A virus-induced non-virion antigen specific for transformation at the surface of RSV-transformed fibroblasts

Nature ◽  
1978 ◽  
Vol 273 (5661) ◽  
pp. 381-383 ◽  
Author(s):  
PAOLO M. COMOGLIO ◽  
MARIA PRAT ◽  
MARILENA BERTINI
Keyword(s):  
Transformed Fibroblasts ◽  
Virion Antigen

scholarly journals Adenyl Cyclase in Normal and Transformed Fibroblasts in Tissue Culture

1971 ◽  
Vol 246 (18) ◽  
pp. 5785-5790
Author(s):  
Charles V. Peery ◽  
George S. Johnson ◽  
Ira Pastan
Keyword(s):  
Tissue Culture ◽  
Adenyl Cyclase ◽  
Transformed Fibroblasts

Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells

2007 ◽  
Vol 213 (1) ◽  
pp. 212-220 ◽  
Author(s):  
Renaud Poincloux ◽  
Céline Cougoule ◽  
Thomas Daubon ◽  
Isabelle Maridonneau-Parini ◽  
Véronique Le Cabec
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Transformed Fibroblasts

RSV transformed fibroblasts and monocytes share peculiar adhesion sites

1986 ◽  
Vol 10 (3) ◽  
pp. 161-161
Author(s):  
P MARCHISIO ◽  
D CIRILLO ◽  
F GIANCOTTI ◽  
P COMOGLIO ◽  
G TARONE
Keyword(s):  
Adhesion Sites ◽  
Transformed Fibroblasts

scholarly journals Heavily Isotype-Dependent Protective Activities of Human Antibodies against Vaccinia Virus Extracellular Virion Antigen B5

2009 ◽  
Vol 83 (23) ◽  
pp. 12355-12367 ◽  
Author(s):  
Mohammed Rafii-El-Idrissi Benhnia ◽  
Megan M. McCausland ◽  
John Laudenslager ◽  
Steven W. Granger ◽  
Sandra Rickert ◽  
...  
Keyword(s):  
Antibody Response ◽  
Vaccinia Virus ◽  
Smallpox Vaccine ◽  
Human Antibody ◽  
Human Mabs ◽  
Complement Components ◽  
Vaccinia Virion ◽  
Virion Antigen

ABSTRACT Antibodies against the extracellular virion (EV or EEV) form of vaccinia virus are an important component of protective immunity in animal models and likely contribute to the protection of immunized humans against poxviruses. Using fully human monoclonal antibodies (MAbs), we now have shown that the protective attributes of the human anti-B5 antibody response to the smallpox vaccine (vaccinia virus) are heavily dependent on effector functions. By switching Fc domains of a single MAb, we have definitively shown that neutralization in vitro—and protection in vivo in a mouse model—by the human anti-B5 immunoglobulin G MAbs is isotype dependent, thereby demonstrating that efficient protection by these antibodies is not simply dependent on binding an appropriate vaccinia virion antigen with high affinity but in fact requires antibody effector function. The complement components C3 and C1q, but not C5, were required for neutralization. We also have demonstrated that human MAbs against B5 can potently direct complement-dependent cytotoxicity of vaccinia virus-infected cells. Each of these results was then extended to the polyclonal human antibody response to the smallpox vaccine. A model is proposed to explain the mechanism of EV neutralization. Altogether these findings enhance our understanding of the central protective activities of smallpox vaccine-elicited antibodies in immunized humans.

Identification and Localization of Phosphoproteins in v-onc Transformed Fibroblasts by Means of Phosphotyrosine Antibodies

1985 ◽  
pp. 97-112
Author(s):  
P. M. Comoglio ◽  
D. Cirillo ◽  
M. F. Di Renzo ◽  
R. Ferracini ◽  
F. G. Giancotti ◽  
...  
Keyword(s):  
Transformed Fibroblasts
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