Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma

Nature ◽  
1984 ◽  
Vol 309 (5969) ◽  
pp. 592-597 ◽  
Author(s):  
T. H. Rabbitts ◽  
A. Forster ◽  
P. Hamlyn ◽  
R. Baer
Keyword(s):  
Somatic Mutation ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma

V H Gene Analysis in Sporadic Burkitt's Lymphoma: Somatic Mutation and Intraclonal Diversity with Special Reference to the Tumor Cells Involving Germinal Center

2002 ◽  
Vol 43 (1) ◽  
pp. 159-164 ◽  
Author(s):  
Kouichi Isobe ◽  
Jun-ichi Tamaru ◽  
Shigeo Nakamura ◽  
Kenichi Harigaya ◽  
Atsuo Mikata ◽  
...  
Keyword(s):  
Special Reference ◽  
Tumor Cells ◽  
Somatic Mutation ◽  
Germinal Center ◽  
Burkitt’S Lymphoma ◽  
Gene Analysis ◽  
Burkitt's Lymphoma ◽  
H Gene

Somatic mutation and transcriptional deregulation of myc in endemic Burkitt's lymphoma disease: heptamer-nonamer recognition mistakes?

1989 ◽  
Vol 9 (1) ◽  
pp. 74-82
Author(s):  
B Morse ◽  
V J South ◽  
P G Rothberg ◽  
S M Astrin
Keyword(s):  
Somatic Mutation ◽  
Sequence Data ◽  
Burkitt’S Lymphoma ◽  
Complete Sequence ◽  
Burkitt's Lymphoma ◽  
Recognition Sequence ◽  
Intron 1 ◽  
Exon 1 ◽  
Transcriptional Deregulation ◽  
Lymphoma Sample

We examined the structure and expression of the myc protooncogene in DNA extracted from a primary (uncultured) endemic Burkitt's lymphoma sample designated eBL3. Dot and Northern (RNA) blot analyses demonstrated extreme levels of myc RNA in the eBL3 sample. Nearly complete sequence data of the altered myc locus isolated from eBL3 DNA demonstrated extensive mutations (duplications, insertions, and deletions) in critical myc regulatory regions. Taken together, the data support the idea that myc transcriptional deregulation in Burkitt's lymphoma disease may be a consequence of the position and number of mutations produced within and around the myc locus. Furthermore, the myc exon-1-intron-1 hypermutable PvuII site is part of a potential heptamer-nonamer recognition sequence, suggesting a mechanism for mutation in endemic Burkitt's lymphoma disease.

scholarly journals Somatic mutation and transcriptional deregulation of myc in endemic Burkitt's lymphoma disease: heptamer-nonamer recognition mistakes?

1989 ◽  
Vol 9 (1) ◽  
pp. 74-82 ◽  
Author(s):  
B Morse ◽  
V J South ◽  
P G Rothberg ◽  
S M Astrin
Keyword(s):  
Somatic Mutation ◽  
Sequence Data ◽  
Burkitt’S Lymphoma ◽  
Complete Sequence ◽  
Burkitt's Lymphoma ◽  
Recognition Sequence ◽  
Intron 1 ◽  
Exon 1 ◽  
Transcriptional Deregulation ◽  
Lymphoma Sample

We examined the structure and expression of the myc protooncogene in DNA extracted from a primary (uncultured) endemic Burkitt's lymphoma sample designated eBL3. Dot and Northern (RNA) blot analyses demonstrated extreme levels of myc RNA in the eBL3 sample. Nearly complete sequence data of the altered myc locus isolated from eBL3 DNA demonstrated extensive mutations (duplications, insertions, and deletions) in critical myc regulatory regions. Taken together, the data support the idea that myc transcriptional deregulation in Burkitt's lymphoma disease may be a consequence of the position and number of mutations produced within and around the myc locus. Furthermore, the myc exon-1-intron-1 hypermutable PvuII site is part of a potential heptamer-nonamer recognition sequence, suggesting a mechanism for mutation in endemic Burkitt's lymphoma disease.

Burkitt's lymphoma in an arid part of Texas

JAMA ◽  
1966 ◽  
Vol 198 (10) ◽  
pp. 1124-1125 ◽  
Author(s):  
J. J. Twomey
Keyword(s):  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma

Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt's Lymphoma

2018 ◽  
Vol 14 (2) ◽  
Author(s):  
Andrew J. Byrne ◽  
Sandra A. Bright ◽  
Darren Fayne ◽  
James P. McKeown ◽  
Thomas McCabe ◽  
...  
Keyword(s):  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Apoptotic Effects ◽  
Related Compounds
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