Potential for variability through multiple gene products of bacteriophage ΦX174

Nature ◽  
1978 ◽  
Vol 274 (5666) ◽  
pp. 34-37 ◽  
Author(s):  
Thomas J. Pollock ◽  
Irwin Tessman ◽  
Ethel S. Tessman
Keyword(s):  
Gene Products ◽  
Multiple Gene

New insights into heparan sulphate biosynthesis from the study of mutant mice

2002 ◽  
Vol 69 ◽  
pp. 47-57 ◽  
Author(s):  
Catherine L. R. Merry ◽  
John T. Gallagher
Keyword(s):  
Growth Factors ◽  
Biosynthetic Pathway ◽  
Heparan Sulphate ◽  
Mutant Mice ◽  
Gene Products ◽  
Multiple Gene ◽  
Adhesion Proteins ◽  
Ligand Interactions

Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS–ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st-/- mice.

Molecular Insights into Regulation of L-Type Ca Channel Function

Physiology ◽  
1991 ◽  
Vol 6 (6) ◽  
pp. 277-281 ◽  
Author(s):  
P Lory ◽  
G Varadi ◽  
A Schwartz
Keyword(s):  
Structure Function ◽  
Splice Variants ◽  
Ca Channel ◽  
Gene Products ◽  
Ca Channels ◽  
Channel Activity ◽  
Excitable Cells ◽  
Multiple Gene ◽  
Channel Function ◽  
Voltage Dependent

The diversity of voltage-dependent Ca channels is well documented. How excitable cells produce their specific Ca channel activity is being approached by structure-function studies. The implications of multiple gene products, splice variants, and subunit assembly in Ca channel function are updated in this review.

Multiple gene products from a single vector: ‘self-cleaving’ 2A peptides

Gene Therapy ◽  
2004 ◽  
Vol 11 (23) ◽  
pp. 1673-1674 ◽  
Author(s):  
PA Radcliffe ◽  
KA Mitrophanous
Keyword(s):  
Gene Products ◽  
Multiple Gene

scholarly journals Delivering multiple gene products in the brain from a single adeno-associated virus vector

Gene Therapy ◽  
2009 ◽  
Vol 16 (11) ◽  
pp. 1314-1319 ◽  
Author(s):  
S B Foti ◽  
R J Samulski ◽  
T J McCown
Keyword(s):  
Virus Vector ◽  
Gene Products ◽  
Adeno Associated Virus ◽  
Multiple Gene ◽  
The Brain

Epstein-Barr virus evasion of CD8+ and CD4+ T cell immunity via concerted actions of multiple gene products

2008 ◽  
Vol 18 (6) ◽  
pp. 397-408 ◽  
Author(s):  
Maaike E. Ressing ◽  
Daniëlle Horst ◽  
Bryan D. Griffin ◽  
Judy Tellam ◽  
Jianmin Zuo ◽  
...  
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
T Cell Immunity ◽  
Cd4 T Cell ◽  
Gene Products ◽  
Multiple Gene ◽  
Barr Virus ◽  
Cell Immunity ◽  
Epstein Barr
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