Lymphoid Inhibitor of Human Lymphocyte DNA Synthesis and Mitosis in vitro

Nature ◽  
1969 ◽  
Vol 224 (5225) ◽  
pp. 1207-1208 ◽  
Author(s):  
J. F. MOORHEAD ◽  
E. PARASKOVA-TCHERNOZENSKA ◽  
A. J. PIRRIE ◽  
C. HAYES
Keyword(s):  
Dna Synthesis ◽  
Human Lymphocyte ◽  
Lymphocyte Dna Synthesis

Damage by Dichlorvos of Human Lymphocyte DNA

1980 ◽  
Vol 66 (4) ◽  
pp. 425-430 ◽  
Author(s):  
Paolo Perocco ◽  
Angela Fini
Keyword(s):  
Dna Synthesis ◽  
Human Lymphocyte ◽  
Tritiated Thymidine ◽  
Human Lymphocytes ◽  
Ultraviolet Rays ◽  
Thymidine Uptake ◽  
Short Term ◽  
In Vitro System ◽  
Tritiated Thymidine Uptake

The action of dichlorvos (2.2-dichlorovinyldimethyl phosphate) was studied with a short-term in vitro system which utilizes human lymphocytes. The parameters studied were the action exerted by the pesticide on scheduled (semiconservative) and unscheduled (reparative) DNA synthesis measured as tritiated thymidine uptake. The results obtained show that dichlorvos affects semiconservative DNA synthesis, damages human lymphocyte DNA inducing low reparative synthesis, and interferes with DNA repair processes after damage exerted by ultraviolet rays.

scholarly journals Suppression of in vitro lymphocyte DNA synthesis by killed Pseudomonas aeruginosa.

1983 ◽  
Vol 39 (2) ◽  
pp. 630-637 ◽  
Author(s):  
H R Rubin ◽  
R U Sorensen ◽  
P A Chase ◽  
J D Klinger
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Dna Synthesis ◽  
Lymphocyte Dna Synthesis

149 In vivo effects of the beta agonist terbutaline, on rat lymphocyte dna synthesis in vitro

1983 ◽  
Vol 71 (1) ◽  
pp. 126
Author(s):  
C SERIO ◽  
R FREDERICK ◽  
L MANSFIELD ◽  
L PENNEY ◽  
G LECHUGA
Keyword(s):  
Dna Synthesis ◽  
Beta Agonist ◽  
Lymphocyte Dna Synthesis ◽  
In Vivo Effects

Trimethylmethoxyphenyl-Retinoic Acid (Ro 10-1670) and Lymphocyte DNA Synthesis Activity in vitro

Dermatology ◽  
1984 ◽  
Vol 169 (1) ◽  
pp. 18-22
Author(s):  
A.L. Claudy ◽  
O. de Bouteiller ◽  
J.L. Touraine
Keyword(s):  
Retinoic Acid ◽  
Dna Synthesis ◽  
Synthesis Activity ◽  
Lymphocyte Dna Synthesis

scholarly journals Abnormal Nucleic Acid Metabolism of Lymphocytes in Plasma Cell Myeloma and Macroglobulinemia

Blood ◽  
1969 ◽  
Vol 33 (2) ◽  
pp. 300-312 ◽  
Author(s):  
SYDNEY E. SALMON ◽  
H. HUGH FUDENBERG
Keyword(s):  
Nucleic Acid ◽  
Dna Synthesis ◽  
Past History ◽  
Acid Synthesis ◽  
Nucleic Acid Metabolism ◽  
Lymphocyte Function ◽  
Dna And Rna ◽  
Lymphocyte Dna Synthesis

Abstract Twenty-six patients with multiple myeloma and macroglobulinemia of Waldenström were studied clinically and immunologically with characterization of their paraproteins and normal immunoglobulins, as well as by in vitro culture of their peripheral lymphocytes for evaluation of DNA and RNA synthesis after phytohemagglutinin stimulation. The lymphocytes of the patients were found to be significantly deficient in response to PHA as compared to normals and patients with benign hypergammaglobulinemia. Levels of normal immunoglobulins were reduced in almost all of the paraproteinemic patients, but there was not a direct correlation between lymphocyte unresponsiveness and immunoglobulin deficiency. The defect in lymphocyte function appeared to be cellular inasmuch as normal lymphocytes had normal DNA synthesis when cultured in myeloma plasma. The decrease in lymphocyte nucleic acid synthesis appeared to be unrelated to immunoglobulin class, quantitative levels or antigenic characteristics of the patients’ paraproteins. Untreated myeloma patients with a past history of infection had lower levels of lymphocyte DNA synthesis than those patients who lacked such a history, suggesting a relationship between the in vitro lymphocyte response to PHA and the in vivo response to the antigenic challenge of bacterial infection.

Enhancive and suppressive effects of cytomegalovirus on human lymphocyte responses in vitro.

1986 ◽  
Vol 58 (3) ◽  
pp. 909-913 ◽  
Author(s):  
B Wahren ◽  
P Ljungman ◽  
T Paulin ◽  
O Ringdén
Keyword(s):  
Human Lymphocyte ◽  
Lymphocyte Responses

Complement (C5b-9) induces DNA synthesis in rat mesangial cells in vitro

2001 ◽  
Vol 59 (3) ◽  
pp. 905-912
Author(s):  
William G. Couser ◽  
Jeffrey W. Pippin ◽  
Stuart J. Shankland
Keyword(s):  
Dna Synthesis ◽  
Mesangial Cells
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