A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells

Nature ◽  
1986 ◽  
Vol 320 (6058) ◽  
pp. 168-170 ◽  
Author(s):  
Kurt G. Beam ◽  
C. Michael Knudson ◽  
Jeanne A. Powell
Keyword(s):  
Skeletal Muscle ◽  
Calcium Current ◽  
Muscle Cells ◽  
Lethal Mutation ◽  
Skeletal Muscle Cells

A third type of calcium current in cultured human skeletal muscle cells

1992 ◽  
Vol 138 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Michèle Rivet ◽  
Christian Cognard ◽  
Nathalie Imbert ◽  
Yves Rideau ◽  
Gérard Duport ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Calcium Current ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells

Role of Calcium Currents in E-C Coupling and Evolution of the T-System and SR in Developing Cultured Embryonic Amphibian Skeletal Muscle Cells

2000 ◽  
Vol 6 (S2) ◽  
pp. 92-93
Author(s):  
Gonzalez-Serratos H ◽  
Cordoba-Rodriguez R ◽  
Matteson D.R. ◽  
Rozycka M.
Keyword(s):  
Skeletal Muscle ◽  
Calcium Current ◽  
Muscle Cells ◽  
Calcium Currents ◽  
Skeletal Muscle Cells ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels ◽  
Slow Inward Calcium Current ◽  
T System

Adult frog phasic skeletal muscle cells have slow inward calcium current (ICa) (Stanfield, 1977) carried through L-type voltage dependent calcium channels. It has been suggested that ICa may play a role in E-C coupling (Cota & Stefani, 1981, 1989). However, phasic skeletal muscle cells contract for several minutes after the extracellular Ca2+ concentration ([Ca2+]o) is lowered to <10-8 M (Armstrong et al, 1972). Therefore, extracellular Ca2+ (Ca2+o) is not essential for contraction in these fibers. It has been also shown, by blocking Ica that Ica is not essential for triggering contraction (Gonzalez-Serratos et al., 1982). These results have led to the conclusion that Ica has no obvious role in E-C coupling in adult amphibian phasic skeletal muscle. The question arises then as to what is the biological role Ica in phasic skeletal muscle? We have observed that embryonic skeletal muscle cells are capable of contracting during the first day of development in culture (Cordoba-Rodriguez, et al., 1996), before the T-system and the sarcoplasmic reticulum (SR)may have fully developed (Flucher, et al., 1993).

Extracts of Hymenocardia acida ameliorate insulin resistance in skeletal muscle cells

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
II Ezeigbo ◽  
C Wheeler-Jones ◽  
S Gibbons ◽  
ME Cleasby
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Ameliorate Insulin Resistance

TGFß regulates metabolism of human skeletal muscle cells by miRNAs

2018 ◽  
Author(s):  
S Höckele ◽  
P Huypens ◽  
C Hoffmann ◽  
T Jeske ◽  
M Hastreiter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells
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