Gene rearrangement in cells with natural killer activity and expression of the β-chain of the T-cell antigen receptor

Nature ◽  
1985 ◽  
Vol 314 (6012) ◽  
pp. 631-633 ◽  
Author(s):  
Y. Yanagi ◽  
N. Caccia ◽  
M. Kronenberg ◽  
B. Chin ◽  
J. Roder ◽  
...  
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Gene Rearrangement ◽  
Antigen Receptor ◽  
Natural Killer Activity ◽  
T Cell Antigen Receptor ◽  
Killer Activity ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Β Chain

Complexity of human T-cell antigen receptor β-chain constant- and variable-region genes

Nature ◽  
1984 ◽  
Vol 312 (5994) ◽  
pp. 541-545 ◽  
Author(s):  
J. E. Sims ◽  
A. Tunnacliffe ◽  
W. J. Smith ◽  
T. H. Rabbitts
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
Variable Region ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Human T Cell ◽  
Variable Region Genes ◽  
Β Chain

Retroviral transduction of T-cell antigen receptor β-chain and myc genes

Nature ◽  
1987 ◽  
Vol 326 (6109) ◽  
pp. 190-194 ◽  
Author(s):  
Ruth Fulton ◽  
Douglas Forrest ◽  
Robert McFarlane ◽  
David Onions ◽  
James C. Neil
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Retroviral Transduction ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Β Chain

scholarly journals Rearrangements of T-cell antigen receptor delta chain gene in hematologic neoplasms

Blood ◽  
1989 ◽  
Vol 74 (8) ◽  
pp. 2707-2712 ◽  
Author(s):  
N Asou ◽  
T Hattori ◽  
M Matsuoka ◽  
F Kawano ◽  
K Takatsuki
Keyword(s):  
T Cell ◽  
B Cell ◽  
Gene Rearrangement ◽  
Antigen Receptor ◽  
Chain Gene ◽  
Gene Rearrangements ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Delta Gene

Abstract Rearrangements of the T-cell antigen receptor (TCR) delta chain gene were studied in primary neoplastic cells from 137 patients with leukemia or lymphoma. TCR delta gene rearrangements or deletions were observed in all 50 T-cell neoplasms: 5 of 8 CD3- T-cell neoplasms showed rearrangements, whereas biallelic deletion of TCR delta gene was the most common pattern in CD3+ T-cell neoplasm (39 of 42 patients). Rearrangements of TCR delta gene were also detected in 23 of 40 immature B-cell leukemias, including 22 of 25 patients with rearrangements of TCR gamma gene, 2 of 17 mature B-cell neoplasms, and 3 of 30 myeloid leukemias. Thus, TCR delta gene rearrangement or deletion is always found in T-cell neoplasms and is frequently found in immature B-cell leukemias associated with TCR gamma gene rearrangement. Furthermore, TCR delta gene rearrangements associated with the germline configuration of the TCR beta, gamma, and immunoglobulin heavy chain genes were observed in two immature T-cell leukemias, suggesting that TCR delta gene rearrangements precede TCR gamma and beta gene rearrangements. These results indicate that an analysis of TCR delta gene rearrangement provides potential tools to establish the clonality of immature T-cell neoplasms and to identify the normal stages of lymphocyte differentiation.

scholarly journals T cell antigen receptor gene rearrangement in refractory anemia with excess of blasts(RAEB).

1988 ◽  
Vol 77 (8) ◽  
pp. 1246-1250
Author(s):  
Kazuaki YAMAOKA ◽  
Yoshitaka AOYAGI ◽  
Hajime AKIMOTO ◽  
Masaaki KANAYAMA ◽  
Hisamaru HIRAI ◽  
...  
Keyword(s):  
T Cell ◽  
Gene Rearrangement ◽  
Receptor Gene ◽  
Antigen Receptor ◽  
Refractory Anemia ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen

Structure and diversity of the T-cell antigen receptor β chain in a teleost fish

1995 ◽  
Vol 84 (1-2) ◽  
pp. 116-116 ◽  
Author(s):  
Sylvie Partula ◽  
Arnaud Guerra ◽  
Julien S Fellah ◽  
Jacques Charlemagne
Keyword(s):  
T Cell ◽  
Teleost Fish ◽  
Antigen Receptor ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Β Chain

Crystallization and Preliminary X-ray Diffraction Analysis of the β-Chain of a T-cell Antigen Receptor

1994 ◽  
Vol 235 (2) ◽  
pp. 795-797 ◽  
Author(s):  
Ginette Boulot ◽  
Graham A. Bentley ◽  
Klaus Karjalainen ◽  
Roy A. Mariuzza
Keyword(s):  
T Cell ◽  
Diffraction Analysis ◽  
Antigen Receptor ◽  
X Ray Diffraction ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
X Ray ◽  
Cell Antigen ◽  
Β Chain

The methylation state of the T cell antigen receptor β chain gene in subpopulations of mouse thymocytes

1989 ◽  
Vol 19 (5) ◽  
pp. 873-879 ◽  
Author(s):  
Shigeru Sakamoto ◽  
Bonnie J. Mathieson ◽  
Kristin L. Komschlies ◽  
Narayan K. Bhat ◽  
Howard A. Young
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
Chain Gene ◽  
T Cell Antigen Receptor ◽  
Methylation State ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Β Chain
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