Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes

Nature ◽  
1974 ◽  
Vol 251 (5472) ◽  
pp. 230-233 ◽  
Author(s):  
R. M. ZINKERNAGEL
Keyword(s):  
Listeria Monocytogenes ◽  
Cell Mediated Immunity ◽  
Gene Complex

scholarly journals Listeria monocytogenes meningitis in an immunocompetent 18-year old patient as a possible diagnostic and therapeutical problem

2013 ◽  
Vol 70 (10) ◽  
pp. 976-978
Author(s):  
Miodrag Vrbic ◽  
Marina Dinic ◽  
Maja Jovanovic ◽  
Aleksandar Rankovic ◽  
Lidija Popovic-Dragonjic ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Case Report ◽  
Listeria Monocytogenes ◽  
Bacterial Meningitis ◽  
Initial Treatment ◽  
Clinical Effect ◽  
Complete Recovery ◽  
Cell Mediated Immunity ◽  
The Third ◽  
Appropriate Treatment

Introduction. Listeria monocytogenes is the third most frequent cause of bacterial meningitis in adults. It commonly affects persons with defective cell-mediated immunity or advanced age, and only a few patients with no underlying predisposition have been reported. Case report. We presented an previously healthy, 18-year-old man with typical clinical features of meningitis. On the account of earlier treatment with ceftriaxone and cerebrospinal fluid finding, an assumption of partially treated bacterial meningitis was made. The initial treatment with vancomycin and ceftriaxone, substituted on day 4 with meropenem, did not produce any clinical effect. On day 6 Listeria monocytogenes was isolated and, even as late as that, the administration of ampicillin was followed by complete recovery of the patient. Conclusion. In younger, immunocompetent individuals, in spite of the existent diagnostic and therapeutic problems, the subacute course of Listeria monocytogenes meningitis provides enough time for appropriate treatment and favorable disease outcome.

scholarly journals Listeria monocytogenes: The Impact of Cell Death on Infection and Immunity

Pathogens ◽  
2018 ◽  
Vol 7 (1) ◽  
pp. 8 ◽  
Author(s):  
Courtney McDougal ◽  
John-Demian Sauer
Keyword(s):  
Cell Death ◽  
Listeria Monocytogenes ◽  
Host Cell ◽  
Acute Infection ◽  
Host Cells ◽  
Cell Mediated Immunity ◽  
Cell Death Pathways ◽  
Host Cell Death ◽  
The Impact

Listeria monocytogenes has evolved exquisite mechanisms for invading host cells and spreading from cell-to-cell to ensure maintenance of its intracellular lifecycle. As such, it is not surprising that loss of the intracellular replication niche through induction of host cell death has significant implications on the development of disease and the subsequent immune response. Although L. monocytogenes can activate multiple pathways of host cell death, including necrosis, apoptosis, and pyroptosis, like most intracellular pathogens L. monocytogenes has evolved a series of adaptations that minimize host cell death to promote its virulence. Understanding how L. monocytogenes modulates cell death during infection could lead to novel therapeutic approaches. In addition, as L. monocytogenes is currently being developed as a tumor immunotherapy platform, understanding how cell death pathways influence the priming and quality of cell-mediated immunity is critical. This review will focus on the mechanisms by which L. monocytogenes modulates cell death, as well as the implications of cell death on acute infection and the generation of adaptive immunity.

scholarly journals Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.

1995 ◽  
Vol 92 (9) ◽  
pp. 3987-3991 ◽  
Author(s):  
H. Shen ◽  
M. K. Slifka ◽  
M. Matloubian ◽  
E. R. Jensen ◽  
R. Ahmed ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Live Vaccine ◽  
Cell Mediated Immunity

IL-12-assisted immunization generates CD4+ T cell-mediated immunity to Listeria monocytogenes

2003 ◽  
Vol 222 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Mark A. Miller ◽  
Marianne J. Skeen ◽  
Christy L. Lavine ◽  
H. Kirk Ziegler
Keyword(s):  
Listeria Monocytogenes ◽  
T Cell ◽  
Cd4 T Cell ◽  
Cell Mediated Immunity

scholarly journals Conditional Lethality Yields a New Vaccine Strain of Listeria monocytogenes for the Induction of Cell-Mediated Immunity

2005 ◽  
Vol 73 (8) ◽  
pp. 5065-5073 ◽  
Author(s):  
Zhongxia Li ◽  
Xinyan Zhao ◽  
Darren E. Higgins ◽  
Fred R. Frankel
Keyword(s):  
Listeria Monocytogenes ◽  
Inducible Promoter ◽  
Vector System ◽  
Cell Mediated Immunity ◽  
Multicopy Plasmid ◽  
Listeriolysin O ◽  
Delivery Vector ◽  
Immunodeficiency Virus ◽  
Dependent Growth

ABSTRACT Listeria monocytogenes is a gram-positive intracellular pathogen that can enter phagocytic and nonphagocytic cells and colonize their cytosols. Taking advantage of this property to generate an intracellular vaccine delivery vector, we previously described a mutant strain of L. monocytogenes, Δdal Δdat, which is unable to synthesize cell wall by virtue of deletions in two genes (dal and dat) required for d-alanine synthesis. This highly attenuated strain induced long-lived protective systemic and mucosal immune responses in mice when administered in the transient presence of d-alanine. We have now increased the usefulness of this organism as a vaccine vector by use of an inducible complementation system that obviates the need for exogenous d-alanine administration. The strain expresses a copy of the Bacillus subtilis racemase gene under the control of a tightly regulated isopropyl-β-d-thiogalactopyranoside (IPTG)-inducible promoter present on a multicopy plasmid. This bacterium demonstrates strict dose-dependent growth in the presence of IPTG. After removal of inducer, bacterial growth ceased within two replication cycles. Following infection of mice in the absence of IPTG or d-alanine, the bacterium survived in vivo for less than 3 days. Nevertheless, a single immunization elicited a state of long-lasting protective immunity against wild-type L. monocytogenes and induced a subset of effector listeriolysin O-specific CD11a+ CD8+ T cells in spleen and other tissues that was strongly enhanced after secondary immunization. This improved L. monocytogenes vector system may have potential use as a live vaccine against human immunodeficiency virus, other infectious diseases, and cancer.

Listeria meningitis in an immunocompetent child

2019 ◽  
Vol 49 (3) ◽  
pp. 243-245
Author(s):  
Krishna Mohan Gulla ◽  
Dhiren Gupta ◽  
Anil Sachdev
Keyword(s):  
Listeria Monocytogenes ◽  
Dairy Products ◽  
Case Reports ◽  
The Elderly ◽  
Cell Mediated Immunity ◽  
Clinical Infection ◽  
Gram Positive ◽  
Immunocompetent Child ◽  
Facultative Anaerobic ◽  
Listeria Meningitis

Listeria monocytogenes is a gram-positive, facultative anaerobic, motile bacillus widely spread in the environment. However, clinical infection in humans is uncommon. The route of infection is often through ingestion of raw vegetables, meat and unpasteurised dairy products. Listeria is an uncommon cause of meningitis in immunocompetent individuals, but it should be considered strongly in neonates and the elderly, and it should also be considered in those with impaired cell-mediated immunity. 1 , 2 Only a few case reports of invasive listeriosis in humans have been reported from India. 3 – 8 In our case, a 13-year-old previously healthy boy was thus diagnosed.

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