Role of DNA polymerase γ in adenovirus DNA replication

Nature ◽  
1978 ◽  
Vol 276 (5687) ◽  
pp. 532-534 ◽  
Author(s):  
PETER C. VAN DER VLIET ◽  
MARIJKE M. KWANT
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Polymerase Γ

scholarly journals Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae

2018 ◽  
Vol 8 (2) ◽  
pp. 754-754
Author(s):  
Likui Zhang ◽  
Yanchao Huang ◽  
Xinyuan Zhu ◽  
Yuxiao Wang ◽  
Haoqiang Shi ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Polymerase Δ

scholarly journals Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae

2017 ◽  
Vol 8 (2) ◽  
pp. 754-754
Author(s):  
Likui Zhang ◽  
Yanchao Huang ◽  
Xinyuan Zhu ◽  
Yuxiao Wang ◽  
Haoqiang Shi ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Polymerase Δ

scholarly journals Role of Homodimerization of Human Cytomegalovirus DNA Polymerase Accessory Protein UL44 in Origin-Dependent DNA Replication in Cells

2008 ◽  
Vol 82 (24) ◽  
pp. 12574-12579 ◽  
Author(s):  
Elisa Sinigalia ◽  
Gualtiero Alvisi ◽  
Beatrice Mercorelli ◽  
Donald M. Coen ◽  
Gregory S. Pari ◽  
...  
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Human Cytomegalovirus ◽  
Nuclear Localization ◽  
Accessory Protein ◽  
C Terminus ◽  
Cellular Context ◽  
In Cells

ABSTRACT The presumed processivity subunit of human cytomegalovirus (HCMV) DNA polymerase, UL44, forms homodimers. The dimerization of UL44 is important for binding to DNA in vitro; however, whether it is also important for DNA replication in a cellular context is unknown. Here we show that UL44 point mutants that are impaired for dimerization, but not for nuclear localization or interaction with the C terminus of the polymerase catalytic subunit, are not capable of supporting HCMV oriLyt-dependent DNA replication in cells. These data suggest that the disruption of UL44 homodimers could represent a novel anti-HCMV strategy.

scholarly journals The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication.

1993 ◽  
Vol 12 (12) ◽  
pp. 4555-4566 ◽  
Author(s):  
K.L. Collins ◽  
A.A. Russo ◽  
B.Y. Tseng ◽  
T.J. Kelly
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Polymerase Alpha ◽  
Human Dna

scholarly journals Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunit.

1995 ◽  
Vol 15 (2) ◽  
pp. 883-891 ◽  
Author(s):  
M Foiani ◽  
G Liberi ◽  
G Lucchini ◽  
P Plevani
Keyword(s):  
Cell Cycle ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Posttranslational Modifications ◽  
S Phase ◽  
Dna Polymerase Alpha ◽  
B Subunit ◽  
Initiation Of Dna Replication ◽  
Cycle Dependent

The yeast DNA polymerase alpha-primase B subunit functions in initiation of DNA replication. This protein is present in two forms, of 86 and 91 kDa, and the p91 polypeptide results from cell cycle-regulated phosphorylation of p86. The B subunit present in G1 arises by dephosphorylation of p91 while cells are exiting from mitosis, becomes phosphorylated in early S phase, and is competent and sufficient to initiate DNA replication. The B subunit transiently synthesized as a consequence of periodic transcription of the POL12 gene is phosphorylated no earlier than G2. Phosphorylation of the B subunit does not require execution of the CDC7-dependent step and ongoing DNA synthesis. We suggest that posttranslational modifications of the B subunit might modulate the role of DNA polymerase alpha-primase in DNA replication.

scholarly journals Role of DNA polymerase alpha and DNA primase in simian virus 40 DNA replication in vitro.

1986 ◽  
Vol 83 (9) ◽  
pp. 2869-2873 ◽  
Author(s):  
Y. Murakami ◽  
C. R. Wobbe ◽  
L. Weissbach ◽  
F. B. Dean ◽  
J. Hurwitz
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Dna Polymerase Alpha ◽  
Dna Primase

scholarly journals The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Bertil Macao ◽  
Jay P. Uhler ◽  
Triinu Siibak ◽  
Xuefeng Zhu ◽  
Yonghong Shi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Exonuclease Activity ◽  
Mitochondrial Dna Replication ◽  
Dna Polymerase Γ
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