Fission-spectrum neutrons at reduced dose rates enhance neoplastic transformation

Nature ◽  
1982 ◽  
Vol 298 (5869) ◽  
pp. 67-69 ◽  
Author(s):  
C. K. Hill ◽  
F. M. Buonaguro ◽  
C. P. Myers ◽  
A. Han ◽  
M. M. Elkind
Keyword(s):  
Neoplastic Transformation ◽  
Dose Rates ◽  
Reduced Dose ◽  
Fission Spectrum

ON OPTIMAL CHEMOTHERAPY FOR HETEROGENEOUS TUMORS

2014 ◽  
Vol 22 (02) ◽  
pp. 177-197 ◽  
Author(s):  
URSZULA LEDZEWICZ ◽  
HEINZ SCHÄTTLER
Keyword(s):  
Medical Literature ◽  
Maximum Dose ◽  
Rest Period ◽  
Maximum Tolerated Dose ◽  
Therapeutic Agents ◽  
Tumor Burden ◽  
Singular Controls ◽  
Dose Rates ◽  
Reduced Dose ◽  
Heterogeneous Tumor

A mathematical model for cancer chemotherapy of heterogeneous tumor populations is considered as an optimal control problem with the objective to minimize the tumor burden over a prescribed therapy horizon. While an upfront maximum tolerated dose (MTD) regimen with rest-period has been confirmed as mathematically optimal for models when the tumor population is homogeneous, in the presence of partially sensitive or even resistant cells, protocols that administer the therapeutic agents at lower dose rates described by so-called singular controls become a viable alternative. In this paper, the structure of protocols that follow an initial upfront maximum dose treatment with reduced dose rate singular controls is investigated. Such protocols reflect structures which in the medical literature sometimes are called chemo-switch protocols.

Absence of a Dose-Fractionation Effect on Neoplastic Transformation Induced by Fission-Spectrum Neutrons in C3H 10T1/2 Cells

1991 ◽  
Vol 126 (3) ◽  
pp. 343 ◽  
Author(s):  
A. Saran ◽  
S. Pazzaglia ◽  
M. Coppola ◽  
S. Rebessi ◽  
V. Di Majo ◽  
...  
Keyword(s):  
Neoplastic Transformation ◽  
Dose Fractionation ◽  
Fission Spectrum ◽  
Fractionation Effect

DUAL-PARTICLE DOSEMETER BASED ON ORGANIC SCINTILLATOR

2020 ◽  
Vol 191 (3) ◽  
pp. 319-327
Author(s):  
C A Miller ◽  
A Di Fulvio ◽  
S D Clarke ◽  
S A Pozzi
Keyword(s):  
Scintillation Detector ◽  
New Method ◽  
Proof Of Concept ◽  
Dose Equivalent ◽  
Spectral Deconvolution ◽  
Dose Rates ◽  
Fission Spectrum ◽  
Photon Dose ◽  
Single Instrument ◽  
Better Than

Abstract Traditionally available handheld dosemeters are generally sensitive to only one type of radiation: neutrons or photons. Some dosemeters also rely on very specific attenuation correlations between response and dose, are not scalable in size and multiple dosemeters are required to characterise mixed-particle fields. The research presented here serves as a proof-of-concept for a method to simultaneously measure dose rates from neutrons and photons using a particle discriminating organic scintillation detector without the need for spectral deconvolution. The method was compared with traditional instruments and to simulation. Isotopic photon dose rates measured with this method were within 4% of simulated truth, whereas fission spectrum neutron dose rates were measured within 21%. Measurements of dose rates from both particles agree with simulated truth better than traditional instruments. This new method allows for measurement of dose equivalent from both neutrons and photons with a single instrument and no reliance on spectral deconvolution.

Neoplastic Transformation Is Enhanced by Multiple Low Doses of Fission-Spectrum Neutrons

1985 ◽  
Vol 102 (3) ◽  
pp. 404 ◽  
Author(s):  
C. K. Hill ◽  
B. A. Carnes ◽  
A. Han ◽  
M. M. Elkind
Keyword(s):  
Neoplastic Transformation ◽  
Low Doses ◽  
Fission Spectrum
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