scholarly journals Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

Nature ◽  
1982 ◽  
Vol 297 (5863) ◽  
pp. 205-208 ◽  
Author(s):  
N. Kitamura ◽  
A. Kitamura ◽  
K. Toyoshima ◽  
Y. Hirayama ◽  
M. Yoshida
Keyword(s):  
Gene Product ◽  
Genome Sequence ◽  
Rous Sarcoma Virus ◽  
Structural Similarity ◽  
Avian Sarcoma Virus ◽  
Rous Sarcoma ◽  
Sarcoma Virus ◽  
Avian Sarcoma ◽  
Transforming Gene

scholarly journals Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants.

1977 ◽  
Vol 146 (6) ◽  
pp. 1735-1747 ◽  
Author(s):  
H Hanafusa ◽  
C C Halpern ◽  
D L Buchhagen ◽  
S Kawai
Keyword(s):  
Rous Sarcoma Virus ◽  
Chicken Embryo ◽  
Genetic Interaction ◽  
Avian Sarcoma Virus ◽  
Rous Sarcoma ◽  
Src Gene ◽  
Sarcoma Virus ◽  
Avian Sarcoma ◽  
Chicken Embryo Fibroblasts

Transformation-defective (td) mutants of the Schmidt-Ruppin strain of Rous sarcoma virus (RSV), which contains deletions in the gene responsible for transformation (src gene), are unable to transform chicken embryo fibroblasts in vitro. Injection of some of these td mutants into newborn chickens resulted in the formation of sarcomas from which sarcoma virus was unfailingly recovered. The possibility that transforming RSV was present in the td virus preparations was excluded by further purification of the td viruses. Morphology of the foci induced by the newly recovered sarcoma virus was distinct from that of foci induced by the parental Schmidt Ruppin strain of RSV. It is suggested that the new sarcoma virus was generated as a result of the genetic interaction between the genomes of td virus and chicken cells.

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