p14ARF links the tumour suppressors RB and p53

Nature ◽  
10.1038/25867 ◽  
1998 ◽  
Vol 395 (6698) ◽  
pp. 124-125 ◽  
Author(s):  
Stewart Bates ◽  
Andrew C. Phillips ◽  
Paula A. Clark ◽  
Francesca Stott ◽  
Gordon Peters ◽  
...  
Keyword(s):  
Tumour Suppressors

Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma

2013 ◽  
Vol 230 (3) ◽  
pp. 298-309 ◽  
Author(s):  
Chia-Huei Lee ◽  
Thian-Sze Wong ◽  
Jimmy Yu-Wai Chan ◽  
Shao-Chun Lu ◽  
Pinpin Lin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epigenetic Regulation ◽  
Tumour Suppressors

Tumour suppressors—a fly's perspective

2003 ◽  
Vol 39 (10) ◽  
pp. 1355-1362 ◽  
Author(s):  
J.E. Sutcliffe ◽  
M. Korenjak ◽  
A. Brehm
Keyword(s):  
Tumour Suppressors

MicroRNAs as Therapeutic Agents: The Future of the Battle Against Cancer

2019 ◽  
Vol 18 (30) ◽  
pp. 2544-2554 ◽  
Author(s):  
Sumit Biswas
Keyword(s):  
Drug Resistance ◽  
Cancer Biology ◽  
Therapeutic Agents ◽  
Nucleotide Level ◽  
Target Mrnas ◽  
Sequencing Technologies ◽  
Tumour Suppressors ◽  
The Future ◽  
New Strategies

Since their discovery in the 1990’s, the study of a class of non-coding, single-stranded RNAs, christened the microRNAs has opened up new vistas in the field of cancer biology. MicroRNAs bind to their target mRNAs to act as either oncogenes or tumour suppressors. With the near-complete elucidation of the biogenesis pathway, and the advent of rapid sequencing technologies, microRNAs have slowly cemented their place as essential biomarkers for delineating the progression, metastasis, relapse or drug resistance of cancer. Being crucial players in the cancer pathway, there has been considerable urgency in designing molecules - both at the nucleotide and non-nucleotide level to counter the effects of their binding. A number of different approaches have yielded quite a body of compounds which have been found to be effective in the treatment of various tumours across many different organs. In this study, the focus is on the review of the timeline of discovery and characterization of microRNAs, underlining their importance in different cancers, shedding light on the discovery of anti-microRNA compounds and illustrating their uses in deriving new strategies to combat cancer.

scholarly journals Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors

EBioMedicine ◽  
2018 ◽  
Vol 36 ◽  
pp. 252-265 ◽  
Author(s):  
Hongsai Chen ◽  
Lu Xue ◽  
He Huang ◽  
Hantao Wang ◽  
Xiaoman Zhang ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Tumour Suppressors

Centrosomes and tumour suppressors

2002 ◽  
Vol 14 (6) ◽  
pp. 700-705 ◽  
Author(s):  
Harold A Fisk ◽  
Christopher P Mattison ◽  
Mark Winey
Keyword(s):  
Tumour Suppressors
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