Simian virus 40 in a human cancer

Nature ◽  
1974 ◽  
Vol 249 (5456) ◽  
pp. 421-424 ◽  
Author(s):  
Federico Soriano ◽  
Charles E. Shelburne ◽  
Muharrem Gökcen
Keyword(s):  
Human Cancer ◽  
Simian Virus 40 ◽  
Simian Virus

scholarly journals Simian virus 40 and cancer

2011 ◽  
pp. 131-140
Author(s):  
Sandra Eliasz ◽  
Michele Carbone ◽  
Maurizio Bocchetta
Keyword(s):  
Molecular Biology ◽  
Human Population ◽  
Animal Studies ◽  
Cell Transformation ◽  
Human Cancer ◽  
Mesothelial Cell ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Oncogenic Virus ◽  
Experimental Approaches

Since its discovery in 1960 as a contaminant of poliovaccines, Simian Virus 40 (SV40) has been the object of extensive studies to assess whether this oncogenic virus plays a role in human carcinogenesis. Over the last two decades, this question has met with broad scepticism. However, there is increasing evidence linking SV40 to specific types of human cancer, especially malignant mesothelioma. Recently, two laboratories using different experimental approaches independently confirmed that SV40 acts synergistically with environmental fibers to promote mesothelial cell transformation and mesothelioma. Most of the scepticism concerning SV40 and cancer was due to the lack of clear epidemiologic data. However, it is still not clear how SV40 circulates in the human population, making the identification of SV40-exposed versus non-exposed cohorts problematic. Consequently, the most helpful insights into SV40-mediated carcinogenesis have come from molecular pathology, cell and molecular biology, and from animal studies.

scholarly journals Investigation of the SV40 – Human Cancer Association: Look for the Full Signature of the Virus

2001 ◽  
Vol 17 (3) ◽  
pp. 159-161 ◽  
Author(s):  
Keerti V. Shah ◽  
Dana E. M. Rollison
Keyword(s):  
Risk Factors ◽  
Tumor Cell ◽  
Cancer Patients ◽  
Sensitivity And Specificity ◽  
Human Cancer ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Viral Integration ◽  
Human Community ◽  
Sv40 Infection

In the controversy about the association of simian virus 40 with human cancers, the greatest problem is the ascertainment of SV40 exposure. This difficulty would be resolved if one were to look for all components of SV40 infection. How does SV 40 circulate in the human community? Do cancer patients with SV40-positive tumors have serological correlates of SV 40 infection and of SV40-induced cancer? SV40 association with a cancer should be studied in the context of the known risk factors for that cancer. The tumor cell-virus relationship should be characterized with respect to viral integration and viral localization to the tumor cell. Specimens should be masked and the assays should include panels of specimens to estimate analytic sensitivity and specificity. In view of the rarity of some of the tumors reported to be associated with SV40, a multi-institutional investigation initiated and coordinated by the NIH would be most effective.

Simian virus 40(SV40) and human cancer: a review of the serological data

2004 ◽  
Vol 14 (4) ◽  
pp. 231-239 ◽  
Author(s):  
Keerti V. Shah ◽  
Denise A. Galloway ◽  
Wendy A. Knowles ◽  
Raphael P. Viscidi
Keyword(s):  
Human Cancer ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Serological Data

scholarly journals Polio vaccines, Simian Virus 40, and human cancer: the epidemiologic evidence for a causal association

Oncogene ◽  
2004 ◽  
Vol 23 (38) ◽  
pp. 6535-6540 ◽  
Author(s):  
Tam Dang-Tan ◽  
Salaheddin M Mahmud ◽  
Riccardo Puntoni ◽  
Eduardo L Franco
Keyword(s):  
Human Cancer ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Causal Association ◽  
Epidemiologic Evidence

Is There a Role for SV40 in Human Cancer?

2006 ◽  
Vol 24 (26) ◽  
pp. 4356-4365 ◽  
Author(s):  
Danielle L. Poulin ◽  
James A. DeCaprio
Keyword(s):  
Human Cancer ◽  
Simian Virus 40 ◽  
The United States ◽  
Simian Virus ◽  
Human Tumors ◽  
Direct Role ◽  
Potential Health ◽  
Polio Vaccination ◽  
Sv40 Infection ◽  
Positive Correlations

The question of whether Simian Virus 40 (SV40) can cause human tumors has been one of the most highly controversial topics in cancer research during the last 50 years. The longstanding debate began with the discovery of SV40 as a contaminant in poliovirus vaccine stocks that were used to inoculate approximately 100 million children and adults in the United States between 1955 and 1963, and countless more throughout the world. Concerns regarding the potential health risk of SV40 exposure were reinforced by studies demonstrating SV40's potential to transform human cells and promote tumor growth in animal models. Many studies have attempted to assess the relationship between the potential exposure of humans to SV40 and cancer incidence. Reports of the detection of SV40 DNA in a variety of cancers have raised serious concerns as to whether the inadvertent inoculation with SV40 has led to the development of cancer in humans. However, inconsistent reports linking SV40 with various tumor types has led to conflicting views regarding the potential of SV40 as a human cancer virus. Several recent studies suggest that older detection methodologies were flawed, and the limitations of these methods could account for most, if not all, of the positive correlations of SV40 in human tumors to date. Although many people may have been exposed to SV40 by polio vaccination, there is inadequate evidence to support widespread SV40 infection in the population, increased tumor incidence in those individuals who received contaminated vaccine, or a direct role for SV40 in human cancer.

scholarly journals New Associations of Human Papillomavirus, Simian Virus 40, and Epstein-Barr Virus with Human Cancer

2002 ◽  
Vol 94 (24) ◽  
pp. 1832-1836 ◽  
Author(s):  
M. Wong ◽  
J. S. Pagano ◽  
J. T. Schiller ◽  
S. S. Tevethia ◽  
N. Raab-Traub ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Epstein Barr Virus ◽  
Human Cancer ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
New Associations ◽  
Barr Virus ◽  
Epstein Barr
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