scholarly journals Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures

Nature ◽  
1976 ◽  
Vol 262 (5567) ◽  
pp. 402-404 ◽  
Author(s):  
STUART H. YUSPA ◽  
ULRIKE LICHTI ◽  
THERESA BEN ◽  
ELROY PATTERSON ◽  
HENRY HENNINGS ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Epidermal Cell ◽  
Cell Cultures ◽  
Phorbol Esters ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Mouse Epidermal Cell

scholarly journals Ornithine decarboxylase activity and the onset of deoxyribonucleic acid synthesis in regenerating liver

1978 ◽  
Vol 170 (1) ◽  
pp. 123-127 ◽  
Author(s):  
J A McGowan ◽  
N Fausto
Keyword(s):  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Time Course ◽  
Deoxyribonucleic Acid ◽  
Acid Synthesis ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Low Protein ◽  
Deoxyribonucleic Acid Synthesis ◽  
Second Peak

Compared with normally fed animals, rats fed on a low-protein diet for 3 days exhibit a considerable delay in DNA synthesis after partial hepatectomy. In the regenerating livers of these animals (a) the timing of the first peak of ornithine decarboxylase activity is not altered and (b) the second peak of enzyme activity is delayed by a few hours, but polyamine concentrations are similar to those of normally fed rats. The results suggest that regardless of the possible effect of polyamines on DNA synthesis, the time course of ornithine decarboxylase activity appears to be independent of the onset of DNA replication in regenerating livers.

Ornithine decarboxylase activity and DNA synthesis in Morris hepatomas 51123-C and 7800

Life Sciences ◽  
1976 ◽  
Vol 18 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Michael W. Pariza ◽  
Susumu Yanagi ◽  
James A. Gurr ◽  
Donald E. Bushnell ◽  
Harold P. Morris ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity

Effects of Acute and Subchronic Exposure of Topically Applied Fullerene Extracts on the Mouse Skin

1993 ◽  
Vol 9 (4) ◽  
pp. 623-630 ◽  
Author(s):  
Mark A. Nelson ◽  
Frederick E. Domann ◽  
G. Tim Bowden ◽  
Stephen B. Hooser ◽  
Quintus Fernando ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Mouse Skin ◽  
Tumor Formation ◽  
Skin Tumor ◽  
Toxic Effects ◽  
Exposure Level ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Acute Toxic

The recent discovery that fullerenes (C60) can be produced in macroscopic quantities has sparked much interest in the chemistry of this unusual molecule. Concerns have also arose about the potential carcinogenic effects of this molecule. We have addressed the potential acute and subchronic toxic effects of fullerenes applied in benzene on the mouse skin. The acute toxic effects measured in this study included epidermal DNA synthesis and the induction of ornithine decarboxylase activity in the epidermis. At the topical dose of fullerenes used in these studies (i.e., 200 ug), we found no effect on either DNA synthesis or ornithine decarboxylase activity over a 72 hour time course after treatment. The subchronic effects of the fullerenes as a mouse skin tumor promoter was assessed by repeatedly applying the chemical to the skin after initiation with the polycyclic aromatic hydrocarbon, 7,12-dimethlybenz-anthracene (DMBA). Repeated administration of the fullerenes for up to 24 weeks post-initiation did not result in either benign or malignant skin tumor formation, whereas promotion with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the formation of benign skin tumors. Our data indicate that fullerenes applied in benzene at a likely industrial exposure level do not cause acute toxic effects on the mouse skin epidermis.

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