Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

Nature ◽  
1984 ◽  
Vol 309 (5966) ◽  
pp. 356-358 ◽  
Author(s):  
F. Mokhtarian ◽  
D. E. McFarlin ◽  
C. S. Raine
Keyword(s):  
T Cells ◽  
Myelin Basic Protein ◽  
Adoptive Transfer ◽  
Basic Protein ◽  
Demyelinating Disease

scholarly journals Surface Layer Protein A Expressed in Clostridioides difficile DJNS06-36 Possesses an Encephalitogenic Mimotope of Myelin Basic Protein

2020 ◽  
Vol 9 (1) ◽  
pp. 34
Author(s):  
John E. Mindur ◽  
Sudhir K. Yadav ◽  
Naoko Ito ◽  
Mitsutoshi Senoh ◽  
Haru Kato ◽  
...  
Keyword(s):  
T Cells ◽  
Surface Layer ◽  
Amino Acid ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Demyelinating Disease ◽  
Protein A ◽  
Enteric Bacteria ◽  
Surface Layer Protein ◽  
Clostridioides Difficile

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Recent studies suggest that migration of Th1 and Th17 cells specific for enteric bacteria from the gut to the CNS may lead to the initiation and/or exacerbation of autoimmune diseases including MS. Human leukocyte antigen (HLA)-DR15 is an MHC class II (MHCII) haplotype highly associated with the development of MS that contains the two HLA-DRB* genes, DRB1*1501 (DR2b) and DRB5*0101 (DR2a). To identify enteric bacteria which harbor antigenic epitopes that activate myelin-specific T cells and drive CNS inflammation, we screened for enteric bacteria which express cross-reactive epitopes (‘mimotopes’) of an immunodominant myelin basic protein 89–98 (MBP89-98) epitope. Based on known MHCII HLA-DR2a amino acid binding motifs and cultivation with splenic T cells isolated from MBP-T cell receptor (TCR)/DR2a transgenic (Tg) mice, we discovered that a certain variant of surface layer protein A (SLPA), which is expressed by a subtype of Clostridioides difficile, contains an amino acid sequence that activates MBP89-98-reactive T cells. Furthermore, activation of MBP-specific T cells by SLPA upon active immunization induced experimental autoimmune encephalomyelitis (EAE) in MBP-TCR/DR2a Tg mice. This study suggests that a unique strain of C. difficile possesses an encephalitogenic mimotope of MBP that activates autoreactive, myelin-specific T cells.

scholarly journals Tolerance Induction and Autoimmune Encephalomyelitis Amelioration After Administration of Myelin Basic Protein–derived Peptide

1997 ◽  
Vol 186 (4) ◽  
pp. 507-515 ◽  
Author(s):  
Suzana Marusic ◽  
Susumu Tonegawa
Keyword(s):  
T Cells ◽  
Myelin Basic Protein ◽  
Intraperitoneal Injection ◽  
Basic Protein ◽  
Demyelinating Disease ◽  
Critical Role ◽  
Tolerance Induction ◽  
Autoimmune Encephalomyelitis ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant

Experimental autoimmune encephalomyelitis (EAE), a demyelinating disease of the central nervous system, is an animal model of paralyzing human disease, multiple sclerosis. EAE is readily induced by immunization with myelin basic protein (MBP) in mice transgenic for an αβ T cell receptor (TCR) that is specific for MBP. Subcutaneous injection of p17 (a peptide consisting of 17 NH2-terminal aminoacids of MBP) in complete Freund's adjuvant (CFA) causes paralysis. Induction of paralysis is inhibited by prior intraperitoneal injection of the same peptide in incomplete Freund's adjuvant (IFA). In addition, ongoing paralysis is ameliorated by subsequent intraperitoneal injection of p17 in IFA. Tolerance induction is equally efficient in Fas-deficient and IL-4–deficient TCR-transgenic mice, suggesting that neither activation-induced cell death nor differentiation into Th2 type cells plays a role in the tolerance induction. Tolerance induction by p17 seems to be based on reduction in the responsiveness of anti-MBP T cells, as documented by lower overall antigen-induced lymphokine production and proliferation, as well as diminished upregulation of early activation marker CD69 by tolerized T cells. We propose that continuous encounters of MBP-specific T cells with p17 play a critical role in the induction and maintenance of tolerance.

Lewis Rat T Cells Can Reutilize, Process, and Present Myelin Basic Protein to Antigen-Specific T Cell Lines

1994 ◽  
Vol 156 (1) ◽  
pp. 36-53 ◽  
Author(s):  
Joanne M. St. Louis ◽  
John M. Pasick ◽  
Colleen Stein ◽  
David Freeman ◽  
Bhagirath Singh ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
Lewis Rat ◽  
T Cell Lines

The affinity spectrum of myelin basic protein-reactive T cells

1999 ◽  
pp. 3-9
Author(s):  
B. Mazzanti ◽  
E. Traggiai ◽  
B. Hemmer ◽  
R. Martin ◽  
L. Massacesi ◽  
...  
Keyword(s):  
T Cells ◽  
Myelin Basic Protein ◽  
Basic Protein

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 ◽  
Vol 22 (4) ◽  
pp. 1083-1087 ◽  
Author(s):  
Tomas Olsson ◽  
Jiabin Sun ◽  
Jan Hillert ◽  
Bo Höjeberg ◽  
Hans-Peter Ekre ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Myelin Basic Protein ◽  
Basic Protein

Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis

1998 ◽  
Vol 91 (1-2) ◽  
pp. 19-27 ◽  
Author(s):  
Annette Pohl-Koppe ◽  
Sandra K. Burchett ◽  
Elizabeth A. Thiele ◽  
David A. Hafler
Keyword(s):  
T Cells ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Acute Disseminated Encephalomyelitis
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