Virology: Tissue-specific transformation by human T-cell leukaemia virus

Nature ◽  
1984 ◽  
Vol 310 (5975) ◽  
pp. 273-274 ◽  
Author(s):  
Robin Weiss
Keyword(s):  
T Cell ◽  
Cell Leukaemia ◽  
Leukaemia Virus ◽  
Tissue Specific ◽  
Human T Cell

scholarly journals Calcium-mediated inhibition of phorbol ester and Tax trans-activation of the human T cell leukaemia virus type 1

1994 ◽  
Vol 75 (7) ◽  
pp. 1623-1631 ◽  
Author(s):  
K. F. T. Copeland ◽  
A. G. M. Haaksma ◽  
J. Goudsmit ◽  
J. L. Heeney
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Phorbol Ester ◽  
Cell Leukaemia ◽  
Leukaemia Virus ◽  
Human T Cell

scholarly journals No real homology of human T-cell leukaemia virus envelope with class I HLA

Nature ◽  
1984 ◽  
Vol 308 (5954) ◽  
pp. 85-85 ◽  
Author(s):  
M. F. CLARKE ◽  
E. P. GELMANN ◽  
M. S. REITZ
Keyword(s):  
T Cell ◽  
Class I ◽  
Cell Leukaemia ◽  
Virus Envelope ◽  
Leukaemia Virus ◽  
Human T Cell

Protective effect of interferon ? on human T cell leukaemia virus type I infection of CD4+ T cells isolated from human cord blood

1993 ◽  
Vol 37 (2) ◽  
pp. 97-104 ◽  
Author(s):  
Beatrice Macchi ◽  
Isabella Faraoni ◽  
Antonio Mastino ◽  
Chiara D'Onofrio ◽  
Gianna Romeo ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Protective Effect ◽  
Cord Blood ◽  
Virus Type ◽  
Cell Leukaemia ◽  
Type I ◽  
Human Cord Blood ◽  
Leukaemia Virus ◽  
Human T Cell

AB0268 HUMAN T-CELL LEUKAEMIA VIRUS TYPE 1 MAY INVALIDATE T-SPOT.TB RESULTS AMONG RHEUMATOID ARTHRITIS PATIENTS: A RETROSPECTIVE OBSERVATIONAL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1432.1-1433
Author(s):  
K. Umekita ◽  
Y. Hashiba ◽  
R. Kudou ◽  
S. Miyauchi ◽  
M. Kimura ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Virus Type ◽  
Peripheral Blood ◽  
Medical Records ◽  
Cell Leukaemia ◽  
Leukaemia Virus ◽  
Human T Cell ◽  
Ifn Γ

