Inhibitory Effect of a Synthetic Interferon Inducer on Murine Sarcoma and Leukaemia Virus Infection in vitro

Nature ◽  
1969 ◽  
Vol 224 (5219) ◽  
pp. 604-605 ◽  
Author(s):  
PADMAN S. SARMA ◽  
SAMUEL BARON ◽  
ROBERT J. HUEBNER ◽  
GRACE SHIU
Keyword(s):  
Virus Infection ◽  
Inhibitory Effect ◽  
Interferon Inducer ◽  
Leukaemia Virus ◽  
Murine Sarcoma

Inhibitory Effect of Interferon on Murine Sarcoma and Leukaemia Virus Infection in vitro

Nature ◽  
1969 ◽  
Vol 223 (5208) ◽  
pp. 845-846 ◽  
Author(s):  
PADMAN S. SARMA ◽  
GRACE SHIU ◽  
SAMUEL BARON ◽  
R. J. HUEBNER
Keyword(s):  
Virus Infection ◽  
Inhibitory Effect ◽  
Leukaemia Virus ◽  
Murine Sarcoma

Synthesis and structural analysis of curdlan sulfate with a potent inhibitory effect in vitro of AIDS virus infection

1990 ◽  
Vol 23 (16) ◽  
pp. 3717-3722 ◽  
Author(s):  
Takashi Yoshida ◽  
Kenichi Hatanaka ◽  
Toshiyuki Uryu ◽  
Yutaro Kaneko ◽  
Eiichiro Suzuki ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Virus Infection ◽  
Inhibitory Effect ◽  
Aids Virus ◽  
Potent Inhibitory Effect

In vitro inhibition of feline leukaemia virus infection by synthetic peptides derived from the transmembrane domain

2011 ◽  
Vol 16 (6) ◽  
pp. 905-913 ◽  
Author(s):  
Eva Boenzli ◽  
Céline Robert-Tissot ◽  
Giuseppina Sabatino ◽  
Valentino Cattori ◽  
Marina Luisa Meli ◽  
...  
Keyword(s):  
Virus Infection ◽  
Synthetic Peptides ◽  
Transmembrane Domain ◽  
Leukaemia Virus ◽  
Feline Leukaemia Virus ◽  
In Vitro Inhibition

Synthesis and in vitro Inhibitory Effect of L-Glycosyl-Branched Curdlan Sulfates on AIDS Virus Infection

1994 ◽  
Vol 27 (22) ◽  
pp. 6272-6276 ◽  
Author(s):  
Takashi Yoshida ◽  
Yuichi Yasuda ◽  
Toshiyuki Uryu ◽  
Hideki Nakashima ◽  
Naoki Yamamoto ◽  
...  
Keyword(s):  
Virus Infection ◽  
Inhibitory Effect ◽  
Aids Virus

scholarly journals Poly(I)-Poly(C12U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection

2006 ◽  
Vol 50 (5) ◽  
pp. 1768-1772 ◽  
Author(s):  
M. C. Georges-Courbot ◽  
H. Contamin ◽  
C. Faure ◽  
P. Loth ◽  
S. Baize ◽  
...  
Keyword(s):  
Body Weight ◽  
Virus Infection ◽  
Antiviral Activity ◽  
Lethal Dose ◽  
Nipah Virus ◽  
Interferon Inducer ◽  
Hamster Model ◽  
Decarboxylase Inhibitors ◽  
Strong Antiviral Activity

ABSTRACT Clinical nonrandomized trials demonstrate some efficacy for ribavirin in the treatment of patients with severe Nipah virus-induced encephalitis. We report here that EICAR, the 5-ethynyl analogue of ribavirin, and the OMP-decarboxylase inhibitors 6-aza-uridine and pyrazofurin have strong antiviral activity against Nipah virus replication in vitro. Ribavirin and 6-aza-uridine were tested further in hamsters infected with a lethal dose of Nipah virus. The activity of these small-molecule inhibitors was compared with that of the interferon inducer poly(I)-poly(C12U). Both ribavirin and 6-aza-uridine were able to delay but not prevent Nipah virus-induced mortality. Poly(I)-poly(C12U), at 3 mg/kg of body weight daily from the day of infection to 10 days postinfection, prevented mortality in 5 of 6 infected animals.

