Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

Nature ◽  
1982 ◽  
Vol 299 (5882) ◽  
pp. 413-417 ◽  
Author(s):  
Steven A. Siegelbaum ◽  
Joseph S. Camardo ◽  
Eric R. Kandel
Keyword(s):  
Cyclic Amp ◽  
Sensory Neurones ◽  
K Channels

Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+channels of Aplysia sensory neurones in cell-free membrane patches

Nature ◽  
1985 ◽  
Vol 313 (6001) ◽  
pp. 392-395 ◽  
Author(s):  
M. J. Shuster ◽  
J. S. Camardo ◽  
S. A. Siegelbaum ◽  
E. R. Kandel
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Dependent Protein Kinase ◽  
Sensory Neurones ◽  
K Channels ◽  
Dependent Protein ◽  
Free Membrane

Capsaicin-Induced Ion Fluxes Increase Cyclic GMP but Not Cyclic AMP Levels in Rat Sensory Neurones in Culture

1989 ◽  
Vol 53 (4) ◽  
pp. 1203-1211 ◽  
Author(s):  
J. N. Wood ◽  
P. R. Coote ◽  
A. Minhas ◽  
I. Mullaney ◽  
M. McNeill ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Cyclic Gmp ◽  
Ion Fluxes ◽  
Sensory Neurones

Regulation of maxi-K+ channels on pancreatic duct cells by cyclic AMP-dependent phosphorylation

1990 ◽  
Vol 115 (3) ◽  
pp. 203-215 ◽  
Author(s):  
M. A. Gray ◽  
J. R. Greenwell ◽  
A. J. Garton ◽  
B. E. Argent
Keyword(s):  
Cyclic Amp ◽  
Pancreatic Duct ◽  
K Channels ◽  
Duct Cells ◽  
Pancreatic Duct Cells

Role of Ca 2+ -Dependent K + Channels in Cerebral Vasodilatation Induced by Increases in Cyclic GMP and Cyclic AMP in the Rat

Stroke ◽  
1996 ◽  
Vol 27 (9) ◽  
pp. 1603-1608 ◽  
Author(s):  
Roberto Paternò ◽  
Frank M. Faraci ◽  
Donald D. Heistad
Keyword(s):  
Cyclic Amp ◽  
Cyclic Gmp ◽  
K Channels ◽  
Cerebral Vasodilatation

scholarly journals Modulation of the serotonin-sensitive potassium channel in Aplysia sensory neurone cell body and growth cone

1986 ◽  
Vol 124 (1) ◽  
pp. 287-306
Author(s):  
S. A. Siegelbaum ◽  
F. Belardetti ◽  
J. S. Camardo ◽  
M. J. Shuster
Keyword(s):  
Cyclic Amp ◽  
Potassium Channel ◽  
Direct Evidence ◽  
Single Channel ◽  
Growth Cones ◽  
Single Channel Recording ◽  
Sensory Neurone ◽  
Sensory Neurones ◽  
Channel Modulation ◽  
Insight Into

Using single-channel recording, we have been able to obtain some insight into the molecular mechanism of a modulatory transmitter action in Aplysia sensory neurones. Our results show that serotonin produces a slow EPSP and increases action potential duration in the sensory neurones by producing prolonged closures of the S potassium channel. Such closures appear to be mediated by cyclic AMP-dependent phosphorylation of a membrane protein which may be the channel. Modulation of S channels by serotonin also occurs in sensory neurone growth cones. This provides the first direct evidence that channel modulation occurs in nerve processes and increases the likelihood of channel modulation at the nerve terminal.

Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy

Nature ◽  
10.1038/25367 ◽  
1998 ◽  
Vol 396 (6712) ◽  
pp. 687-690 ◽  
Author(s):  
Björn C. Schroeder ◽  
Christian Kubisch ◽  
Valentin Stein ◽  
Thomas J. Jentsch
Keyword(s):  
Cyclic Amp ◽  
Loss Of Function ◽  
K Channels
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