A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes

Nature ◽  
1987 ◽  
Vol 325 (6101) ◽  
pp. 268-272 ◽  
Author(s):  
Dirk Bohmann ◽  
Walter Keller ◽  
Trevor Dale ◽  
Hans R. Schöler ◽  
Graham Tebb ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
U2 Snrna

The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22

Genomics ◽  
1991 ◽  
Vol 11 (2) ◽  
pp. 374-378 ◽  
Author(s):  
Paula S. Henthorn ◽  
Christine C. Stewart ◽  
Tom Kadesch ◽  
Jennifer M. Puck
Keyword(s):  
Transcription Factor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Gene Encoding

scholarly journals Activation of Tripartite Motif Containing 63 Expression by Transcription Factor EB and Transcription Factor Binding to Immunoglobulin Heavy Chain Enhancer 3 Is Regulated by Protein Kinase D and Class IIa Histone Deacetylases

2021 ◽  
Vol 11 ◽  
Author(s):  
Cristina Pablo Tortola ◽  
Britta Fielitz ◽  
Yi Li ◽  
Julia Rüdebusch ◽  
Friedrich C. Luft ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Kinase ◽  
Heavy Chain ◽  
Nuclear Export ◽  
Immunoglobulin Heavy Chain ◽  
Inhibitory Effect ◽  
Physical Interaction ◽  
Tripartite Motif ◽  
Transcription Factor Eb ◽  
Class Iia Hdacs

RationaleThe ubiquitin–proteasome system (UPS) is responsible for skeletal muscle atrophy. We showed earlier that the transcription factor EB (TFEB) plays a role by increasing E3 ubiquitin ligase muscle really interesting new gene-finger 1(MuRF1)/tripartite motif-containing 63 (TRIM63) expression. MuRF 1 ubiquitinates structural proteins and mediates their UPS-dependent degradation. We now investigated how TFEB-mediated TRIM63 expression is regulated.ObjectiveBecause protein kinase D1 (PKD1), histone deacetylase 5 (HDAC5), and TFEB belong to respective families with close structural, regulatory, and functional properties, we hypothesized that these families comprise a network regulating TRIM63 expression.Methods and ResultsWe found that TFEB and transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3) activate TRIM63 expression. The class IIa HDACs HDAC4, HDAC5, and HDAC7 inhibited this activity. Furthermore, we could map the HDAC5 and TFE3 physical interaction. PKD1, PKD2, and PKD3 reversed the inhibitory effect of all tested class IIa HDACs toward TFEB and TFE3. PKD1 mediated nuclear export of all HDACs and lifted TFEB and TFE3 repression. We also mapped the PKD2 and HDAC5 interaction. We found that the inhibitory effect of PKD1 and PKD2 toward HDAC4, HDAC5, and HDAC7 was mediated by their phosphorylation and 14-3-3 mediated nuclear export.ConclusionTFEB and TFE3 activate TRIM63 expression. Both transcription factors are controlled by HDAC4, HDAC5, HDAC7, and all PKD-family members. We propose that the multilevel PKD/HDAC/TFEB/TFE3 network tightly controls TRIM63 expression.

Regulation of interleukin 7–dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5

2005 ◽  
Vol 6 (8) ◽  
pp. 836-843 ◽  
Author(s):  
Eric Bertolino ◽  
Karen Reddy ◽  
Kay L Medina ◽  
Evan Parganas ◽  
James Ihle ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Gene Rearrangements ◽  
Interleukin 7 ◽  
Variable Gene
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