Inhibition of in vitro Immune Response by Treatment of Spleen Cell Suspensions with Anti-θ Serum

Nature ◽  
1970 ◽  
Vol 226 (5252) ◽  
pp. 1258-1259 ◽  
Author(s):  
ANNELIESE SCHIMPL ◽  
EBERHARD WECKER
1990 ◽  
Vol 20 (3) ◽  
pp. 165-174 ◽  
Author(s):  
A.B. Singh ◽  
K. Hiehle ◽  
P. Casale ◽  
S. Gerber ◽  
S. Nayar ◽  
...  

1979 ◽  
Vol 42 (1) ◽  
pp. 177-182 ◽  
Author(s):  
Marie-Agnès Delpierre ◽  
Jacques Panijel ◽  
Micheline Terquem ◽  
Jacqueline Maridat

1971 ◽  
Vol 2 (5) ◽  
pp. 399-410 ◽  
Author(s):  
Ken Shortman ◽  
Jon Palmer

1970 ◽  
Vol 132 (6) ◽  
pp. 1267-1278 ◽  
Author(s):  
Klaus-Ulrich Hartmann

The immune response to foreign erythrocytes was studied in vitro. Two subpopulations of cells were prepared. One was a population of bone marrow-derived spleen cells, taken from thymectomized, irradiated, and bone marrow-reconstituted mice; there was evidence that most of the precursors of the PFC had been present in this cell population, but few PFC developed in cultures of these cells alone in the presence of immunogenic erythrocytes. Another cell suspension was made from spleens of mice which had been irradiated and injected with thymus cells and erythrocytes; these cells were called educated T cells. The two cell suspensions together allow the formation of PFC in the presence of the erythrocytes which were used to educate the T cells, but not in the presence of noncross-reacting erythrocytes. If bone marrow-derived cells and T cells were kept in culture together with two different species of erythrocytes, and if one of the erythrocytes had been used to educate the T cells, then PFC against each of the erythrocytes could be detected.


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