Background:In clinical rheumatology, interferon-γ release assays (IGRAs) have been reported as a useful diagnostic test for latent tuberculosis infection (LTBI) before beginning the administration of biologics such as anti-TNF therapies (1). CD4-positive T cells are the main target in Human T-cell leukaemia virus type 1 (HTLV-1) infection. Several reports suggest that the reaction of tuberculin skin test (TST) is attenuated in HTLV-1-positive individuals compared with that in HTLV-1-negative individuals (2). However, it remains unclear whether IGRAs are reliable for detecting TB infection among HTLV-1-positive RA patients.Objectives:The present study aimed to investigate the usefulness of the T-SPOT.TBassay in HTLV-1-positive RA patients. In addition, the association between the existence of IFN-γ producing T cells and HTLV-1 proviral loads (PVLs) in HTLV-1-positive RA patients was analysed on the basis of the T-SPOT.TBassay results.Methods:We reviewed the medical records of 75 HTLV-1-negative and 29 HTLV-1-positive RA patients were suspected cases of LTBI and evaluated using the T-SPOT.TBassay as a clinical practice from April 2012 to July 2019. The results of T-SPOT.TBwere collected from medical records, retrospectively. Peripheral blood samples were obtained from HTLV-1-positive RA patients for the analysis of HTLV-1 PVLs values. The study protocol was approved by the research ethics committees of our hospitals.Results:Approximately 55% of the HTLV-1-positive RA patients showed invalid results for the T-SPOT.TBassay (p < 0.0001); the cause of invalid results was a spot-forming count of >10 spots in the negative controls of the T-SPOT.TBassay among HTLV-1-positive RA patients. Among HTLV-1-positive RA patients, HTLV-1 PVL values were significantly higher in 16 patients who showed invalid results than in 13 patients who did not (p = 0.003). There were no between-group differences in female patient ratio, age, RA disease activity and therapeutic regimens. IFN-γ producing cells were detected in the peripheral blood of HTLV-1-positive RA patients without stimulation with TB-specific antigens.Conclusion:The incidence of invalid results for the T-SPOT.TBassay has been reported to be as low as 0.6% (3). The results of this assay for screening of LTBI in HTLV-1-positive RA patients should be interpreted with caution. Furthermore, our results show that an increase in IFN-γ producing T cell numbers due to HTLV-1 infection in RA patients may affect the pathogenesis of RA.References:[1]Iannone, F., et al.J. Rheumatol. Suppl.91, 41-46 (2014).[2]Tachibana, N., et al.Int. J. Cancer42, 829-831 (1988).[3]Rego, K., et al.Tuberculosis (Edinb.)108, 178-185 (2018).Acknowledgments:We would like to thank Dr Yuki Hashikura and Ms Yuki Kaseda of the University of Miyazaki for their technical support in this work. We would also like to acknowledge Ms Yumiko Kai at the Institute of Rheumatology, Zenjinkai Shimin-no-Mori Hospital, for her help in data management.A part this work was supported by a grant from the Practical Research Project for Rare/Intractable Diseases of the Japan Agency for Medical Research and Development (Grant No. JP19ek0109356), a Health and Labor Sciences Research Grant on Rare and Intractable Diseases from the Ministry of Health, Labor and Welfare of Japan (Grant No. 19FC1007), and a Grant-in-Aid for Clinical Research from Miyazaki University Hospital.Disclosure of Interests:Kunihiko Umekita Paid instructor for: Astellas Pharma Inc. Chugai Pharma Inc. Tanabe-Mitsubishi Pharma Inc., Speakers bureau: Bristol-Myers Squibb, Yayoi Hashiba: None declared, Risa Kudou: None declared, Shunichi Miyauchi: None declared, Masatoshi Kimura: None declared, Motohiro Matsuda: None declared, Chihiro Iwao: None declared, Yumi Kariya: None declared, Takeshi Kawaguchi: None declared, Katoko Takajo: None declared, Koushou Iwao: None declared, Yuuki Rikitake: None declared, Ichiro Takajo: None declared, Toshihiko Hidaka Paid instructor for: Astellas Pharma Inc. Chugai Pharma Inc. Tanabe-Mitsubishi Pharma Inc., Speakers bureau: Astellas Pharma Inc. Chugai Pharma Inc. Tanabe-Mitsubishi Pharma Inc., Akihiko Okayama: None declared

6 Human T-cell leukaemia virus

1995 ◽  
Vol 8 (1) ◽  
pp. 131-148 ◽  
Author(s):  
Genoveffa Franchini ◽  
Howard Streicher
Keyword(s):  
T Cell ◽  
Cell Leukaemia ◽  
Leukaemia Virus ◽  
Human T Cell

NEGATIVE ASSOCIATION BETWEEN THE HUMAN T-CELL LEUKAEMIA VIRUS TYPE I AND LARGE GRANULAR LYMPHOCYTE LEUKAEMIA IN JAPAN

The Lancet ◽  
1988 ◽  
Vol 332 (8617) ◽  
pp. 962 ◽  
Author(s):  
Nobutaka Imamura ◽  
Atsushi Kuramoto ◽  
Keisei Kawa-Ha ◽  
Hiroshi Fujii ◽  
Tomoo Takiguchi
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Negative Association ◽  
Large Granular Lymphocyte ◽  
Cell Leukaemia ◽  
Type I ◽  
Leukaemia Virus ◽  
Human T Cell ◽  
Large Granular Lymphocyte Leukaemia

scholarly journals Prevalence of Human T Cell Leukaemia Virus amongst Blood Donors

2009 ◽  
Vol 65 (1) ◽  
pp. 38-40 ◽  
Author(s):  
CN Chaudhari ◽  
T Shah ◽  
RN Misra
Keyword(s):  
T Cell ◽  
Blood Donors ◽  
Cell Leukaemia ◽  
Leukaemia Virus ◽  
Human T Cell
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