  
Ectopic Expression ◽  
Transforming Growth Factor Β ◽  
Reporter System ◽  
Transcriptional Responses

ABSTRACT The winged-helix (WH) BF-1 gene, which encodes brain factor 1 (BF-1) (also known as foxg1), is essential for the proliferation of the progenitor cells of the cerebral cortex. Here we show that BF-1-deficient telencephalic progenitor cells are more apt to leave the cell cycle in response to transforming growth factor β (TGF-β) and activin. We found that ectopic expression of BF-1 in vitro inhibits TGF-β mediated growth inhibition and transcriptional activation. Surprisingly, we found that the ability of BF-1 to function as a TGF-β antagonist does not require its DNA binding activity. Therefore, we investigated whether BF-1 can inhibit Smad-dependent transcriptional responses by interacting with Smads or Smad binding partners. We found that BF-1 does not interact with Smads. Because the identities of the Smad partners mediating growth inhibition by TGF-β are not clearly established, we examined a model reporter system which is known to be activated by activin and TGF-β through Smads and the WH factor FAST-2. We demonstrate that BF-1 associates with FAST-2. This interaction is dependent on the same region of protein which mediates its ability to interfere with the antiproliferative activity of TGF-β and with TGF-β-dependent transcriptional activation. Furthermore, the interaction of FAST-2 with BF-1 is mediated by the same domain which is required for FAST-2 to interact with Smad2. We propose a model in which BF-1 interferes with transcriptional responses to TGF-β by interacting with FAST-2 or with other DNA binding proteins which function as Smad2 partners and which have a common mode of interaction with Smad2.

scholarly journals The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours

2014 ◽  
Vol 44 (4) ◽  
pp. 1015-1022 ◽  
Author(s):  
ELIENE BOGAERTS ◽  
FEMKE HEINDRYCKX ◽  
YVES-PAUL VANDEWYNCKEL ◽  
LEO A. VAN GRUNSVEN ◽  
HANS VAN VLIERBERGHE
Keyword(s):  
Growth Factor ◽  
Progenitor Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Liver Tumours ◽  
Primary Liver Tumours

scholarly journals Role of transforming growth factor β signaling and expansion of progenitor cells in regenerating liver

Hepatology ◽  
2009 ◽  
Vol 51 (4) ◽  
pp. 1373-1382 ◽  
Author(s):  
Arun Thenappan ◽  
Ying Li ◽  
Krit Kitisin ◽  
Asif Rashid ◽  
Kirti Shetty ◽  
...  
Keyword(s):  
Growth Factor ◽  
Progenitor Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Regenerating Liver
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