Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

Nature ◽  
1983 ◽  
Vol 305 (5937) ◽  
pp. 771-775 ◽  
Author(s):  
P. I. Schrier ◽  
R. Bernards ◽  
R. T. M. J. Vaessen ◽  
A. Houweling ◽  
A. J. van der Eb
1985 ◽  
Vol 5 (10-11) ◽  
pp. 1007-1014 ◽  
Author(s):  
Kathryn J. Wood ◽  
Peter J. Morris

The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used ’ fully vascularized heterotopic Cardiac altografts in the mouse and fully vascularized orthotopic renal allografts in the rat. Preparations of ceils expressing Class I MHC antigens, for example highly purified preparations of rat erythrocytes or platelets or mouse L cells (H2k) transfected with the D locus Class I gene of the b haplotype, LDb-1 cells, were used to pretreat recipients prior to transplantation, The function of the allograft was monitored in order to assess any beneficial effects induced by Class I MHC antigens. The results obtained implicate Class I MHC as important in the induction of specific immunosuppression of vascularized allograft rejection.


Cell ◽  
1988 ◽  
Vol 54 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Marie-Luise Blue ◽  
Kimberly A. Craig ◽  
Paul Anderson ◽  
Kenneth R. Branton ◽  
Stuart F. Schlossman

1986 ◽  
Vol 42 (2) ◽  
pp. 178-183 ◽  
Author(s):  
Rob M. W. de Wall ◽  
M. José J. T. Bogman ◽  
Ine M. H. A. Cornelissen ◽  
Arno N. Vermeulen ◽  
Robert A. P. Koene

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