Prebiotic Activation Processes

Nature ◽  
1973 ◽  
Vol 244 (5416) ◽  
pp. 418-420 ◽  
Author(s):  
R. LOHRMANN ◽  
L. E. ORGEL
Keyword(s):  
Prebiotic Activation

scholarly journals Harnessing Chemical Energy for the Activation and Joining of Prebiotic Building Blocks

2019 ◽  
Author(s):  
Ziwei Liu ◽  
Long-Fei Wu ◽  
Jianfeng Xu ◽  
Claudia Bonfio ◽  
David Russell ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Carboxylic Acid ◽  
Peptide Nucleic Acid ◽  
Reactive Intermediates ◽  
Building Blocks ◽  
Acid System ◽  
Rna Oligomers ◽  
Prebiotic Activation ◽  
Simultaneous Activation ◽  
Acid Anhydrides

Simultaneous activation of carboxylates and phosphates provides multiple pathways for the generation of reactive intermediates, including mixed carboxylic acid-phosphoric acid anhydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids. These results indicate that unified prebiotic activation chemistry could have enabled the joining of building blocks in aqueous solution from a common pool and enabled the progression of a system towards higher complexity foreshadowing the modern encapsulated peptide-nucleic acid system

scholarly journals Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying

2020 ◽  
Vol 142 (35) ◽  
pp. 14810-14813 ◽  
Author(s):  
Stephanie J. Zhang ◽  
Daniel Duzdevich ◽  
Jack W. Szostak
Keyword(s):  
Prebiotic Activation

scholarly journals Tuning the reactivity of nitriles using Cu(ii) catalysis – potentially prebiotic activation of nucleotides

2018 ◽  
Vol 9 (35) ◽  
pp. 7053-7057 ◽  
Author(s):  
Ziwei Liu ◽  
Angelica Mariani ◽  
Longfei Wu ◽  
Dougal Ritson ◽  
Andrea Folli ◽  
...  
Keyword(s):  
Rna Degradation ◽  
Prebiotic Activation

A synergistic system was established involving activating nucleotides with nitriles using Cu(ii) and protecting RNA degradation by byproducts of alpha-aminonitriles.

Carbonyl Sulfide as a Prebiotic Activation Agent for Stereo- and Sequence-Selective, Amyloid-Templated Peptide Elongation

2019 ◽  
Vol 49 (4) ◽  
pp. 213-224 ◽  
Author(s):  
Radoslaw Bomba ◽  
Saroj K. Rout ◽  
Matthias Bütikofer ◽  
Witek Kwiatkowski ◽  
Roland Riek ◽  
...  
Keyword(s):  
Carbonyl Sulfide ◽  
Prebiotic Activation ◽  
Peptide Elongation

scholarly journals Harnessing Chemical Energy for the Activation and Joining of Prebiotic Building Blocks

2019 ◽  
Author(s):  
Ziwei Liu ◽  
Long-Fei Wu ◽  
Jianfeng Xu ◽  
Claudia Bonfio ◽  
David Russell ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Nucleic Acid ◽  
Carboxylic Acid ◽  
Peptide Nucleic Acid ◽  
Reactive Intermediates ◽  
Building Blocks ◽  
Rna Oligomers ◽  
Prebiotic Activation ◽  
Simultaneous Activation ◽  
Acid Anhydrides

Simultaneous activation of carboxylates and phosphates provides multiple pathways for the generation of reactive intermediates, including mixed carboxylic acid-phosphoric acid anhydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids. These results indicate that unified prebiotic activation chemistry could have enabled the joining of building blocks in aqueous solution from a common pool and enabled the progression of a system towards higher complexity foreshadowing the modern encapsulated peptide-nucleic acid systemThis paper has been accepted by Nature Chemistry<div>https://www.nature.com/articles/s41557-020-00564-3<br></div>

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