Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth

Nature ◽  
1985 ◽  
Vol 315 (6018) ◽  
pp. 413-416 ◽  
Author(s):  
Robert E. Hammer ◽  
Ralph L. Brinster ◽  
Michael G. Rosenfeld ◽  
Ronald M. Evans ◽  
Kelly E. Mayo
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Human Growth Hormone ◽  
Somatic Growth ◽  
Human Growth ◽  
Growth Hormone Releasing Factor

scholarly journals Dramatic Pituitary Hyperplasia in Transgenic Mice Expressing a Human Growth Hormone-Releasing Factor Gene

1988 ◽  
Vol 2 (7) ◽  
pp. 606-612 ◽  
Author(s):  
Kelly E. Mayo ◽  
Robert E. Hammer ◽  
Larry W. Swansont ◽  
Ralph L. Brinster ◽  
Michael G. Rosenfeld ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Growth Hormone Releasing Factor ◽  
Factor Gene ◽  
Pituitary Hyperplasia

Periodic interactions of GH-releasing factor and somatostatin can augment GH release in vitro

1987 ◽  
Vol 253 (5) ◽  
pp. E508-E514
Author(s):  
J. Weiss ◽  
M. J. Cronin ◽  
M. O. Thorner
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Male Rat ◽  
Base Line ◽  
Additive Effects ◽  
Growth Hormone Releasing Factor ◽  
The Impact

Growth hormone (GH) is secreted as pulses in vivo. To understand the signals governing this periodicity, we have established a perifusion-based model of pulsatile GH release. Male rat anterior pituitaries were dispersed and perifused with pulses of human growth hormone-releasing factor-(1--40) (GHRF), with or without a continuous or discontinuous somatostatin tonus. An experiment was composed of a 1-h base-line collection followed by four 3-h cycles; each contained single or paired 10-min infusion(s) of 3 nM GHRF. In testing the impact of somatostatin, the protocol was identical except that 0.3 nM somatostatin was added 30 min into the base-line period and then was either continued throughout the study or withdrawn during the periods of GHRF infusion. GH base lines with somatostatin were lower than vehicle base lines (P less than 0.05). GHRF pulses generated consistent peaks of GH release between 200 and 300 ng. min-1. (10(7) cells)-1, and these peaks were not altered by continuous somatostatin. In contrast, withdrawal of somatostatin during GHRF administration elicited markedly higher GH peaks (P less than 0.05) and more total GH release (P less than 0.05). This response could not be accounted for by the additive effects of GHRF and somatostatin withdrawal.

Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice.

1986 ◽  
Vol 5 (8) ◽  
pp. 1877-1883 ◽  
Author(s):  
D. Morello ◽  
G. Moore ◽  
A.M. Salmon ◽  
M. Yaniv ◽  
C. Babinet
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Human Growth Hormone ◽  
Fusion Gene ◽  
Human Growth
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