scholarly journals Defective translation of measles virus matrix protein in a subacute sclerosing panencephalitis cell line

Nature ◽  
1983 ◽  
Vol 305 (5930) ◽  
pp. 153-155 ◽  
Author(s):  
Michael J. Carter ◽  
Margaret M. Willcocks ◽  
Volker ter Meulen
Keyword(s):  
Cell Line ◽  
Measles Virus ◽  
Matrix Protein ◽  
Subacute Sclerosing Panencephalitis

Measles virus matrix protein synthesized in a subacute sclerosing panencephalitis cell line

Science ◽  
1985 ◽  
Vol 228 (4704) ◽  
pp. 1219-1221 ◽  
Author(s):  
R. Sheppard ◽  
C. Raine ◽  
M. Bornstein ◽  
S. Udem
Keyword(s):  
Cell Line ◽  
Measles Virus ◽  
Matrix Protein ◽  
Subacute Sclerosing Panencephalitis

Subacute sclerosing panencephalitis: Measles virus matrix protein nucleic acid sequences detected by in situ hybridization

Neurology ◽  
1985 ◽  
Vol 35 (11) ◽  
pp. 1605-1605 ◽  
Author(s):  
P. Shapshak ◽  
W. W. Tourtellotte ◽  
S. Nakamura ◽  
M. C. Graves ◽  
M. Darvish ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Nucleic Acid ◽  
Measles Virus ◽  
Matrix Protein ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein Nucleic Acid ◽  
Nucleic Acid Sequences

Accumulated measles virus mutations in a case of subacute sclerosing panencephalitis: Interrupted matrix protein reading frame and transcription alteration

Virology ◽  
1986 ◽  
Vol 154 (1) ◽  
pp. 97-107 ◽  
Author(s):  
Roberto Cattaneo ◽  
Anita Schmid ◽  
Gabriela Rebmann ◽  
Knut Baczko ◽  
Volker Ter Meulen ◽  
...  
Keyword(s):  
Measles Virus ◽  
Matrix Protein ◽  
Subacute Sclerosing Panencephalitis ◽  
Reading Frame

scholarly journals Measles Virus Spreads in Rat Hippocampal Neurons by Cell-to-Cell Contact and in a Polarized Fashion

2002 ◽  
Vol 76 (11) ◽  
pp. 5720-5728 ◽  
Author(s):  
Markus U. Ehrengruber ◽  
Elisabeth Ehler ◽  
Martin A. Billeter ◽  
Hussein Y. Naim
Keyword(s):  
Hippocampal Neurons ◽  
Measles Virus ◽  
Matrix Protein ◽  
Fluorescent Protein ◽  
Subacute Sclerosing Panencephalitis ◽  
Hippocampal Slices ◽  
Pyramidal Cells ◽  
Cell Contact ◽  
F Protein ◽  
Green Fluorescent

ABSTRACT Measles virus (MV) can infect the central nervous system and, in rare cases, causes subacute sclerosing panencephalitis, characterized by a progressive degeneration of neurons. The route of MV transmission in neurons was investigated in cultured rat hippocampal slices by using MV expressing green fluorescent protein. MV infected hippocampal neurons and spread unidirectionally, in a retrograde manner, from CA1 to CA3 pyramidal cells and from there to the dentate gyrus. Spreading of infection depended on cell-to-cell contact and occurred without any detectable release of infectious particles. The role of the viral proteins in the retrograde MV transmission was determined by investigating their sorting in infected pyramidal cells. MV glycoproteins, the fusion protein (F) and hemagglutinin (H), the matrix protein (M), and the phosphoprotein (P), which is part of the viral ribonucleoprotein complex, were all sorted to the dendrites. While M, P, and H proteins remained more intracellular, the F protein localized to prominent, spine-type domains at the surface of infected cells. The detected localization of MV proteins suggests that local microfusion events may be mediated by the F protein at sites of synaptic contacts and is consistent with a mechanism of retrograde transmission of MV infection.

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