Cytokine-induced pseudopodial protrusion is coupled to tumour cell migration

Nature ◽  
1987 ◽  
Vol 329 (6136) ◽  
pp. 261-263 ◽  
Author(s):  
Raouf Guirguis ◽  
Inger Margulies ◽  
Giulia Taraboletti ◽  
Elliott Schiffmann ◽  
Lance Liotta
Keyword(s):  
Cell Migration ◽  
Tumour Cell

Tumour cell migration in adamantinomatous craniopharyngiomas is promoted by activated Wnt-signalling

2010 ◽  
Vol 119 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Annett Hölsken ◽  
Michael Buchfelder ◽  
Rudolf Fahlbusch ◽  
Ingmar Blümcke ◽  
Rolf Buslei
Keyword(s):  
Cell Migration ◽  
Tumour Cell ◽  
Wnt Signalling

scholarly journals Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Hasini Jayatilaka ◽  
Pranay Tyle ◽  
Jonathan J. Chen ◽  
Minsuk Kwak ◽  
Julia Ju ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumour Cell ◽  
Signalling Pathway ◽  
Paracrine Signalling

125 Beta-blockers inhibit tumour cell migration: a potential use as anti-metastatic drugs

2010 ◽  
Vol 8 (5) ◽  
pp. 33
Author(s):  
F. Entschladen ◽  
M.J. Voss ◽  
K.S. Zänker ◽  
B. Niggemann ◽  
D. Palm ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumour Cell ◽  
Beta Blockers ◽  
Potential Use

scholarly journals Ion channels and transporters in tumour cell migration and invasion

2014 ◽  
Vol 369 (1638) ◽  
pp. 20130102 ◽  
Author(s):  
Albrecht Schwab ◽  
Christian Stock
Keyword(s):  
Cell Migration ◽  
Ion Channels ◽  
Ion Transport ◽  
Tumour Cell ◽  
Transport Proteins ◽  
Migration And Invasion ◽  
Central Component ◽  
Cell Migration And Invasion ◽  
Candidate Target ◽  
Cytoskeletal Elements

Cell migration is a central component of the metastatic cascade requiring a concerted action of ion channels and transporters (migration-associated transportome), cytoskeletal elements and signalling cascades. Ion transport proteins and aquaporins contribute to tumour cell migration and invasion among other things by inducing local volume changes and/or by modulating Ca 2+ and H + signalling. Targeting cell migration therapeutically bears great clinical potential, because it is a prerequisite for metastasis. Ion transport proteins appear to be attractive candidate target proteins for this purpose because they are easily accessible as membrane proteins and often overexpressed or activated in cancer. Importantly, a number of clinically widely used drugs are available whose anticipated efficacy as anti-tumour drugs, however, has now only begun to be evaluated.

Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters

2004 ◽  
Vol 5 (4) ◽  
pp. 254-258 ◽  
Author(s):  
Frank Entschladen ◽  
Theodore L Drell ◽  
Kerstin Lang ◽  
Jan Joseph ◽  
Kurt S Zaenker
Keyword(s):  
Cell Migration ◽  
Tumour Cell ◽  
Invasion And Metastasis

scholarly journals The E3 Ubiquitin Ligase RBCK1 Promotes The Invasion and Metastasis of Hepatocellular Carcinoma By Destroying The PPARγ/PGC1α Complex

2021 ◽  
Author(s):  
Zheng Xu ◽  
Jun Shao ◽  
Wenming Zhang ◽  
Xiuxia Liu ◽  
Shouhua Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Migration ◽  
Tumour Cell ◽  
Aerobic Glycolysis ◽  
Cell Metabolism ◽  
Tumour Microenvironment ◽  
Migration And Invasion ◽  
Tumour Metastasis ◽  
Inhibit Tumour Metastasis ◽  
Hcc Cells

Abstract Background: The disruption of tumour cell metabolism can inhibit tumour metastasis, indicating that aerobic glycolysis is central to tumour development. However, the key factors responsible for mediating aerobic glycolysis in hepatocellular carcinoma (HCC) remain unknown. Methods: This study investigated the function and clinical significance of RBCK1 protein expression in HCC. We analyzed RBCK1 expression from the TCGA-LIHC dataset and surgical specimens of 216 HCC patients. The correlation between the clinical characteristics and prognosis was also determined. Furthermore, over-expression and knockdown experiments of RBCK1 were developed to explore their effects on HCC cell migration, invasion and aerobic glycolysis. Moreover, a molecular mechanism of RBCK1 promotes HCC metastasis was explored.Results: Here, we observed that RBCK1 expression was significantly upregulated in HCC tissues. Our clinical study showed that high RBCK1 expression significantly correlated with poor tumour survival and distant invasion. Functional assays using HCC cells revealed that RBCK1 promoted migration and invasion by enhancing the Warburg effect, and that GLUT1 was critical for RBCK1-mediated aerobic glycolysis. Furthermore, RBCK1-mediated regulation of WNT/β-catenin/GLUT1 pathway-induced HCC cell migration and aerobic glycolysis was dependent on the destruction of the PPARγ/PGC1α complex. Mechanistically, RBCK1 promoted PPARγ ubiquitination and degradation, causing RBCK1 overexpression to enhance the transcriptional activity of WNT/β-catenin. This consequently upregulated the expression of GLUT1-mediated aerobic glycolysis in HCC cells, promoting tumour cell metastasis and invasion.Conclusion: Altogether, our findings identify a mechanism used by HCC cells to survive the nutrient-poor tumour microenvironment and also provide insight into the role of RBCK1 in HCC cell adaptation to metabolic stresses.

EGFR signalling promotes tumour cell migration in adamantinomatous craniopharyngiomas

2010 ◽  
Vol 118 (08) ◽  
Author(s):  
A Hölsken ◽  
M Buchfelder ◽  
R Fahlbusch ◽  
I Blümcke ◽  
R Buslei
Keyword(s):  
Cell Migration ◽  
Tumour Cell
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