Effect of Dipyridamole on Spontaneous Platelet Aggregation in Whole Blood Decreases with the Time After Venepuncture: Evidence for the Role of ADP

1987 ◽  
Vol 58 (02) ◽  
pp. 744-748 ◽  
Author(s):  
A R Saniabadi ◽  
G D O Lowe ◽  
J C Barbenel ◽  
C D Forbes
Keyword(s):  
Platelet Aggregation ◽  
Correlation Coefficient ◽  
Whole Blood ◽  
Blood Platelet ◽  
Inhibitory Effect ◽  
Time Interval ◽  
Adp Receptor ◽  
Spontaneous Platelet Aggregation

SummarySpontaneous platelet aggregation (SPA) was studied in human whole blood at 3, 5, 10, 20, 30, 40 and 60 minutes after venepuncture. Using a whole blood platelet counter, SPA was quantified by measuring the fall in single platelet count upon rollermixing aliquots of citrated blood at 37° C. The extent of SPA increased with the time after venepuncture, with a correlation coefficient of 0.819. The inhibitory effect of dipyridamole (Dipy) on SPA was studied: (a) 10 μM at each time interval; (b) 0.5-100 μM at 3 and 30 minutes and (c) 15 μM in combination with 100 μM adenosine, 8 μM 2-chloroadenosine (2ClAd, an ADP receptor blocker) and 50 μM aspirin. There was a rapid decrease in the inhibitory effect of Dipy with the time after venepuncture; the correlation coefficient was -0.533. At all the concentrations studied, Dipy was more effective at 3 minutes than at 30 minutes after venepuncture. A combination of Dipy with adenosine, 2ClAd or aspirin was a more effective inhibitor of SPA than either drug alone. However, when 15 μM Dipy and 10 μM Ad were added together, the inhibitory effect of Dipy was not increased significantly, suggesting that Dipy inhibits platelet aggregation independent of Ad. The increase in SPA with the time after venepuncture was abolished when blood was taken directly into the anticoagulant containing 5 μM 2ClAd. It is suggested that ADP released from the red blood cells is responsible for the increased platelet aggregability with the time after venepuncture and makes a serious contribution to the artifacts of in vitro platelet function studies.

In Vitro Effects of Ethanol on Rabbit Platelet Aggregation, Secretion of Granule Contents, and Cyclic AMP Levels in the Presence of Prostacyclin

1989 ◽  
Vol 61 (02) ◽  
pp. 254-258 ◽  
Author(s):  
Margaret L Rand ◽  
Peter L Gross ◽  
Donna M Jakowec ◽  
Marian A Packham ◽  
J Fraser Mustard
Keyword(s):  
Cyclic Amp ◽  
Inhibitory Effect ◽  
Rabbit Platelet ◽  
Inhibitory Effects ◽  
Low Concentrations ◽  
Rabbit Platelets ◽  
High Concentrations ◽  
In Vitro Effects ◽  
Aggregation Of Platelets

SummaryEthanol, at physiologically tolerable concentrations, inhibits platelet responses to low concentrations of collagen or thrombin, but does not inhibit responses of washed rabbit platelets stimulated with high concentrations of ADP, collagen, or thrombin. However, when platelet responses to high concentrations of collagen or thrombin had been partially inhibited by prostacyclin (PGI2), ethanol had additional inhibitory effects on aggregation and secretion. These effects were also observed with aspirin- treated platelets stimulated with thrombin. Ethanol had no further inhibitory effect on aggregation of platelets stimulated with ADP, or the combination of ADP and epinephrine. Thus, the inhibitory effects of ethanol on platelet responses in the presence of PGI2 were very similar to its inhibitory effects in the absence of PGI2, when platelets were stimulated with lower concentrations of collagen or thrombin. Ethanol did not appear to exert its inhibitory effects by increasing cyclic AMP above basal levels and the additional inhibitory effects of ethanol in the presence of PGI2 did not appear to be brought about by further increases in platelet cyclic AMP levels.

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