Chemical modification of DNA polymerase phosphoprotein from avian myeloblastosis virus

Nature ◽  
1977 ◽  
Vol 266 (5597) ◽  
pp. 27-31 ◽  
Author(s):  
Chris M. Tsiapalis
Keyword(s):  
Chemical Modification ◽  
Dna Polymerase ◽  
Avian Myeloblastosis Virus

scholarly journals Inhibition of reverse transcriptases by seminalplasmin

1983 ◽  
Vol 209 (1) ◽  
pp. 183-188 ◽  
Author(s):  
E S P Reddy ◽  
M R Das ◽  
E P Reddy ◽  
P M Bhargava
Keyword(s):  
Dna Polymerase ◽  
Reproductive Tract ◽  
Seminal Fluid ◽  
Potent Inhibitor ◽  
Female Reproductive Tract ◽  
Dna Polymerase I ◽  
Avian Myeloblastosis Virus ◽  
Antibacterial Protein ◽  
Reverse Transcriptases ◽  
Polymerase I

Seminalplasmin, an antibacterial protein present in bovine seminal plasma, is shown to be a potent inhibitor of reverse transcriptases (RNA-dependent DNA nucleotidyltransferases). Seminalplasmin inhibits RNA-directed, hybrid-directed, and DNA-directed DNA-polymerizing activities of purified reverse transcriptase from avian myeloblastosis virus and from crude viral lysates of several retroviruses by binding to the enzyme, at least in the case of avian myeloblastosis virus. Seminalplasmin does not inhibit significantly DNA synthesis either by Escherichia coli DNA polymerase I, or a mammalian alpha-DNA polymerase. The presence of seminalplasmin in the seminal fluid could provide protection to the male and/or the female reproductive tract against retroviruses.

Model RNA-directed DNA synthesis by avian myeloblastosis virus DNA polymerase and its associated RNase H

Biochemistry ◽  
1979 ◽  
Vol 18 (15) ◽  
pp. 3210-3219 ◽  
Author(s):  
Kenneth F. Watson ◽  
Peter L. Schendel ◽  
Mae J. Rosok ◽  
Leonard R. Ramsey
Keyword(s):  
Dna Synthesis ◽  
Dna Polymerase ◽  
Rnase H ◽  
Avian Myeloblastosis Virus
Sign in / Sign up

Export Citation Format

Share Document