scholarly journals Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation

Nature ◽  
1980 ◽  
Vol 286 (5773) ◽  
pp. 623-625 ◽  
Author(s):  
J. Jolles ◽  
H. Zwiers ◽  
C. J. van Dongen ◽  
P. Schotman ◽  
K. W. A. Wirtz ◽  
...  
Keyword(s):  
Protein Phosphorylation ◽  
Polyphosphoinositide Metabolism

Dopamine-induced changes in protein phosphorylation and polyphosphoinositide metabolism in rat hippocampus

1984 ◽  
Vol 291 (1) ◽  
pp. 73-81 ◽  
Author(s):  
R. Jork ◽  
P.N.E. de Graan ◽  
C.J. van Dongen ◽  
H. Zwiers ◽  
H. Matthies ◽  
...  
Keyword(s):  
Protein Phosphorylation ◽  
Rat Hippocampus ◽  
Induced Changes ◽  
Polyphosphoinositide Metabolism

scholarly journals Corticotropin-(1–24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain

1981 ◽  
Vol 194 (1) ◽  
pp. 283-291 ◽  
Author(s):  
J Jolles ◽  
H Zwiers ◽  
A Dekker ◽  
K W A Wirtz ◽  
W H Gispen
Keyword(s):  
Phosphatidic Acid ◽  
Protein Phosphorylation ◽  
Subcellular Fraction ◽  
Membrane Phospholipids ◽  
Cytosol Fraction ◽  
Phosphatidylinositol Bisphosphate ◽  
Phosphorylation Of Proteins ◽  
Synaptosomal Fraction ◽  
Phosphatidylinositol Phosphate ◽  
Polyphosphoinositide Metabolism

1. Effects of corticotropin-(1–24)-tetracosapeptide on the endogenous phosphorylation of proteins and lipids were studied in a membrane/cytosol fraction prepared from a lysed crude mitochondrial/synaptosomal fraction. 2. The labelling of proteins and lipids was monitored by incubation of the subcellular fraction for 10s with [gamma-32P]ATP. 3. The phosphorylation of proteins was dose-dependently inhibited by the peptide (40% of control incubations at 100 microM-corticotropin). 4. Of the membrane phospholipids only phosphatidylinositol phosphate, phosphatidylinositol bisphosphate and phosphatidic acid became labelled. Corticotropin dose-dependently increased the formation of phosphatidylinositol bisphosphate and inhibited the production of phosphatidic acid (470% and 50% respectively of control incubations, at 100 microM of the peptide) and had no effect on phosphatidylinositol phosphate. 5. Phosphatase activity was observed to act on phosphatidylinositol bisphosphate, phosphatidylinositol phosphate and phosphoprotein but not on phosphatidic acid. 6. Corticotropin interacted with the kinases rather than with the phosphatases. 7. The formation of phosphatidylinositol bisphosphate and phosphatidic acid was maximal at 1–10mM-Mg2+ in the absence of Ca2+, and the production of phosphatidylinositol phosphate was maximal at 30mM-Mg2+. 8. The basal value of lipid phosphorylation decreased with increasing Ca2+ concentration. 9. Ca2+ abolished the effect of corticotropin on phosphatidylinositol bisphosphate formation (470%, 190% and 100% of control incubations at respectively 0, 0.1 and 1 mM-Ca2+). 10. The data provide evidence that the effects of corticotropin on protein phosphorylation and on polyphosphoinositide metabolism in brain membranes are related.

Involvement of protein phosphorylation in the sensitivity of photosystem II to strong illumination

1994 ◽  
Vol 92 (1) ◽  
pp. 181-187
Author(s):  
Maria T. Giardi ◽  
Josef Komenda ◽  
Jiri Masojidek
Keyword(s):  
Photosystem Ii ◽  
Protein Phosphorylation

298-OR: Disruption of Multiple Cell-Autonomous Protein Phosphorylation Networks Underlies Muscle Insulin Resistance in Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 298-OR
Author(s):  
THIAGO M. BATISTA ◽  
NICOLAI J. WEWER ALBRECHTSEN ◽  
JULEEN R. ZIERATH ◽  
MATTHIAS MANN ◽  
C. RONALD KAHN
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Protein Phosphorylation ◽  
Muscle Insulin Resistance ◽  
Multiple Cell

Alteration of phosphoinositide metabolism, protein phosphorylation, and carbohydrate levels in sciatic nerve from Wistar fatty diabetic rats

Diabetes ◽  
1989 ◽  
Vol 38 (3) ◽  
pp. 373-378 ◽  
Author(s):  
L. N. Berti-Mattera ◽  
J. Lowery ◽  
S. F. Day ◽  
R. G. Peterson ◽  
J. Eichberg
Keyword(s):  
Sciatic Nerve ◽  
Protein Phosphorylation ◽  
Diabetic Rats ◽  
Phosphoinositide Metabolism ◽  
Carbohydrate Levels
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