High affinity uptake of neurotransmitter amino acids (reply)

Nature ◽  
1975 ◽  
Vol 253 (5491) ◽  
pp. 481-482 ◽  
Author(s):  
LEVI ◽  
RAITERI
Keyword(s):  
Amino Acids ◽  
Neurotransmitter Amino Acids ◽  
High Affinity ◽  
High Affinity Uptake

A high-affinity uptake system for branched-chain amino acids inSaccharomyces cerevisiae

Yeast ◽  
1991 ◽  
Vol 7 (9) ◽  
pp. 933-941 ◽  
Author(s):  
Søren Tullin ◽  
Claes Gjermansen ◽  
Morten C. Kielland-Brandt
Keyword(s):  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Uptake System ◽  
High Affinity ◽  
High Affinity Uptake ◽  
Branched Chain

Molecular docking studies of tea (Thea sinensis Linn.) polyphenols inhibition pattern with Rat P-glycoprotein

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Babar Ali ◽  
Qazi Mohammad Sajid Jamal ◽  
Showkat R. Mir ◽  
Saiba Shams ◽  
Mohammad Amjad Kamal
Keyword(s):  
Amino Acids ◽  
Molecular Docking ◽  
Binding Energy ◽  
Oral Administration ◽  
Docking Studies ◽  
Vital Role ◽  
Glycoprotein P ◽  
High Affinity ◽  
P Glycoprotein ◽  
Inhibition Pattern

AbstractSince 3000 B.C., evergreen plant Thea sinensis (Theaceae) is used both as a social and medicinal beverage. Leaves of T. sinensis contain amino acids, vitamins, caffeine, polysaccharides and polyphenols. Most of the natural medicinal actions of tea are due to the availability and abundance of polyphenols mainly catechins. It has also been stated that some catechins were absorbed more rapidly than other compounds after the oral administration of tea and could increase the bio-enhancing activities of anticancer drugs by inhibiting P-glycoprotein (P-gp). The results of the molecular docking showed that polyphenols bind easily to the active P-gp site. All compounds exhibited fluctuating binding affinity ranged from −11.67 to −8.36 kcal/mol. Observed binding energy required for theaflavin to bind to P-gp was lowest (−11.67 kcal/mol). The obtained data that supports all the selected polyphenols inhibited P-gp and therefore may enhance the bioavailability of drugs. This study may play a vital role in finding hotspots in P-gp and eventually may be proved useful in designing compounds with high affinity and specificity to the protein.

scholarly journals The structural basis for high‐affinity uptake of lignin‐derived aromatic compounds by proteobacterial TRAP transporters

FEBS Journal ◽  
2021 ◽  
Author(s):  
Claudine Bisson ◽  
Robert C. Salmon ◽  
Laura West ◽  
John B. Rafferty ◽  
Andrew Hitchcock ◽  
...  
Keyword(s):  
Aromatic Compounds ◽  
Structural Basis ◽  
High Affinity ◽  
High Affinity Uptake
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